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The role of mitochondrial dynamics and mitophagy in skeletal muscle atrophy: from molecular mechanisms to therapeutic insights
Cell Mol Biol Lett. 2024 Apr 23;29(1):59. doi: 10.1186/s11658-024-00572-y.ABSTRACTSkeletal muscle is the largest metabolic organ of the human body. Maintaining the best quality control and functional integrity of mitochondria is essential for the health of skeletal muscle. However, mitochondrial dysfunction characterized by mitochondrial dynamic imbalance and mitophagy disruption can lead to varying degrees of muscle atrophy, but the underlying mechanism of action is still unclear. Although mitochondrial dynamics and mitophagy are two different mitochondrial quality control mechanisms, a large amount of evidence has indica...
Source: Cellular and Molecular Biology Letters - April 23, 2024 Category: Biochemistry Authors: Yuhang Lei Mailin Gan Yanhao Qiu Qiuyang Chen Xingyu Wang Tianci Liao Mengying Zhao Lei Chen Shunhua Zhang Ye Zhao Lili Niu Yan Wang Li Zhu Linyuan Shen Source Type: research

Targeted inhibition of the PI3K/AKT/mTOR pathway by (+)-anthrabenzoxocinone induces cell cycle arrest, apoptosis, and autophagy in non-small cell lung cancer
Cell Mol Biol Lett. 2024 Apr 23;29(1):58. doi: 10.1186/s11658-024-00578-6.ABSTRACTNon-small cell lung cancer (NSCLC), characterized by low survival rates and a high recurrence rate, is a major cause of cancer-related mortality. Aberrant activation of the PI3K/AKT/mTOR signaling pathway is a common driver of NSCLC. Within this study, the inhibitory activity of (+)-anthrabenzoxocinone ((+)-ABX), an oxygenated anthrabenzoxocinone compound derived from Streptomyces, against NSCLC is demonstrated for the first time both in vitro and in vivo. Mechanistically, it is confirmed that the PI3K/AKT/mTOR signaling pathway is targeted a...
Source: Cellular and Molecular Biology Letters - April 22, 2024 Category: Biochemistry Authors: Xiao-Qian Li Xiao-Ju Cheng Jie Wu Kai-Feng Wu Tie Liu Source Type: research

A tomato NAC transcription factor, SlNAP1, directly regulates gibberellin-dependent fruit ripening
Cell Mol Biol Lett. 2024 Apr 23;29(1):57. doi: 10.1186/s11658-024-00577-7.ABSTRACTIn tomato (Solanum lycopersicum), the ripening of fruit is regulated by the selective expression of ripening-related genes, and this procedure is controlled by transcription factors (TFs). In the various plant-specific TF families, the no apical meristem (NAM), Arabidopsis thaliana activating factor 1/2 (ATAF1/2), and cup-shaped cotyledon 2 (CUC2; NAC) TF family stands out and plays a significant function in plant physiological activities, such as fruit ripening (FR). Despite the numerous genes of NAC found in the tomato genome, limited infor...
Source: Cellular and Molecular Biology Letters - April 22, 2024 Category: Biochemistry Authors: Changxia Li Xuemei Hou Zongxi Zhao Huwei Liu Panpan Huang Meimei Shi Xuetong Wu Rong Gao Zhiya Liu Lijuan Wei Yihua Li Weibiao Liao Source Type: research

Reciprocal negative feedback between Prrx1 and miR-140-3p regulates rapid chondrogenesis in the regenerating antler
Cell Mol Biol Lett. 2024 Apr 20;29(1):56. doi: 10.1186/s11658-024-00573-x.ABSTRACTDuring growth phase, antlers exhibit a very rapid rate of chondrogenesis. The antler is formed from its growth center reserve mesenchyme (RM) cells, which have been found to be the derivatives of paired related homeobox 1 (Prrx1)-positive periosteal cells. However, the underlying mechanism that drives rapid chondrogenesis is not known. Herein, the miRNA expression profiles and chromatin states of three tissue layers (RM, precartilage, and cartilage) at different stages of differentiation within the antler growth center were analyzed by RNA-se...
Source: Cellular and Molecular Biology Letters - April 20, 2024 Category: Biochemistry Authors: Pengfei Hu Guokun Zhang Hengxing Ba Jing Ren Jiping Li Zhen Wang Chunyi Li Source Type: research

miR-29b-3p regulates cardiomyocytes pyroptosis in CVB3-induced myocarditis through targeting DNMT3A
CONCLUSIONS: Our results demonstrate a correlation between the expression of DNMT3A and CVB3-induced pyroptosis in cardiomyocytes. These findings unveil a previously unidentified mechanism by which CVB3 induces cardiac injury through the regulation of miR-29b-3p/DNMT3A-mediated pyroptosis.PMID:38643118 | PMC:PMC11031889 | DOI:10.1186/s11658-024-00576-8 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 20, 2024 Category: Biochemistry Authors: Ya Wang Zhengyang Zhang Hui Li Min Wang Yuting Qiu Lili Lu Source Type: research

Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b
CONCLUSION: Our results support that Rab4b, by controlling the sorting of the cation-independent mannose-6-phosphate receptor towards VPS52 microdomains, confers a directional specificity for cargo carriers en route to the trans-Golgi network. Given the importance of the endocytic recycling in cell homeostasis, disruption of the Rab4b/Golgi-associated retrograde protein complex-dependent step could have serious consequences in pathologies.PMID:38627612 | PMC:PMC11020649 | DOI:10.1186/s11658-024-00574-w (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 16, 2024 Category: Biochemistry Authors: J érôme Gilleron Abderrahman Chafik Sandra Lacas-Gervais Jean-Fran çois Tanti Mireille Cormont Source Type: research

Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b
CONCLUSION: Our results support that Rab4b, by controlling the sorting of the cation-independent mannose-6-phosphate receptor towards VPS52 microdomains, confers a directional specificity for cargo carriers en route to the trans-Golgi network. Given the importance of the endocytic recycling in cell homeostasis, disruption of the Rab4b/Golgi-associated retrograde protein complex-dependent step could have serious consequences in pathologies.PMID:38627612 | DOI:10.1186/s11658-024-00574-w (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 16, 2024 Category: Biochemistry Authors: J érôme Gilleron Abderrahman Chafik Sandra Lacas-Gervais Jean-Fran çois Tanti Mireille Cormont Source Type: research

Role of reactive oxygen species in myelodysplastic syndromes
Cell Mol Biol Lett. 2024 Apr 14;29(1):53. doi: 10.1186/s11658-024-00570-0.ABSTRACTReactive oxygen species (ROS) serve as typical metabolic byproducts of aerobic life and play a pivotal role in redox reactions and signal transduction pathways. Contingent upon their concentration, ROS production not only initiates or stimulates tumorigenesis but also causes oxidative stress (OS) and triggers cellular apoptosis. Mounting literature supports the view that ROS are closely interwoven with the pathogenesis of a cluster of diseases, particularly those involving cell proliferation and differentiation, such as myelodysplastic syndro...
Source: Cellular and Molecular Biology Letters - April 14, 2024 Category: Biochemistry Authors: Qiangan Jing Chaoting Zhou Junyu Zhang Ping Zhang Yunyi Wu Junyu Zhou Xiangmin Tong Yanchun Li Jing Du Ying Wang Source Type: research

CRISPR-Cas9 applications in T cells and adoptive T cell therapies
Cell Mol Biol Lett. 2024 Apr 12;29(1):52. doi: 10.1186/s11658-024-00561-1.ABSTRACTT cell immunity is central to contemporary cancer and autoimmune therapies, encompassing immune checkpoint blockade and adoptive T cell therapies. Their diverse characteristics can be reprogrammed by different immune challenges dependent on antigen stimulation levels, metabolic conditions, and the degree of inflammation. T cell-based therapeutic strategies are gaining widespread adoption in oncology and treating inflammatory conditions. Emerging researches reveal that clustered regularly interspaced palindromic repeats-associated protein 9 (C...
Source: Cellular and Molecular Biology Letters - April 12, 2024 Category: Biochemistry Authors: Xiaoying Chen Shuhan Zhong Yonghao Zhan Xuepei Zhang Source Type: research

Methylated lncRNAs suppress apoptosis of gastric cancer stem cells via the lncRNA-miRNA/protein axis
CONCLUSIONS: Our study revealed the requirement for site-specific methylation of lncRNAs in the tumorigenesis of GCSCs, contributing novel insights into cancer development.PMID:38600465 | PMC:PMC11005211 | DOI:10.1186/s11658-024-00568-8 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 10, 2024 Category: Biochemistry Authors: Yuan Ci Yuan Zhang Xiaobo Zhang Source Type: research

Correction: A multiplex RPA-CRISPR/Cas12a-based POCT technique and its application in human papillomavirus (HPV) typing assay
Cell Mol Biol Lett. 2024 Apr 9;29(1):49. doi: 10.1186/s11658-024-00567-9.NO ABSTRACTPMID:38594613 | PMC:PMC11005147 | DOI:10.1186/s11658-024-00567-9 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 9, 2024 Category: Biochemistry Authors: Yan Liu Zhujun Chao Wei Ding Tanfeng Fang Xinxian Gu Man Xue Wei Wang Rong Han Wanping Sun Source Type: research