What can reactive oxygen species (ROS) tell us about the action mechanism of herbicides and other phytotoxins?
Free Radic Biol Med. 2024 Apr 23:S0891-5849(24)00412-X. doi: 10.1016/j.freeradbiomed.2024.04.233. Online ahead of print.ABSTRACTReactive oxygen species (ROS) are formed in plant cells continuously. When ROS production exceeds the antioxidant capacity of the cells, oxidative stress develops which causes damage of cell components and may even lead to the induction of programmed cell death (PCD). The levels of ROS production increase upon abiotic stress, but also during pathogen attack in response to elicitors, and upon application of toxic compounds such as synthetic herbicides or natural phytotoxins. The commercial value of...
Source: Free Radical Biology and Medicine - April 25, 2024 Category: Biology Authors: Valeria A Dmitrieva Elena V Tyutereva Olga V Voitsekhovskaja Source Type: research
Elevated levels of iodide promote peroxidase-mediated protein iodination and inhibit protein chlorination
Free Radic Biol Med. 2024 Apr 23:S0891-5849(24)00409-X. doi: 10.1016/j.freeradbiomed.2024.04.230. Online ahead of print.ABSTRACTAt inflammatory sites, immune cells generate oxidants including H₂O₂. Myeloperoxidase (MPO), released by activated leukocytes employs H₂O₂ and halide/pseudohalides to form hypohalous acids that mediate pathogen killing. Hypochlorous acid (HOCl) is a major species formed. Excessive or misplaced HOCl formation damages host tissues with this linked to multiple inflammatory diseases. Previously (Redox Biology, 2020, 28, 101331) we reported that iodide (I⁻) modulates MPO-mediated protein dama...
Source: Free Radical Biology and Medicine - April 25, 2024 Category: Biology Authors: Kathrine V Jokumsen Valerie H Huhle Per M H ägglund Michael J Davies Luke F Gamon Source Type: research
Rocaglamide regulates iron homeostasis by suppressing hepcidin expression
Free Radic Biol Med. 2024 Apr 23;219:153-162. doi: 10.1016/j.freeradbiomed.2024.04.232. Online ahead of print.ABSTRACTThe anemia of inflammation (AI) is characterized by the presence of inflammation and abnormal elevation of hepcidin. Accumulating evidence has proved that Rocaglamide (RocA) was involved in inflammation regulation. Nevertheless, the role of RocA in AI, especially in iron metabolism, has not been investigated, and its underlying mechanism remains elusive. Here, we demonstrated that RocA dramatically suppressed the elevation of hepcidin and ferritin in LPS-treated mice cell line RAW264.7 and peritoneal macrop...
Source: Free Radical Biology and Medicine - April 24, 2024 Category: Biology Authors: Xinyue Zhu Quan Zuo Xueting Xie Zhongxian Chen Lixin Wang Linyue Chang Yangli Liu Jiaojiao Luo Cheng Fang Linlin Che Xinyue Zhou Chao Yao Chenyuan Gong Dan Hu Weimin Zhao Yufu Zhou Shiguo Zhu Source Type: research
Fusobacterium nucleatum induces oxaliplatin resistance by inhibiting ferroptosis through E-cadherin/ β-catenin/GPX4 axis in colorectal cancer
Free Radic Biol Med. 2024 Apr 22:S0891-5849(24)00405-2. doi: 10.1016/j.freeradbiomed.2024.04.226. Online ahead of print.ABSTRACTFusobacterium (F.) nucleatum is a carcinogenesis microbiota in colorectal cancer (CRC). Growing evidence shows that F. nucleatum contributes to chemoresistance. Ferroptosis is reported to restore the susceptibility of resistant cells to chemotherapy. However, the role of gut microbiota affecting ferroptosis in chemoresistance remains unclear. Here, we examined the CRC tissues of patients using 16S rRNA sequencing to investigate the possible connection between gut microbiota dysbiosis and the relap...
Source: Free Radical Biology and Medicine - April 24, 2024 Category: Biology Authors: Bowen Li Zixian Wei Zhiyue Wang Fangqi Xu Jinhua Yang Baiqiang Lin Yu Chen Hubin Wenren Lingli Wu Xiao Guo Yang Liu Yunwei Wei Source Type: research
Carbon monoxide-loaded cell therapy as an exercise mimetic for sarcopenia treatment
Free Radic Biol Med. 2024 Apr 22:S0891-5849(24)00410-6. doi: 10.1016/j.freeradbiomed.2024.04.231. Online ahead of print.ABSTRACTSarcopenia is characterized by loss of muscle strength and muscle mass with aging. The growing number of sarcopenia patients as a result of the aging population has no viable treatment. Exercise maintains muscle strength and mass by increasing peroxisome growth factor activating receptor γ-conjugating factor-1α (PGC-1α) and Akt signaling in skeletal muscle. The present study focused on the carbon monoxide (CO), endogenous activator of PGC-1α and Akt, and investigated the therapeutic potential ...
