Genetics and epigenetics of chronic rhinosinusitis

Discerning the genetics and epigenetics of chronic rhinosinusitis (CRS) may optimize outcomes through early diagnostics, personalized and novel therapeutics, and early prognostication. CRS associated with cystic fibrosis and primary ciliary dyskinesia has well-characterized genetic mutations. Most CRS subjects, however, do not exhibit identifiable monogenic alterations. Clustering in related individuals is seen in CRS with nasal polyps. Spouses of subjects with CRS without nasal polyps also may be at increased risk of the same disease.

https://www.jacionline.org/article/S0091-6749(23)00035-0/abstract?rss=yes

Source: Journal of Allergy and Clinical Immunology - February 14, 2023 Category: Allergy & Immunology Authors: Devyani Lal, Tripti Brar, Shreya Pusapadi Ramkumar, Jingyun Li, Atsushi Kato, Luo Zhang Tags: Review article Source Type: research