iNOS regulates hematopoietic stem and progenitor cells via mitochondrial signaling and is critical for bone marrow regeneration

In conclusion, our study challenges the conventional view of iNOS-derived NO as a cytotoxic molecule and highlights its intriguing role in HSPCs. Together, our findings provide insights into the crucial role of the iNOS-NO-mitochondrial axis in regulating HSPCs and hematopoiesis.PMID:38636716 | DOI:10.1016/j.freeradbiomed.2024.04.225

Source: Free Radical Biology and Medicine - April 18, 2024 Category: Biology Authors: Supriya Sinha Priyanka Dhankani Milind Nahiyera Krishna Bhan Singh Divya Singh Madhav Nilakanth Mugale Sharad Sharma Jagavelu Kumaravelu Madhu Dikshit Sachin Kumar Source Type: research