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Total 2492 results found since Jan 2013.
Clinical Use Of Biologics For Asthma Treatment By Allergy Specialists: A Questionnaire Survey.
CONCLUSION: This represents the largest survey of allergy specialists, about real-world use of asthma biologics. It appears there has been reasonably good dissemination and application of current guidelines among allergists based on prescribing patterns. However, there responses demonstrate the need for the continued modification of asthma guidelines that incorporate novel biologics and other pathway-specific agents into step therapy. As clinical phenotypes and predictive biomarkers develop, allergy specialists will be better prepared to practice precision medicine that optimizes use of asthma biologics.
PMID: 3262901...
Source: Annals of Allergy, Asthma and Immunology - July 2, 2020 Category: Allergy & Immunology Authors: Kuruvilla M, Ariue B, Oppenheimer JJ, Singh U, Bernstein JA Tags: Ann Allergy Asthma Immunol Source Type: research
Chronic sinusitis pathophysiology: The role of allergy.
CONCLUSION: Treatments of this disease include agents directed at allergic mediators such as leukotriene modifiers and corticosteroids, although this doesnot necessarily signify that an IgE-dependent mechanism can be ascribed. However, more recently, omalizumab has shown promise, including in patientswithout obvious aeroallergen sensitization. Although many aspects of the role of allergy in CHES remain a mystery, the mechanisms that are being elucidatedallow for improved understanding of this disease, which ultimately will lead to better treatments for our patients who live daily with this disease.
PMID: 23601202 [Pub...
Source: American Journal of Rhinology and Allergy - April 18, 2013 Category: ENT & OMF Authors: Kennedy JL, Borish L Tags: Am J Rhinol Allergy Source Type: research
Chapter 16: Determining the role of allergy in sinonasal disease.
Abstract
The contributing role of specific IgE sensitization in the pathophysiology of sinonasal diseases including rhinitis, chronic rhinosinusitis (CRS), and nasal polyps is explored. Although it is estimated that sensitization to environmental allergens is present in 75% of patients with rhinitis, the role of allergy in CRS and nasal polyps is less certain. However, when atopy is present in the setting of nasal polyps, it is associated with worse quality of life and a higher incidence of asthma. Several theories have been put forth whereby inhalant aeroallergen exposure could drive the inflammatory response tha...
Source: American Journal of Rhinology and Allergy - May 1, 2013 Category: ENT & OMF Authors: Settipane RA, Borish L, Peters AT Tags: Am J Rhinol Allergy Source Type: research
XXIV World Allergy Congress 2015
Table of Contents
A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts
Jae-Min Shin, Heung-Man Lee, Il-Ho Park
A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines
Hyun-Sun Yoon, Gyeong Yul Park
A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome
Margit Zeher
A4 Betamethasone suppresses Th2 cell development induced by langerhans cell like dendr...
Source: World Allergy Organization Journal - April 18, 2016 Category: Allergy & Immunology Source Type: research
The allergy profile and accompanying sinonasal pathologies in patients with bronchial asthma
Conclusion: In bronchial asthma patients with positive test result for skin prick testing, the most common allergy was found against the grains, weeds, and the house dusts. Deviated septum, turbinate hypertrophy, serous discharge, and pallor of the mucous membranes were often detected pathologies in physical examination. According to the radiologic findings, mucosal thickening and opacification of the sinuses were most common imaging findings.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Ozkara, B., Sevketbeyoglu, H., Kose, M., Tas, D., Salihlioglu, M. Tags: 5.3 Allergy and Immunology Source Type: research
Central compartment involvement in aspirin ‐exacerbated respiratory disease: the role of allergy and previous sinus surgery
ConclusionMost AERD patients exhibit AR, and this correlates with CC disease. As the number of surgeries increases, MT resection may predispose to polyposis of the septum.
Source: International Forum of Allergy and Rhinology - June 26, 2019 Category: Allergy & Immunology Authors: John M. DelGaudio,
Joshua M. Levy,
Sarah K. Wise Tags: ORIGINAL ARTICLE Source Type: research
Clinical Management and Use of Health Care Resources in the Treatment of Nasal Polyposis in Spanish Allergy Centers: The POLAR Study.
CONCLUSIONS: NP is a chronic inflammatory disease that generates considerable use of health care resources. The close association with atopy, asthma, and NSAID hypersensitivity highlights the usefulness of an allergy workup in all patients with NP. Analysis of the clinical management of NP by allergists in Spain revealed a high degree of compliance with EPOS diagnostic and therapeutic recommendations.
PMID: 26310042 [PubMed - in process]
Source: Journal of Investigational Allergology and Clinical Immunology - August 30, 2015 Category: Allergy & Immunology Authors: Rondón C, Dávila I, Navarro Pulido AM, Sánchez MC, Montoro J, Matheu V, Lluch-Bernal M, Fernández-Parra B, Ibáñez MD, Dordal MT, Colás C, Antón E, Valero A, Rhinoconjunctivitis Committee, Spanish Society of Allergy and Clinical Immunology Tags: J Investig Allergol Clin Immunol Source Type: research
Central compartment atopic disease: prevalence of allergy and asthma compared with other subtypes of chronic rhinosinusitis with nasal polyps
ConclusionCCAD represents a clinically distinct phenotype of CRSwNP with a high prevalence of allergy and low prevalence of asthma. Patients with both CCAD and diffuse sinonasal polyps had an allergy prevalence approaching that of CCAD and an asthma prevalence approaching CRSwNP NOS.
