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Condition: Polyps
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Total 2492 results found since Jan 2013.
New Developments in Allergic Fungal Rhinosinusitis Pathophysiology and Treatment
CONCLUSION: AFRS is an endotype of CRS with nasal polyps (CRSwNP) for which the molecular pathways leading to its inflammatory dysfunction are beginning to be illuminated. In addition to affecting treatment options, these understandings may shape necessary changes to diagnostic criteria and the extrapolated effects of environmental changes on AFRS. More critically, a better appreciation of fungi-driven inflammatory pathways may have implications for the understanding of broader CRS inflammation.PMID:36848273 | DOI:10.1177/19458924231152983
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: Brian H Cameron Amber U Luong Source Type: research
Scientific Advancements That Empower Us to Understand CRS Pathophysiology
CONCLUSION: These emerging scientific technologies represent outstanding opportunities to identify and develop more targeted therapeutics for different pathways that lead to CRSwNP. An additional understanding of these mechanisms will be critical for developing future therapies for CRSwNP.PMID:36848272 | DOI:10.1177/19458924221148026
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: Hannan A Qureshi Zechariah G Franks Asiana Gurung Murugappan Ramanathan Source Type: research
Advances in Sinus Surgery for Nasal Polyps
CONCLUSION: Surgical intervention remains a mainstay of therapy for CRSwNP. Newer techniques revolve around improving access for topical steroid therapy.PMID:36848271 | DOI:10.1177/19458924221147783
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: T Graham Norwood Jessica W Grayson Bradford A Woodworth Source Type: research
Endotyping Chronic Rhinosinusitis with Nasal Polyps: Understanding Inflammation Beyond Phenotypes
Am J Rhinol Allergy. 2023 Mar;37(2):132-139. doi: 10.1177/19458924221149003.ABSTRACTChronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogenous group of inflammatory conditions impacting the nose and paranasal sinuses. Our understanding of the underlying pathobiology of CRSwNP has substantially improved due to ongoing translational research efforts. Advances in treatment options, including targeted respiratory biologic therapy for CRSwNP, allow for more personalized approaches for CRSwNP patient care. Patients with CRSwNP are typically classified to one or more endotype based on the presence of type 1, type 2, and ...
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: Chongjia C Chen Kathleen M Buchheit Source Type: research
B Lineage Cells and IgE in Allergic Rhinitis and CRSwNP and the Role of Omalizumab Treatment
CONCLUSION: This review highlights current knowledge of the roles of B cells and IgE in the pathogenesis of AR and CRSwNP and a small comparison between the 2 diseases. More systemic studies should be done to elevate the understanding of these diseases and their treatment.PMID:36848269 | DOI:10.1177/19458924221147770
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: Junqin Bai Bruce K Tan Source Type: research
Update on Allergic Fungal Rhinosinusitis
Allergic fungal rhinosinusitis (AFRS) is a unique clinical entity that falls under the broader umbrella of chronic rhinosinusitis with nasal polyps (CRSwNP) with type 2 inflammation. It is characterized by nasal polyposis, production of characteristic thick eosinophilic mucin, and expansile change of involved sinus cavities.The diagnosis is classically made using the Bent and Kuhn criteria. However, recent studies have demonstrated lack of specificity of some major criteria. The need to fulfil all five criteria before diagnosing AFRS mitigates this partially, but renders the criteria cumbersome to use, and highlights the n...
Source: Annals of Allergy, Asthma and Immunology - February 25, 2023 Category: Allergy & Immunology Authors: Andy J. Chua, Ali Jafar, Amber U. Luong Tags: CME Reviews Source Type: research
Characteristics of chronic rhinosinusitis phenotypes in patients undergoing functional endoscopic sinus surgery: an observational cohort retrospective study
This study analyzed the characteristics of chronic rhinosinusitis patients with and without nasal polyps failing conservative treatment and undergoing functional endoscopic sinus surgery as part of their treatment for chronic inflammatory sinonasal disease. The aim of this retrospective single-institution cohort study conducted at a university hospital tertiary referral center was to evaluate the characteristics of patients with both disease phenotypes in whom conservative treatment was unsuccessful. Patients who were surgically treated with functional endoscopic sinus surgery performed by two rhinology surgeons during a o...
Source: Acta Clinica Croatica - February 23, 2023 Category: General Medicine Authors: Martina Radeti ć Jeffry Mattar Andro Ko šec Filip Bacan Tomislav Baudoin Source Type: research
MiR-214 Expression Is Elevated in Chronic Rhinosinusitis Mucosa and Regulates Lipopolysaccharide-Mediated Responses in Undifferentiated Human Nasal Epithelial Cell Culture
CONCLUSION: Taken together, miR-214 regulates LPS-mediated inflammation and MUC5AC expression via targeting SIRT1, and STAT3/GDF15 may involve in the regulation of miR-214 inhibitor on inflammation and MUC5AC expression.PMID:36797977 | DOI:10.1177/19458924231152683
Source: American Journal of Rhinology and Allergy - February 17, 2023 Category: ENT & OMF Authors: Zhou Wang Dong Lin Yuxiang Zhao Hui Liu Ting Yang An Li Source Type: research
