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Condition: Polyps
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Total 2492 results found since Jan 2013.
Current Understanding of the Role of Eosinophils in CRSwNP and Implications for Treatment with Mepolizumab and Benralizumab
CONCLUSION: Blockade of IL5/IL5R alone would appear to provide limited "real life" clinical benefit in patients with CRSwNP due to the complexities of the pathophysiology of the condition. Therapy aimed at several simultaneous cytokine targets has logic but well-designed trials are unlikely to be forthcoming in the short term due to the financial cost and commercial conflicts of interest.PMID:36848284 | DOI:10.1177/19458924221149270
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: A Simon Carney Peter K Smith Source Type: research
State of the Art Medical Management of Nasal Polyps
CONCLUSIONS: Topical steroid therapy is clearly effective for CRSwNP, and recent studies demonstrate the safety and efficacy of high-dose nasal steroid rinses. Alternate delivery methods for local steroids may be useful for patients who are not responding to or who are noncompliant with conventional intranasal corticosteroid sprays and rinses. Future studies are needed to clarify if oral or topical antibiotics, oral anti-leukotrienes, or other novel therapies are significantly effective in decreasing symptoms and improving the quality of life in patients with CRSwNP.PMID:36848283 | DOI:10.1177/19458924221145256
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: Kelly L Staricha Hawa M Ali Janalee K Stokken Source Type: research
Core Outcome Measures in Chronic Rhinosinusitis With Nasal Polyps: In Practice and Research
Am J Rhinol Allergy. 2023 Mar;37(2):232-239. doi: 10.1177/19458924231154070.ABSTRACTHeterogeneity in outcomes used in clinical trials prevents meta-analysis and contributes to research waste. Core outcome sets aim to address this by defining a small number of essential outcomes that should be measured in all effectiveness trials. Adoption in routine clinical practice can further improve outcomes for patients.There has been a rapid growth in therapeutic options available for patients with chronic rhinosinusitis with nasal polyps, but difficulty comparing results leads to uncertainty into optimum management, and there is a n...
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: Alaaeldein Abdulghany Pavol Surda Claire Hopkins Source Type: research
Olfaction Now and in the Future in CRSwNP
CONCLUSION: Olfactory dysfunction is highly prevalent in the CRSwNP population. Although significant advances have been made in our understanding of olfactory dysfunction in the setting of CRS, additional studies are needed to elucidate cellular and molecular changes mediated by type 2-mediated inflammation in the olfactory epithelium with potential downstream effects on the central olfactory system. Further identification of these underlying basic mechanisms will be vital for developing future therapies targeted to improve olfactory dysfunction in patients with CRSwNP.PMID:36848279 | DOI:10.1177/19458924231153485
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: Hannan A Qureshi Andrew P Lane Source Type: research
Understanding the CRSwNP Patient as Whole
CONCLUSION: Recognition and addressing CRSwNP comorbidities such as allergic rhinitis, asthma, sleep disorders, gastroesophageal reflux disease, and cognitive function impairment are important to optimally understand and manage the patient with CRSwNP as a whole.PMID:36848278 | DOI:10.1177/19458924231152671
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: Sindhura Bandi Ellen Stephen Keerthi Bansal Mahboobeh Mahdavinia Source Type: research
Biologics for Nasal Polyps: Synthesizing Current Recommendations into a Practical Clinical Algorithm
CONCLUSIONS: Biologics are emerging as an important option in the management of patients with CRSwNP. While more data is required to fully inform indications, treatment selection, and health economics related to their use, biologics may offer robust symptom relief to patients who have failed other interventions.PMID:36848277 | DOI:10.1177/19458924221147758
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: Neal R Godse Anjeni Keswani Andrew P Lane Stella E Lee Raj Sindwani Source Type: research
The Impact of Social Determinants and Air Pollution on Healthcare Disparities in Chronic Rhinosinusitis With Nasal Polyps
