Translational Research : the journal of laboratory and clinical medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis
In conclusion, this study demonstrated that EGR2 played a pathogenic role in renal fibrosis by a p-STAT3-EGR2-p-Smad3 axis. Thus, targeting EGR2 could be a promising strategy for CKD treatment.PMID:38679230 | DOI:10.1016/j.trsl.2024.04.005 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - April 28, 2024 Category: Laboratory Medicine Authors: Anni Song Ruiwei Yan Wei Xiong Huiling Xiang Jing Huang Anni Jiang Chun Zhang Source Type: research

Extra-nuclear tert counteracts oxidative stress and promotes progression in papillary thyroid carcinoma
In conclusion, our data indicate that extra-nuclear TERT is involved in reducing the effect of excessive OS, thus promoting cancer cell survival. Extra-nuclear TERT may thus represent a marker of cancer progression and a possible therapeutic target in PTC.PMID:38670453 | DOI:10.1016/j.trsl.2024.04.004 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - April 26, 2024 Category: Laboratory Medicine Authors: Marina Muzza Gabriele Pogliaghi Carla Colombo Elisa Stellaria Grassi Erika Carbone Sonia Palazzo Francesco Frattini Giacomo Gazzano Luca Persani Laura Fugazzola Source Type: research

Inhibition of Usp14 ameliorates renal ischemia-reperfusion injury by reducing Tfap2a stabilization and facilitating mitophagy
This study aimed to evaluate the impact of ubiquitin-specific peptidase 14 (Usp14), a deubiquitinase, in IR injury by influencing mitophagy. Utilizing a murine model of renal IR injury, Usp14 silencing was found to ameliorate kidney injury, leading to decreased levels of serum creatinine and blood urea nitrogen, alongside diminished oxidative stress and inflammation. In renal epithelial cells subjected to hypoxia/reoxygenation (H/R), Usp14 knockdown increased cell viability and reduced apoptosis. Further mechanistic studies revealed that Usp14 interacted with and deubiquitinated transcription factor AP-2 alpha (Tfap2a), th...
Source: Translational Research : the journal of laboratory and clinical medicine - April 21, 2024 Category: Laboratory Medicine Authors: Yang Li Boqing Dong Ying Wang Huanjing Bi Jing Zhang Chenguang Ding Chenge Wang Xiaoming Ding Wujun Xue Source Type: research

Targeting the Devil: Strategies Against Cancer-Associated Fibroblasts in Colorectal Cancer
In conclusion, the aim of our review is to elucidate the significance and challenges of advancing in-depth research on CAFs, while outlining the pathway to uncover the complex roles of CAFs in CRC and underscore their significant potential as therapeutic targets.PMID:38614213 | DOI:10.1016/j.trsl.2024.04.003 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - April 13, 2024 Category: Laboratory Medicine Authors: Yuting Chen Zhiyong Liang Maode Lai Source Type: research

Retraction notice to "Transfer of microRNA-221 from mesenchymal stem cell-derived extracellular vesicles inhibits atherosclerotic plaque formation" [Transl. Res. 226 (2020) 83-95]
Transl Res. 2024 Apr 11;268:97. doi: 10.1016/j.trsl.2024.03.010. Online ahead of print.NO ABSTRACTPMID:38608437 | DOI:10.1016/j.trsl.2024.03.010 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - April 12, 2024 Category: Laboratory Medicine Authors: Ziyuan Guo Zhuo Zhao Chuang Yang Chunli Song Source Type: research