Source: Free Radical Biology and Medicine - April 24, 2024 Category: Biology Authors: Isamu Noguchi Maeda Hitoshi Kazuki Kobayashi Taisei Nagasaki Hiromasa Kato Hiroki Yanagisawa Naoki Wada Gai Kanazawa Tsubasa Kaji Hiromi Sakai Shin Fujimaki Yusuke Ono Kazuaki Taguchi Victor Tuan Giam Chuang Junji Saruwatari Masaki Otagiri Hiroshi Watanab Source Type: research
TRPC4 aggravates hypoxic pulmonary hypertension by promoting pulmonary endothelial cell apoptosis
In this study, we aimed to investigate whether TRPC4 in PAECs has an aggravating effect on PH and elucidate the molecular mechanisms. We observed that hypoxia treatment promoted PAEC apoptosis through a caspase-12/endoplasmic reticulum stress (ERS)-dependent pathway. Knockdown of TRPC4 attenuated hypoxia-induced apoptosis and caspase-3/caspase-12 activity in PAECs. Accordingly, adeno-associated virus (AAV) serotype 6-mediated pulmonary endothelial TRPC4 silencing (AAV6-Tie-shRNA-TRPC4) or TRPC4 antagonist suppressed PH progression as evidenced by reduced right ventricular systolic pressure (RVSP), pulmonary vascular remode...
Source: Free Radical Biology and Medicine - April 18, 2024 Category: Biology Authors: Liu Yang Zeyu Peng Fanpeng Gong WenXin Yan Yi Shi Hanyi Li Chang Zhou Hong Yao Menglu Yuan Fan Yu Lei Feng Naifu Wan Guizhu Liu Source Type: research
Selenium maintains intestinal epithelial cells to activate M2 macrophages against deoxynivalenol injury
This study provides novel insights into how intestinal epithelial cells regulate the CSF-1-M2 macrophage pathway, which is essential in maintaining intestinal homeostasis confer to environmental hazardous stimuli.PMID:38636715 | DOI:10.1016/j.freeradbiomed.2024.04.228 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 18, 2024 Category: Biology Authors: Shijie Fan Jiaying Chen Huihui Tian Xinting Yang Longzhu Zhou Qingyu Zhao Yuchang Qin Junmin Zhang Chaohua Tang Source Type: research
iNOS regulates hematopoietic stem and progenitor cells via mitochondrial signaling and is critical for bone marrow regeneration
In conclusion, our study challenges the conventional view of iNOS-derived NO as a cytotoxic molecule and highlights its intriguing role in HSPCs. Together, our findings provide insights into the crucial role of the iNOS-NO-mitochondrial axis in regulating HSPCs and hematopoiesis.PMID:38636716 | DOI:10.1016/j.freeradbiomed.2024.04.225 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 18, 2024 Category: Biology Authors: Supriya Sinha Priyanka Dhankani Milind Nahiyera Krishna Bhan Singh Divya Singh Madhav Nilakanth Mugale Sharad Sharma Jagavelu Kumaravelu Madhu Dikshit Sachin Kumar Source Type: research
TRPC4 aggravates hypoxic pulmonary hypertension by promoting pulmonary endothelial cell apoptosis
In this study, we aimed to investigate whether TRPC4 in PAECs has an aggravating effect on PH and elucidate the molecular mechanisms. We observed that hypoxia treatment promoted PAEC apoptosis through a caspase-12/endoplasmic reticulum stress (ERS)-dependent pathway. Knockdown of TRPC4 attenuated hypoxia-induced apoptosis and caspase-3/caspase-12 activity in PAECs. Accordingly, adeno-associated virus (AAV) serotype 6-mediated pulmonary endothelial TRPC4 silencing (AAV6-Tie-shRNA-TRPC4) or TRPC4 antagonist suppressed PH progression as evidenced by reduced right ventricular systolic pressure (RVSP), pulmonary vascular remode...
