Accumulation of effector memory CD8(+) T cells in nasal polyps.

CONCLUSION: Sinus mucosa in CRS with NPs is characterized by a significant enrichment of CD8(+) T cells and a relative deficiency of CD4(+) T cells. The majority of NP CD8(+) T cells had a terminally differentiated, mature, effector memory phenotype, which raises the question, whether these cells are pathogenic or appear as a consequence of inflammation, independent of the presence of allergy or positive microbial culture.
PMID: 24119592 [PubMed - as supplied by publisher]

Source: American Journal of Rhinology and Allergy - September 1, 2013 Category: ENT & OMF Authors: Pant H, Hughes A, Miljkovic D, Schembri M, Wormald P, Macardle P, Grose R, Zola H, Krumbiegel D Tags: Am J Rhinol Allergy Source Type: research