Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis

In conclusion, this study demonstrated that EGR2 played a pathogenic role in renal fibrosis by a p-STAT3-EGR2-p-Smad3 axis. Thus, targeting EGR2 could be a promising strategy for CKD treatment.PMID:38679230 | DOI:10.1016/j.trsl.2024.04.005

Source: Translational Research : the journal of laboratory and clinical medicine - April 28, 2024 Category: Laboratory Medicine Authors: Anni Song Ruiwei Yan Wei Xiong Huiling Xiang Jing Huang Anni Jiang Chun Zhang Source Type: research