Unraveling the structure-chirality sensing relationship between achiral anthracene-based tetracationic nanotubes and nucleosides in aqueous host-guest complexation
This study provides insights for the construction of adaptive chirality from achiral nanotubes with dynamic conformational nature and might facilitate further design of chiral functional materials for several applications.PMID:38705071 | DOI:10.1016/j.bios.2024.116342 (Source: Biosensors and Bioelectronics)
Source: Biosensors and Bioelectronics - May 5, 2024 Category: Biotechnology Authors: Ting Yang Honghong Duan Hao Nian Pingxia Wang Chaochao Yan Fan Cao Qingfang Li Liping Cao Source Type: research
Bilateral efforts to improve SERS detection efficiency of exosomes by Au/Na < sub > 7 < /sub > PMo < sub > 11 < /sub > O < sub > 39 < /sub > Combined with Phospholipid Epitope Imprinting
Biosens Bioelectron. 2024 Apr 29;258:116349. doi: 10.1016/j.bios.2024.116349. Online ahead of print.ABSTRACTDetection of cancer-related exosomes in body fluids has become a revolutionary strategy for early cancer diagnosis and prognosis prediction. We have developed a two-step targeting detection method, termed PS-MIPs-NELISA SERS, for rapid and highly sensitive exosomes detection. In the first step, a phospholipid polar site imprinting strategy was employed using magnetic PS-MIPs (phospholipids-molecularly imprinted polymers) to selectively isolate and enrich all exosomes from urine samples. In the second step, a nanozyme...
Source: Biosensors and Bioelectronics - May 5, 2024 Category: Biotechnology Authors: Qingnan Zhao Xianhui Cheng Saizhen Hu Menghan Zhao Junjie Chen Ming Mu Yumei Yang Hao Liu Lianghai Hu Bing Zhao Wei Song Source Type: research
Dual-ligand Eu-MOF/CuS@Au Heterostructure Array-based ECL Sensor for MiRNA-128 Detection in Glioblastoma Tissues
Biosens Bioelectron. 2024 May 1;258:116356. doi: 10.1016/j.bios.2024.116356. Online ahead of print.ABSTRACTIn this work, the dual-ligand lanthanide metal-organic framework (MOF)-based electrochemiluminescence (ECL) sensor was constructed for the detection of miRNA-128 in glioblastoma (GBM) diagnosis. The luminescent Eu-MOF (EuBBN) was synthesized with terephthalic acid (BDC) and 2-amino terephthalic acid (BDC-NH2) as dual-ligand. Due to the antenna effect, EuBBN with conjugated-π structure exhibited strong luminescent signal and high quantum efficiency, which can be employed as ECL nanoprobe. Furthermore, the novel plasmo...
Source: Biosensors and Bioelectronics - May 5, 2024 Category: Biotechnology Authors: Wenyan Li Zihui Liang Peilin Wang Zhenrun Li Qiang Ma Source Type: research
Fe-single-atom catalysts boosting electrochemiluminescence via bipolar electrode integrated with its peroxidase-like activity for bioanalysis
Biosens Bioelectron. 2024 Apr 30;258:116351. doi: 10.1016/j.bios.2024.116351. Online ahead of print.ABSTRACTMultifunctional single-atom catalysts (SACs) have been extensively investigated as outstanding signal amplifiers in bioanalysis field. Herein, a type of Fe single-atom catalysts with Fe-nitrogen coordination sites in nitrogen-doped carbon (Fe-N/C SACs) was synthesized and demonstrated to possess both catalase and peroxidase-like activity. Utilizing Fe-N/C SACs as dual signal amplifier, an efficient bipolar electrode (BPE)-based electrochemiluminescence (ECL) immunoassay was presented for determination of prostate-spe...
Source: Biosensors and Bioelectronics - May 5, 2024 Category: Biotechnology Authors: Xiaodong Chen Huijuan Xv Can Li Linghui Kong Chunxiang Li Feng Li Source Type: research
Carbon nanotubes integrated photonic barcodes in Herringbone Microfluidics for Multiplex Biomarker Quantification
In this study, we propose a novel herringbone microfluid chip with aptamer functionalized core-shell photonic crystal (PhC) barcode integration for high throughput multiplex CVD detection. Based on the PhC derived from co-assembled carboxylated single-wall carbon nanotubes and silicon dioxide nanoparticles, we obtain core-shell PhC barcodes by hydrogel replicating and partially etching. These core-shell PhC barcodes not only retain the original structural colors coding element, but also fully expose a large number of carboxyl elements in the ore for the probe immobilization. We further combine the functionalized barcodes w...