Source: Free Radical Biology and Medicine - April 18, 2024 Category: Biology Authors: Liu Yang Zeyu Peng Fanpeng Gong WenXin Yan Yi Shi Hanyi Li Chang Zhou Hong Yao Menglu Yuan Fan Yu Lei Feng Naifu Wan Guizhu Liu Source Type: research
Selenium maintains intestinal epithelial cells to activate M2 macrophages against deoxynivalenol injury
This study provides novel insights into how intestinal epithelial cells regulate the CSF-1-M2 macrophage pathway, which is essential in maintaining intestinal homeostasis confer to environmental hazardous stimuli.PMID:38636715 | DOI:10.1016/j.freeradbiomed.2024.04.228 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 18, 2024 Category: Biology Authors: Shijie Fan Jiaying Chen Huihui Tian Xinting Yang Longzhu Zhou Qingyu Zhao Yuchang Qin Junmin Zhang Chaohua Tang Source Type: research
iNOS regulates hematopoietic stem and progenitor cells via mitochondrial signaling and is critical for bone marrow regeneration
In conclusion, our study challenges the conventional view of iNOS-derived NO as a cytotoxic molecule and highlights its intriguing role in HSPCs. Together, our findings provide insights into the crucial role of the iNOS-NO-mitochondrial axis in regulating HSPCs and hematopoiesis.PMID:38636716 | DOI:10.1016/j.freeradbiomed.2024.04.225 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 18, 2024 Category: Biology Authors: Supriya Sinha Priyanka Dhankani Milind Nahiyera Krishna Bhan Singh Divya Singh Madhav Nilakanth Mugale Sharad Sharma Jagavelu Kumaravelu Madhu Dikshit Sachin Kumar Source Type: research
Bridging clinical radiotherapy and space radiation therapeutics through reactive oxygen species (ROS)-triggered delivery
Free Radic Biol Med. 2024 Apr 15;219:88-103. doi: 10.1016/j.freeradbiomed.2024.04.219. Online ahead of print.ABSTRACTThis review explores the convergence of clinical radiotherapy and space radiation therapeutics, focusing on ionizing radiation (IR)-generated reactive oxygen species (ROS). IR, with high-energy particles, induces precise cellular damage, particularly in cancer treatments. The paper discusses parallels between clinical and space IR, highlighting unique characteristics of high-charge and energy particles in space and potential health risks for astronauts. Emphasizing the parallel occurrence of ROS generation i...
Source: Free Radical Biology and Medicine - April 17, 2024 Category: Biology Authors: Chloe Forenzo Jessica Larsen Source Type: research
sBridging Clinical Radiotherapy and Space Radiation Therapeutics through Reactive Oxygen Species (ROS)-Triggered Delivery
Free Radic Biol Med. 2024 Apr 15:S0891-5849(24)00390-3. doi: 10.1016/j.freeradbiomed.2024.04.219. Online ahead of print.ABSTRACTThis review explores the convergence of clinical radiotherapy and space radiation therapeutics, focusing on ionizing radiation (IR)-generated reactive oxygen species (ROS). IR, with high-energy particles, induces precise cellular damage, particularly in cancer treatments. The paper discusses parallels between clinical and space IR, highlighting unique characteristics of high-charge and energy particles in space and potential health risks for astronauts. Emphasizing the parallel occurrence of ROS g...
Source: Free Radical Biology and Medicine - April 17, 2024 Category: Biology Authors: Chloe Forenzo Jessica Larsen Source Type: research
RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes
CONCLUSIONS: The findings highlight RNF31's essential role in the regulation of mitochondrial homeostasis in hepatocytes, emphasizing its potential as a therapeutic target for NAFLD.PMID:38615890 | DOI:10.1016/j.freeradbiomed.2024.04.214 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 14, 2024 Category: Biology Authors: Yifei Chen Fuji Yang Yujie Shi Jingyu Sheng Yanjin Wang Liting Zhang Jing Zhou Yi Jin Yongmin Yan Source Type: research
RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes
CONCLUSIONS: The findings highlight RNF31's essential role in the regulation of mitochondrial homeostasis in hepatocytes, emphasizing its potential as a therapeutic target for NAFLD.PMID:38615890 | DOI:10.1016/j.freeradbiomed.2024.04.214 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 14, 2024 Category: Biology Authors: Yifei Chen Fuji Yang Yujie Shi Jingyu Sheng Yanjin Wang Liting Zhang Jing Zhou Yi Jin Yongmin Yan Source Type: research