CONCLUSION: Healthcare disparities in the diagnosis and treatment of CRSwNP differentially affect racial minorities and individuals of lower socioeconomic status. Increased air pollution exposure in areas of lower socioeconomic status is a compounding factor. Clinician advocacy for greater healthcare access and reductions in environmental exposures for patients, among other societal changes, may help improve disparities.PMID:36848276 | DOI:10.1177/19458924231153483
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: Rachel Peterson Anjeni Keswani Source Type: research
< em > AJRA < /em > Special Issue on Nasal Polyps
Am J Rhinol Allergy. 2023 Mar;37(2):130-131. doi: 10.1177/19458924231157236.NO ABSTRACTPMID:36848275 | DOI:10.1177/19458924231157236
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: Stella E Lee Anjeni Keswani Andrew P Lane Raj Sindwani Source Type: research
Economics of Medical and Surgical Management of Chronic Rhinosinusitis with Nasal Polyps: A Contemporary Review
CONCLUSION: CRSwNP is a chronic condition with high recurrence rates making it a challenge to manage over time. Current research suggests that FESS is more cost-effective than medical management, including use of newer biologics. Further investigation into both direct and indirect costs associated with medical management is warranted to perform accurate cost-effectiveness analyses and allow for the best allocation of limited healthcare resources.PMID:36848274 | DOI:10.1177/19458924221147501
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: Nikita Chapurin Sofia Khan Jorge Gutierrez Zachary M Soler Source Type: research
New Developments in Allergic Fungal Rhinosinusitis Pathophysiology and Treatment
CONCLUSION: AFRS is an endotype of CRS with nasal polyps (CRSwNP) for which the molecular pathways leading to its inflammatory dysfunction are beginning to be illuminated. In addition to affecting treatment options, these understandings may shape necessary changes to diagnostic criteria and the extrapolated effects of environmental changes on AFRS. More critically, a better appreciation of fungi-driven inflammatory pathways may have implications for the understanding of broader CRS inflammation.PMID:36848273 | DOI:10.1177/19458924231152983
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: Brian H Cameron Amber U Luong Source Type: research
Scientific Advancements That Empower Us to Understand CRS Pathophysiology
CONCLUSION: These emerging scientific technologies represent outstanding opportunities to identify and develop more targeted therapeutics for different pathways that lead to CRSwNP. An additional understanding of these mechanisms will be critical for developing future therapies for CRSwNP.PMID:36848272 | DOI:10.1177/19458924221148026
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: Hannan A Qureshi Zechariah G Franks Asiana Gurung Murugappan Ramanathan Source Type: research
Advances in Sinus Surgery for Nasal Polyps
CONCLUSION: Surgical intervention remains a mainstay of therapy for CRSwNP. Newer techniques revolve around improving access for topical steroid therapy.PMID:36848271 | DOI:10.1177/19458924221147783
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: T Graham Norwood Jessica W Grayson Bradford A Woodworth Source Type: research
Endotyping Chronic Rhinosinusitis with Nasal Polyps: Understanding Inflammation Beyond Phenotypes
Am J Rhinol Allergy. 2023 Mar;37(2):132-139. doi: 10.1177/19458924221149003.ABSTRACTChronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogenous group of inflammatory conditions impacting the nose and paranasal sinuses. Our understanding of the underlying pathobiology of CRSwNP has substantially improved due to ongoing translational research efforts. Advances in treatment options, including targeted respiratory biologic therapy for CRSwNP, allow for more personalized approaches for CRSwNP patient care. Patients with CRSwNP are typically classified to one or more endotype based on the presence of type 1, type 2, and ...
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: Chongjia C Chen Kathleen M Buchheit Source Type: research
B Lineage Cells and IgE in Allergic Rhinitis and CRSwNP and the Role of Omalizumab Treatment
CONCLUSION: This review highlights current knowledge of the roles of B cells and IgE in the pathogenesis of AR and CRSwNP and a small comparison between the 2 diseases. More systemic studies should be done to elevate the understanding of these diseases and their treatment.PMID:36848269 | DOI:10.1177/19458924221147770
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: Junqin Bai Bruce K Tan Source Type: research