Source: International Forum of Allergy and Rhinology - October 9, 2019 Category: Allergy & Immunology Authors: Sonya Marcus,
Joseph Schertzer,
Lauren T. Roland,
Sarah K. Wise,
Joshua M. Levy,
John M. DelGaudio Tags: ORIGINAL ARTICLE Source Type: research
Accumulation of effector memory CD8(+) T cells in nasal polyps.
CONCLUSION: Sinus mucosa in CRS with NPs is characterized by a significant enrichment of CD8(+) T cells and a relative deficiency of CD4(+) T cells. The majority of NP CD8(+) T cells had a terminally differentiated, mature, effector memory phenotype, which raises the question, whether these cells are pathogenic or appear as a consequence of inflammation, independent of the presence of allergy or positive microbial culture.
PMID: 24119592 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - September 1, 2013 Category: ENT & OMF Authors: Pant H, Hughes A, Miljkovic D, Schembri M, Wormald P, Macardle P, Grose R, Zola H, Krumbiegel D Tags: Am J Rhinol Allergy Source Type: research
CD4(+) and CD8(+) regulatory T cells in chronic rhinosinusitis mucosa.
CONCLUSION: A higher percentage of CD4Treg and activated T-helper cells in CRS mucosa suggests increased inflammation in CRS, independent of the presence of allergy, microbial culture results, or eosinophilic mucus. However, the decreased ratio of CD4Treg versus activated T-helper cells in CRS and reduced CD8Treg population in CRSwNPs indicates an inflammatory bias and the inability to control mucosal disease.
PMID: 24717938 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - March 1, 2014 Category: ENT & OMF Authors: Pant H, Hughes A, Schembri M, Miljkovic D, Krumbiegel D Tags: Am J Rhinol Allergy Source Type: research
Surgical treatment of nasal polyposis: A comparison between cutting forceps and microdebrider.
CONCLUSION: The manual instrument allowed for a significantly lower recurrence incidence but yielded a higher rate of synechia formation compared with the microdebrider. Only asthma was significantly associated with a poorer clinical outcome, and gender, age, allergy, and eosinophilia did not affect the surgical prognosis.
PMID: 24274215 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - November 1, 2013 Category: ENT & OMF Authors: Tirelli G, Gatto A, Spinato G, Tofanelli M Tags: Am J Rhinol Allergy Source Type: research
Elevated total serum IgE in nonatopic patients with aspirin-exacerbated respiratory disease.
CONCLUSION: In a subset of patients with AERD, we observed elevated total serum IgE even when atopy was not present. To better understand the disease, the cause and clinical relevance of this phenomenon deserves further exploration.
PMID: 25197914 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - July 1, 2014 Category: ENT & OMF Authors: Johns CB, Laidlaw TM Tags: Am J Rhinol Allergy Source Type: research
Blood eosinophil-to-basophil ratio in patients with sinonasal polyps: Does it have a clinical role?
CONCLUSION: This study confirms the increasingly interesting role emerging for blood eosinophils and basophils in different CRSwNP endotypes. The bEBR seems to be a parameter worth investigating in different CRSwNP endotypes, because it is significantly higher in patients with allergy, asthma, and aspirin-exacerbated respiratory disease.
PMID: 28743424 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - July 22, 2017 Category: Allergy & Immunology Authors: Brescia G, Barion U, Zanotti C, Cinetto F, Giacomelli L, Martini A, Marioni G Tags: Ann Allergy Asthma Immunol Source Type: research
Impact of Allergy and Eosinophils on the Morbidity of Chronic Rhinosinusitis with Nasal Polyps in Northwest China
Conclusion: EOS is a significant factor related to the morbidity of CRSwNP in Northwest China. Elevated EOS levels occurring in the context of nonallergic rhinitis constitute a risk factor for CRSwNP. Similarly, elevated EOS levels occurring in the context of allergen-negative rhinitis are also an important risk factor for morbidity of CRSwNP.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research
A real-world assessment of asthma with chronic rhinosinusitis.
CONCLUSION: The present study confirmed that CRS is frequent asthma comorbidity as concerns more than one-third of asthmatic outpatients. CRSwNP is associated with type 2 inflammation and blood eosinophilia. These outcomes underline that CRSwNPasthma phenotype deserves adequate attention for careful management and optimal identification of the best-tailored therapy.
PMID: 32171930 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - March 10, 2020 Category: Allergy & Immunology Authors: Massimo Ricciardolo FL, Levra S, Sprio AE, Bertolini F, Carriero V, Gallo F, Ciprandi G Tags: Ann Allergy Asthma Immunol Source Type: research
