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Condition: Polyps
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Predictive Significance of Claudin-3 for Epithelial Barrier Dysfunction in Chronic Rhinosinusitis With Nasal Polyps
CONCLUSION: In this study, we suggest that claudin-3 could be a valuable biomarker for predicting nasal epithelial barrier defects and disease severity in CRSwNP.PMID:37153980
Source: Allergy, Asthma and Immunology Research - May 8, 2023 Category: Allergy & Immunology Authors: Zhi-Qun Huang Jing Ye Jing Liu Li-Ying Sun Hsiao Hui Ong Yong-Hao Wei Shu-Cai Fu Xiao-Xun Hu Yu Xu De-Yun Wang Source Type: research
IL-21 induces pyroptosis of Treg cells via Akt –mTOR–NLRP3–caspase 1 axis in eosinophilic chronic rhinosinusitis
Regulatory T (Treg) cells, which prevent inflammation-induced eosinophil infiltration, are deficient in nasal polyps (NPs) in patients with eosinophilic chronic rhinosinusitis (ECRS). It is concomitant with loss of Foxp3 after certain inflammatory stimuli.
Source: Journal of Allergy and Clinical Immunology - May 8, 2023 Category: Allergy & Immunology Authors: Lihong Chang, Haotian Wu, Weiqiang Huang, Yue Li, Ye Chen, Xia Li, Zhouzhou Yao, Xiaohong Chen, Xiaoping Lai, Rui Zheng, Zizhen Huang, Xifu Wu, Gehua Zhang Source Type: research
Reply
We thank Pjevac et al1 for their interest in our article “Alterations of nasal microbiome in eosinophilic chronic rhinosinusitis.”2 From the clinician's perspective, the eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) endotype is frequently associated with poorer treatment effectiveness and highe r polyp recurrence rates. Identifying specific risk factors for polyp recurrence may provide valuable guidance for treatment selection and appropriate management of nasal polyps. Therefore, the cutoff value of mucosal eosinophils, which can accurately identify polyp recurrence, is of more interest t o clinicians.
Source: Journal of Allergy and Clinical Immunology - May 5, 2023 Category: Allergy & Immunology Authors: Yibo Liang, Chenting Zhang, Runxiang Xie, Guimin Zhang Tags: Correspondence Source Type: research
Pitfalls in sampling and analyzing low-biomass human nasal microbiome samples
We read with great interest the original article by Liang et al on alterations of the microbiome in eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP).1 Unlike the authors of previous reports who did not observe any changes or reduced α-diversity in patients with CRS versus in healthy controls, Liang et al1 report a higher α-diversity in pat ients with eCRSwNP and suggest using the nasal microbiome as a novel diagnostic classifier for eCRSwNP. Despite these interesting findings, we would like to raise some concerns.
Source: Journal of Allergy and Clinical Immunology - May 5, 2023 Category: Allergy & Immunology Authors: Petra Pjevac, Tina Bartosik, Sven Schneider, Julia Eckl-Dorna Tags: Correspondence Source Type: research
Consensus on the management of united airways disease with type 2 inflammation: a multidisciplinary Delphi study
Scientific evidence on patients with multimorbid type 2 asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) from a united airways disease (UAD) perspective remains scarce, despite the frequent coexist...
Source: Allergy, Asthma and Clinical Immunology - April 23, 2023 Category: Allergy & Immunology Authors: Marina Blanco-Aparicio, Javier Dom ínguez-Ortega, Carolina Cisneros, Carlos Colás, Francisco Casas, Alfonso del Cuvillo, Isam Alobid, Santiago Quirce and Joaquim Mullol Tags: Research Source Type: research
Inflammatory Endotypes of Chronic Rhinosinusitis in the Korean Population: Distinct Expression of Type 3 Inflammation
CONCLUSIONS: In Koreans, there is a distinct T3 CRS endotype showing a high proportion of CRSwNP and severe disease extent, along with T2 CRS.PMID:37075796
Source: Allergy, Asthma and Immunology Research - April 19, 2023 Category: Allergy & Immunology Authors: Jin-Young Min Jin Youp Kim Chung Man Sung Seon Tae Kim Hyun-Jin Cho Sue Jean Mun Sung-Woo Cho Sang Duk Hong Gwanghui Ryu Kyoung Rai Cho Young Hyo Kim Soo Kyoung Park Dong-Kyu Kim Dong Hoon Lee Sung Jae Heo Ki-Il Lee Su Jin Kim Sangjun Lee Ji-Hun Mo Seung- Source Type: research