Source: Biosensors and Bioelectronics - May 5, 2024 Category: Biotechnology Authors: Xueqin Li Rui Liu Nan Zhang Junqi Zhao Yuanyang Zhou Qing Zhou Zhuxiao Gu Dagan Zhang Source Type: research
Detecting normal and cancer skin cells via glycosylation and adhesion signatures: A path to enhanced microfluidic phenotyping
Biosens Bioelectron. 2024 Apr 25;258:116337. doi: 10.1016/j.bios.2024.116337. Online ahead of print.ABSTRACTRecruiting circulating cells based on interactions between surface receptors and corresponding ligands holds promise for capturing cells with specific adhesive properties. Our study investigates the adhesion of skin cells to specific lectins, particularly focusing on advancements in lectin-based biosensors with diagnostic potential. We explore whether we can successfully capture normal skin (melanocytes and keratinocytes) and melanoma (WM35, WM115, WM266-4) cells in a low-shear flow environment by coating surfaces wi...
Source: Biosensors and Bioelectronics - May 4, 2024 Category: Biotechnology Authors: Renata Szydlak Marcin Luty Victorien E Prot Ingrid H Øvreeide Joanna Zem ła Bj ørn T Stokke Ma łgorzata Lekka Source Type: research
Rapid prototyping and facile customization of conductive hydrogel bioelectronics based on all laser process
Biosens Bioelectron. 2024 Apr 25;258:116327. doi: 10.1016/j.bios.2024.116327. Online ahead of print.ABSTRACTProper customization in size and shape is essential in implantable bioelectronics for stable bio-signal recording. Over the past decades, many researchers have heavily relied on conventional photolithography processes to fabricate implantable bioelectronics. Therefore, they could not avoid the critical limitation of high cost and complex processing steps to optimize bioelectronic devices for target organs with various sizes and shapes. Here, we propose rapid prototyping using all laser processes to fabricate customiz...
Source: Biosensors and Bioelectronics - May 4, 2024 Category: Biotechnology Authors: Jin Kim Daeyeon Won Tae Hyun Kim C-Yoon Kim Seung Hwan Ko Source Type: research
Reduced graphene oxide electrodes meet lateral flow assays: A promising path to advanced point-of-care diagnostics
Biosens Bioelectron. 2024 Apr 24;258:116315. doi: 10.1016/j.bios.2024.116315. Online ahead of print.ABSTRACTResearch in electrochemical detection in lateral flow assays (LFAs) has gained significant momentum in recent years. The primary impetus for this surge in interest is the pursuit of achieving lower limits of detection, especially given that LFAs are the most widely employed point-of-care biosensors. Conventionally, the strategy for merging electrochemistry and LFAs has centered on the superposition of screen-printed electrodes onto nitrocellulose substrates during LFA fabrication. Nevertheless, this approach poses su...
Source: Biosensors and Bioelectronics - May 3, 2024 Category: Biotechnology Authors: Enric Calucho Ruslan Álvarez-Diduk Andrew Piper Marianna Rossetti Tarja K Nevanen Arben Merko çi Source Type: research
Remote optogenetic control of the enteric nervous system and brain-gut axis in freely-behaving mice enabled by a wireless, battery-free optoelectronic device
We report here the development of a fully implantable, battery-free wireless device specifically designed for optogenetic control of the GI-tract, capable of generating sufficient light over large areas to robustly activate the ENS, potently inducing colonic motility ex vivo and increased propulsion in vivo. Use in in vivo studies reveals unique stimulation patterns that increase expulsion of colonic content, likely mediated in part by activation of an extrinsic brain-gut motor pathway, via pelvic nerves. This technology overcomes major limitations of conventional wireless optogenetic hardware designed for the CNS, providi...
Source: Biosensors and Bioelectronics - May 3, 2024 Category: Biotechnology Authors: Andrew I Efimov Timothy J Hibberd Yue Wang Mingzheng Wu Kaiqing Zhang Kaila Ting Surabhi Madhvapathy Min-Kyu Lee Joohee Kim Jiheon Kang Mohammad Riahi Haohui Zhang Lee Travis Emily J Govier Lianye Yang Nigel Kelly Yonggang Huang Abraham V ázquez-Guardado Source Type: research
Massive field-of-view sub-cellular traction force videography enabled by Single-Pixel Optical Tracers (SPOT)
We report a massive field-of-view and high-speed videography platform for measuring the sub-cellular traction forces of more than 10,000 biological cells over 13 mm2 at 83 frames per second. Our Single-Pixel Optical Tracers (SPOT) tool uses 2-dimensional diffraction gratings embedded into a soft substrate to convert cells' mechanical traction force into optical colors detectable by a video camera. The platform measures the sub-cellular traction forces of diverse cell types, including tightly connected tissue sheets and near isolated cells. We used this platform to explore the mechanical wave propagation in a tightly connec...
