Pre-treatment systemic inflammation response index and systemic immune inflammation in patients with primary central nerve system lymphoma as a useful prognostic indicator
ConclusionSimple, less expensive, and routinely ordered preoperative blood count assessments such as SIRI and SII predict the OS of patients with PCNSL. This study demonstrated that PCNSL is associated with pre-treatment systemic immune-inflammation states. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 25, 2024 Category: Cancer & Oncology Source Type: research
Exploring the impact of primary care utilization and health information exchange upon treatment patterns and clinical outcomes of glioblastoma patients
ConclusionEffective care coordination between neurosurgeons, oncologists, and PCPs may offer a modifiable avenue to improve GBM outcomes. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 25, 2024 Category: Cancer & Oncology Source Type: research
PUMC-MB1 is a novel group 3 medulloblastoma preclinical model, sensitive to PI3K/mTOR dual inhibitor
ConclusionsPUMC-MB1, a novel Group 3 (Non-WNT/Non-SHH) MB cell line, is comprehensively characterized for its growth, pathology, and molecular characteristics. Notably, dactolisib demonstrated potent anti-proliferative effects with minimal toxicity, promising a potential therapeutic avenue. PUMC-MB1 could serve as a valuable tool for unraveling MB mechanisms and innovative treatment strategies. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 25, 2024 Category: Cancer & Oncology Source Type: research
Single versus multiple reoperations for recurrent intracranial meningiomas
ConclusionThe extent of resection and the multicentric-diffuse pattern of regrowth at first recurrence are the main risk factors for multiple recurrences and reoperations. Repeated reoperations might be considered even in patients with extensive recurrent tumors before the anaplastic transformation occurs. In such cases, even partial tumor resections followed by radiation therapy may allow long survival in good clinical conditions. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 24, 2024 Category: Cancer & Oncology Source Type: research
Correction to: Maximal cardiopulmonary exercise testing in glioblastoma patients undergoing chemotherapy: assessment of feasibility, safety, and physical fitness status
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 24, 2024 Category: Cancer & Oncology Source Type: research
Genomic landscape of glioblastoma without IDH somatic mutation in 42 cases: a comprehensive analysis using RNA sequencing data
ConclusionRNA sequencing is a promising approach for genotyping glioblastomas because it provides comprehensive information on gene expression and is relatively cost-effective. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Suberanilohydroxamic acid (SAHA), a HDAC inhibitor, suppresses the effect of Treg cells by targeting the c-Myc/CCL1 pathway in glioma stem cells and improves PD-L1 blockade therapy
ConclusionSAHA inhibited the binding of c-Myc with the CCL1 promoter and then suppressed the transcription of CCL1.Additionally, it effectively blocked the interplay of CCL1-CCR8, resulting in reduced activity of Tregs and alleviation of tumor immunosuppression. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Intraoperative radiotherapy combined with spinal stabilization surgery —a novel treatment strategy for spinal metastases based on a first single-center experiences
Conclusion50 kV photon IORT for SM and consecutive unstable spine needing surgical intervention is safe and feasible and can be a promising technique in selected cases. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Screening and surveillance recommendations for central nervous system hemangioblastomas in pediatric patients with Von Hippel-Lindau disease
ConclusionWe recommend starting MRI imaging at the age of 12 years with examination intervals every (1-) 2 years depending on CNS involvement. Special attention should be paid to patients with truncating variants. Affected families should be educated regularly on potential tumor-associated symptoms to enable timely MRI imaging and eventually intervention, as CNS hemangioblastoma may develop before screening begins.German clinical trials Register registration numberDRKS00029553, date of registration 08/16/2022, retrospectively registered. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Impact of concurrent antibody –drug conjugates and radiotherapy on symptomatic radiation necrosis in breast cancer patients with brain metastases: a multicenter retrospective study
ConclusionsThis study suggests that concurrent ADC and radiotherapy are associated with a higher risk of SRN in HER2-positive breast cancer patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Comment in reply to Chen et al. Journal of Neuro-Oncology (2023) 165:535 –545 “Focused ultrasound combined with radiotherapy for malignant brain tumor: a preclinical and clinical study”
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Central nervous system embryonal tumors with EWSR1-PLAGL1 rearrangements reclassified as INI-1 deficient tumors at relapse
ConclusionCNS embryonal tumors with EWSR1-PLAGL1 rearrangements acquire or include a population of cells with SMARCB1 alterations that are the component that predominate at relapse, suggesting treatment aimed at this disease component at diagnosis should be considered. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Personalized prognosis stratification of newly diagnosed glioblastoma applying a statistical decision tree model
ConclusionA risk stratification algorithm based on significant prognostic factors allowed a personalized early prognosis estimation at the time of GBM diagnosis, that can contribute to a more personalized patient counseling. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
National trends in the treatment of adult diffuse midline gliomas: a rare clinical scenario
ConclusionsDespite being considered ineffective, chemotherapy is still administered in most adult patients diagnosed with DMG. Significant predictors of survival were Charlson-Deyo comorbidity index and race. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 17, 2024 Category: Cancer & Oncology Source Type: research
Improved outcomes for triple negative breast cancer brain metastases patients after stereotactic radiosurgery and new systemic approaches
ConclusionsTNBC patients with BM can achieve longer survival than might have been previously anticipated with median survival now surpassing one year. The use of immunotherapy is associated with increased median OS of 23 months. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 17, 2024 Category: Cancer & Oncology Source Type: research
