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Condition: Polyps
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Nasal polyp antibody secreting cells have features of long-lived plasma cells and frequently produce autoantibodies and IgE
Nasal polyps (NP) in Chronic rhinosinusitis with NP (CRSwNP) have an increased number of antibody secreting cells (ASCs) that produce autoantibodies against DNA and other self-antigens. Elevated tissue anti-dsDNA IgG levels are prospectively associated with recurrent NP after ESS, but the molecular characteristics of the source ASCs are unknown.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Junqin Bai Source Type: research
Il-4 receptor alpha chain q576r rr genotype is associated with increased markers of type 2 inflammation in aspirin exacerbated respiratory disease
In the US, chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by elevated levels of IL-4 and IL-13. Several single nucleotide polymorphisms within the gene encoding for the shared IL-4 receptor alpha chain have been identified, including Q576R (c.1727A>G). The frequency of the RR genotype was significantly higher among asthmatics and the variant was associated with more severe lower airway disease. The impact of the RR genotype in CRSwNP is unclear.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Whitney Stevens, James Norton, Kris Erickson, Atsushi Kato, Lydia Suh, Roderick Carter, Julia Huang, Anju Peters, Leslie Grammer, David Conley, Stephanie Shintani Smith, Bruce Tan, Kevin Welch, Robert Kern, Carole Ober, Robert Schleimer Source Type: research
Interleukin 4 directly activates olfactory neurons and induces loss of smell in mice
Anosmia is common in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Dupilumab, a human IL-4R α monoclonal antibody that blocks both IL-4 and IL-13 signaling, provides rapid and sustained improvements in sense of smell in patients with CRSwNP via mechanisms not clearly understood. Therefore, we investigated the effects of IL-4 and IL-13 on the mouse olfactory system in vitro and in vivo.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Yannis Hara, Mithilesh Kumar Jha, Hamid Mattoo, Scott Nash, Asif Khan, Jamie Orengo, Alexandra Hicks Source Type: research
Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) Who Did or Did Not Undergo Functional Endoscopic Sinus Surgery (FESS) in a US Real-World Retrospective Cohort Study
There are limited data regarding the characteristics of patients with CRSwNP who undergo FESS vs those who do not.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Asif Khan, Danielle Isaman, Stella Lee, Anju Peters, Peter Hwang, Sietze Reitsma, Natalia Petruski-Ivleva, Scott Nash, Juby Jacob-Nara Source Type: research
Eosinophil, mast cell and basophil microparticle in nasal lavage fluids as potential biomarkers for type 2 inflammation in chronic rhinosinusitis with nasal polyps
Microparticles (MP) are large extracellular vesicles (0.5-1.0 μm) that are released from activated cells. Eosinophils, mast cells and basophils play roles in type 2 inflammation in nasal mucosa in chronic rhinosinusitis with nasal polyps (CRSwNP).
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Toru Takahashi Source Type: research
Oral Corticosteroid Burden and Healthcare Resource Utilization (HCRU) in Patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) Undergoing Functional Endoscopic Sinonasal Surgery (FESS): A Real-World Retrospective Cohort Study
The impact of FESS in reducing oral corticosteroid (OCS) burden and HCRU for patients with CRSwNP is understudied.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Danielle Isaman, Asif Khan, Stella Lee, Anju Peters, Peter Hwang, Sietze Reitsma, Natalia Petruski-Ivleva, Scott Nash, Juby Jacob-Nara Source Type: research
Change in nasal polyp size as an indicator of treatment response: SYNAPSE trial analysis
In patients with chronic rhinosinusitis with nasal polyps (CRSwNP), it is unclear whether NP size (measured by endoscopic NP score [NPS]) relates to nasal airflow and patient perceptions of disease burden. In this abstract associations between NPS and nasal airflow, and NPS and patient-reported outcomes (PRO) were the primarily assessed.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Amber Luong, Joshua Levy, Ludger Klimek, Richard Harvey, Jared Silver, Steven Smith, Abby Fuller, Robert Chan, Peter Hellings Source Type: research
Increased Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM 5) Production and Its Role in Human Nasal Polyps
