sBridging Clinical Radiotherapy and Space Radiation Therapeutics through Reactive Oxygen Species (ROS)-Triggered Delivery

Free Radic Biol Med. 2024 Apr 15:S0891-5849(24)00390-3. doi: 10.1016/j.freeradbiomed.2024.04.219. Online ahead of print.ABSTRACTThis review explores the convergence of clinical radiotherapy and space radiation therapeutics, focusing on ionizing radiation (IR)-generated reactive oxygen species (ROS). IR, with high-energy particles, induces precise cellular damage, particularly in cancer treatments. The paper discusses parallels between clinical and space IR, highlighting unique characteristics of high-charge and energy particles in space and potential health risks for astronauts. Emphasizing the parallel occurrence of ROS generation in both clinical and space contexts, the review identifies ROS as a crucial factor with dual roles in cellular responses and potential disease initiation. The analysis covers ROS generation mechanisms, variations, and similarities in terrestrial and extraterrestrial environments leading to innovative ROS-responsive delivery systems adaptable for both clinical and space applications. The paper concludes by discussing applications of personalized ROS-triggered therapeutic approaches and discussing the challenges and prospects of implementing these strategies in clinical radiotherapy and extraterrestrial missions. Overall, it underscores the potential of ROS-targeted delivery for advancing therapeutic strategies in terrestrial clinical settings and space exploration, contributing to human health improvement on Earth and beyond.PMID:38631648 | DOI:10.1...
Source: Free Radical Biology and Medicine - Category: Biology Authors: Source Type: research