Source: Biosensors and Bioelectronics - May 3, 2024 Category: Biotechnology Authors: Xing Haw Marvin Tan Yijie Wang Xiongfeng Zhu Felipe Nanni Mendes Pei-Shan Chung Yu Ting Chow Tianxing Man Hsin Lan Yen-Ju Lin Xiang Zhang Xiaohe Zhang Thang Nguyen Reza Ardehali Michael A Teitell Arjun Deb Pei-Yu Chiou Source Type: research
Reduced graphene oxide electrodes meet lateral flow assays: A promising path to advanced point-of-care diagnostics
Biosens Bioelectron. 2024 Apr 24;258:116315. doi: 10.1016/j.bios.2024.116315. Online ahead of print.ABSTRACTResearch in electrochemical detection in lateral flow assays (LFAs) has gained significant momentum in recent years. The primary impetus for this surge in interest is the pursuit of achieving lower limits of detection, especially given that LFAs are the most widely employed point-of-care biosensors. Conventionally, the strategy for merging electrochemistry and LFAs has centered on the superposition of screen-printed electrodes onto nitrocellulose substrates during LFA fabrication. Nevertheless, this approach poses su...
Source: Biosensors and Bioelectronics - May 3, 2024 Category: Biotechnology Authors: Enric Calucho Ruslan Álvarez-Diduk Andrew Piper Marianna Rossetti Tarja K Nevanen Arben Merko çi Source Type: research
Remote optogenetic control of the enteric nervous system and brain-gut axis in freely-behaving mice enabled by a wireless, battery-free optoelectronic device
We report here the development of a fully implantable, battery-free wireless device specifically designed for optogenetic control of the GI-tract, capable of generating sufficient light over large areas to robustly activate the ENS, potently inducing colonic motility ex vivo and increased propulsion in vivo. Use in in vivo studies reveals unique stimulation patterns that increase expulsion of colonic content, likely mediated in part by activation of an extrinsic brain-gut motor pathway, via pelvic nerves. This technology overcomes major limitations of conventional wireless optogenetic hardware designed for the CNS, providi...
Source: Biosensors and Bioelectronics - May 3, 2024 Category: Biotechnology Authors: Andrew I Efimov Timothy J Hibberd Yue Wang Mingzheng Wu Kaiqing Zhang Kaila Ting Surabhi Madhvapathy Min-Kyu Lee Joohee Kim Jiheon Kang Mohammad Riahi Haohui Zhang Lee Travis Emily J Govier Lianye Yang Nigel Kelly Yonggang Huang Abraham V ázquez-Guardado Source Type: research
Massive field-of-view sub-cellular traction force videography enabled by Single-Pixel Optical Tracers (SPOT)
We report a massive field-of-view and high-speed videography platform for measuring the sub-cellular traction forces of more than 10,000 biological cells over 13 mm2 at 83 frames per second. Our Single-Pixel Optical Tracers (SPOT) tool uses 2-dimensional diffraction gratings embedded into a soft substrate to convert cells' mechanical traction force into optical colors detectable by a video camera. The platform measures the sub-cellular traction forces of diverse cell types, including tightly connected tissue sheets and near isolated cells. We used this platform to explore the mechanical wave propagation in a tightly connec...
Source: Biosensors and Bioelectronics - May 3, 2024 Category: Biotechnology Authors: Xing Haw Marvin Tan Yijie Wang Xiongfeng Zhu Felipe Nanni Mendes Pei-Shan Chung Yu Ting Chow Tianxing Man Hsin Lan Yen-Ju Lin Xiang Zhang Xiaohe Zhang Thang Nguyen Reza Ardehali Michael A Teitell Arjun Deb Pei-Yu Chiou Source Type: research
Sensing patches for biomarker identification in skin-derived biofluids
Biosens Bioelectron. 2024 Apr 22;258:116326. doi: 10.1016/j.bios.2024.116326. Online ahead of print.ABSTRACTIn conventional clinical disease diagnosis and screening based on biomarker detection, most analysis samples are collected from serum, blood. However, these invasive collection methods require specific instruments, professionals, and may lead to infection risks. Additionally, the diagnosis process suffers from untimely results. The identification of skin-related biomarkers plays an unprecedented role in early disease diagnosis. More importantly, these skin-mediated approaches for collecting biomarker-containing biofl...
Source: Biosensors and Bioelectronics - May 2, 2024 Category: Biotechnology Authors: Chen Wei Danni Fu Tianyue Ma Mo Chen Fangling Wang Guojun Chen Zejun Wang Source Type: research
Development of a thermotaxis and rheotaxis microfluidic device for motile spermatozoa sorting
This study introduces a groundbreaking development in the form of a thermotaxis and rheotaxis microfluidic (TRMC) device designed for efficient motile spermatozoa sorting within a short 15-min timeframe. The TRMC device mimics the natural sperm sorting mechanism of the oviduct, selecting spermatozoa with superior motility and DNA integrity. The experimental outcomes demonstrate a remarkable enhancement in the percentage of progressive spermatozoa following sorting, soaring from 3.90% to an impressive 96.11% when subjected to a temperature decrease from 38 °C to 35 °C. Notably, sperm motility exhibited a substantial 69% i...
Source: Biosensors and Bioelectronics - May 2, 2024 Category: Biotechnology Authors: Teng-Kuan Huang Chung-Hsien Huang Pei-An Chen Ching Hung Chen Farn Lu Wen-Ju Yang Jack Yu Jen Huang Bor-Ran Li Source Type: research