A previous study demonstrates that CEACAM5 gene expression is highly upregulated in tissues from chronic rhinosinusitis with nasal polyps (CRSwNP) in microarray analysis. CEACAM5 protein production, localization, and association with other inflammatory markers were investigated in CRS.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Jung Yeon Han, Ahrim Moon, Mark Tabor, Susumu Fukahori, Richard Lockey, Seong Cho Source Type: research
Perioperative Mepolizumab in Aspirin-Exacerbated Respiratory Disease Does Not Prevent Nasal Polyp Regrowth: A Case Series
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a defining feature of aspirin-exacerbated respiratory disease (AERD) and leads to impairment in quality of life. Endoscopic sinus surgery (ESS) is standard-of-care treatment for patients with refractory CRSwNP, but disease often recurs after ESS in those with AERD. We hypothesized that perioperative use of an anti-interleukin-5 antibody, mepolizumab, would prevent CRSwNP recurrence post-ESS.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Andrew Supron, Regan Bergmark, Rachel Roditi, Tanya Laidlaw, Kathleen Buchheit Source Type: research
Effects Of Biologics Treatment In Type 2-High Chronic Rhinosinusitis With Nasal Polyp Patients.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by a type 2 inflammation of nasal and sinus mucosa, frequently with comorbid asthma. Development of immunomodulatory drugs, targeting these inflammatory pathways, advanced treatment methods. We aimed to investigate how different biologicals modulate inflammation and understanding different responder rates in distinct patient populations.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Sharon Van Nevel, Tim Meese, Gabriele Holtappels, Natalie De Ruyck, Stijn Vanhee, Nan Zhang, Filip Van Nieuwerburgh, Claus Bachert Source Type: research
Tezepelumab Efficacy By SNOT-22 Score In Patients With Severe, Uncontrolled Asthma And Comorbid Nasal Polyps In NAVIGATOR
Chronic rhinosinusitis with nasal polyposis (NP), an inflammatory disease of the upper airway, is a common comorbidity of severe asthma. This post hoc analysis evaluated the effect of tezepelumab on Sino –Nasal Outcomes Test (SNOT)-22 score in patients from the phase 3 NAVIGATOR study (NCT03347279) with a history of NP.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Joshua Jacobs, Flavia Hoyte, Joseph Spahn, Chris Ambrose, Nicole Martin, Sylvia Vong, Scott Caveney, Bill Cook, Gene Colice Source Type: research
Real World Benefits of Mepolizumab in Patients With Severe Asthma and Comorbid Chronic Rhinosinusitis With Nasal Polyps (CRSwNP): Post Hoc Analysis of REALITI-A
In clinical trials, mepolizumab reduced clinically significant exacerbations (CSEs) and maintenance oral corticosteroid (mOCS) use in patients with severe eosinophilic asthma (SEA); greater benefits were observed in patients with comorbid CRSwNP. Equivalent long-term real-world data would enhance this evidence.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Frances Lee, Mark Liu, Diego Bagnasco, Andrea Matucci, Charles Pilette, Robert Price, Rafael Alfonso-Cristancho, Rupert Jakes, Peter Howarth Source Type: research
Chronic rhinosinusitis with nasal polyps as a major comorbid disease in severe asthma patients: Evidence from severe asthma registry of Kuwait
The clinical and laboratory features of patients enrolled in the severe asthma registry in Kuwait were evaluated, with special emphasis on chronic rhinosinusitis with nasal polyposis (CRSwNP).
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Mona Al-Ahmad Source Type: research
Asthma outcomes with biologic medications for patients with asthma and concurrent chronic rhinosinusitis
Efficacy of certain biologics for treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) or asthma is well documented, however there has been less research performed for asthma outcomes for patients with both asthma and chronic rhinosinusitis (CRS). We aimed to study improvement in asthma control for patients with concurrent asthma and CRS (asthma+CRS) after initiation of a biologic treatment, and to investigate whether the presence of nasal polyps, demographic factors, or other presence of atopic conditions impacts response to asthma biologics.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Emilio Jauregui, Pete Batra, Bobby Tajudeen, Peter Papagiannopoulos, Mahboobeh Mahdavinia Source Type: research
Usefulness of the JESREC scoring system in assessing asthma patients with eosinophilic chronic rhinosinusitis
In this study, we assessed the usefulness of this system in evaluating asthma patients with ECRS.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Shingo Takahashi, Toshihiro Shirai, Taisuke Akamatsu, Aya Matsubara Source Type: research
