Eosinophils promote effector functions of lung group 2 innate lymphoid cells in allergic airway inflammation in mice

Allergic asthma is a chronic disease generally characterized by increased production of type 2 cytokines (eg, IL-4, IL-5, and IL-13) and accumulation of lymphocytes and eosinophils into the airway.1 Group 2 innate lymphoid cells (ILC2s) have been identified as critical upstream mediators of type 2 inflammation and the induced airway eosinophilia in translational models of allergic asthma.2-4 In humans, their numbers and activation state are increased in subgroups of people with asthma5-8 and chronic rhinosinusitis with nasal polyps.

Source: Journal of Allergy and Clinical Immunology - April 5, 2023 Category: Allergy & Immunology Authors: William E. LeSuer, Melanie Kienzl, Sergei I. Ochkur, Rudolf Schicho, Alfred D. Doyle, Benjamin L. Wright, Matthew A. Rank, Alexander S. Krupnick, Hirohito Kita, Elizabeth A. Jacobsen Source Type: research