Pheno-Endotyping Antrochoanal Nasal Polyposis

This article reviews the current knowledge of the etiology, inflammatory parameters, and microscopic findings of ACP.Recent FindingsThe inflammatory pattern of ACP appears to center around a neutrophilic inflammation T1-dominant endotype. Apart from the inflammatory component of ACP, at the microscopic level, the presence of tissue remodeling, mostly fibrin deposition and edema, and cysts in the epithelium and lamina propria has been described. Although the origin of this T1-dominant endotype immune response of ACPs is not entirely clear, it could be related to a lymphatic obstruction mechanism.SummaryThis review serves to define a phenotype of ACP with potential endotypes based on the characteristics of the inflammatory parameters, microscopic findings, and hypotheses about the pathogenesis of ACP.
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research