Perovskite hydroxide-based laccase mimics with controllable activity for environmental remediation and biosensing
Biosens Bioelectron. 2024 Apr 7;256:116275. doi: 10.1016/j.bios.2024.116275. Online ahead of print.ABSTRACTConstructing relatively inexpensive nanomaterials to simulate the catalytic performance of laccase is of great significance in recent years. Although research on improving laccase-like activity by regulating ligands of copper (amino acids or small organic molecules, etc.) have achieved remarkable success. There are few reports on improving laccase-like activity by adjusting the composition of metal Cu. Here, we used perovskite hydroxide AB(OH)6 as a model to evaluate the relationship between Cu based alloys and their ...
Source: Biosensors and Bioelectronics - April 11, 2024 Category: Biotechnology Authors: Yufeng Liu Jing Zhang Shuai Cui Hui Wei Dongzhi Yang Source Type: research
An integrated wearable differential microneedle array for continuous glucose monitoring in interstitial fluids
Biosens Bioelectron. 2024 Apr 9;256:116280. doi: 10.1016/j.bios.2024.116280. Online ahead of print.ABSTRACTMonitoring biomarkers in human interstitial fluids (ISF) using microneedle sensors has been extensively studied. However, most of the previous studies were limited to simple in vitro demonstrations and lacked system integration and analytical performance. Here we report a miniaturized, high-precision, fully integrated wearable electrochemical microneedle sensing device that works with a customized smartphone application to wirelessly and in real-time monitor glucose in human ISF. A microneedle array fabrication method...
Source: Biosensors and Bioelectronics - April 11, 2024 Category: Biotechnology Authors: Yong Yang Can Sheng Fang Dong Sheng Liu Source Type: research
Perovskite hydroxide-based laccase mimics with controllable activity for environmental remediation and biosensing
Biosens Bioelectron. 2024 Apr 7;256:116275. doi: 10.1016/j.bios.2024.116275. Online ahead of print.ABSTRACTConstructing relatively inexpensive nanomaterials to simulate the catalytic performance of laccase is of great significance in recent years. Although research on improving laccase-like activity by regulating ligands of copper (amino acids or small organic molecules, etc.) have achieved remarkable success. There are few reports on improving laccase-like activity by adjusting the composition of metal Cu. Here, we used perovskite hydroxide AB(OH)6 as a model to evaluate the relationship between Cu based alloys and their ...
Source: Biosensors and Bioelectronics - April 11, 2024 Category: Biotechnology Authors: Yufeng Liu Jing Zhang Shuai Cui Hui Wei Dongzhi Yang Source Type: research
An integrated wearable differential microneedle array for continuous glucose monitoring in interstitial fluids
Biosens Bioelectron. 2024 Apr 9;256:116280. doi: 10.1016/j.bios.2024.116280. Online ahead of print.ABSTRACTMonitoring biomarkers in human interstitial fluids (ISF) using microneedle sensors has been extensively studied. However, most of the previous studies were limited to simple in vitro demonstrations and lacked system integration and analytical performance. Here we report a miniaturized, high-precision, fully integrated wearable electrochemical microneedle sensing device that works with a customized smartphone application to wirelessly and in real-time monitor glucose in human ISF. A microneedle array fabrication method...
Source: Biosensors and Bioelectronics - April 11, 2024 Category: Biotechnology Authors: Yong Yang Can Sheng Fang Dong Sheng Liu Source Type: research
Highly sensitive and selective demethylase FTO detection using a DNAzyme-mediated CRISPR/Cas12a signal cascade amplification electrochemiluminescence biosensor with C-CN/PCN < sub > V < /sub > heterojunction as emitter
In this study, an electrochemiluminescence (ECL) biosensor for the detection of demethylase FTO was developed based on DNAzyme-mediated CRISPR/Cas12a signal cascade amplification system and carboxylated carbon nitride nanosheets/phosphorus-doped nitrogen-vacancy modified carbon nitride nanosheets (C-CN/PCNV) heterojunction as the emitter. The biosensor was constructed by modifying the C-CN/PCNV heterojunction and a ferrocene-tagged probe (ssDNA-Fc) on a glassy carbon electrode. The presence of FTO removes the m6A modification on the catalytic core of DNAzyme, restoring its cleavage activity and generating activator DNA. Th...
Source: Biosensors and Bioelectronics - April 10, 2024 Category: Biotechnology Authors: Hong Li Shuai Qiao Heng Zhang Yanxia Qiao Jin Liu Yan Li Source Type: research
A photoelectrochemical biosensor based on self-calibration platform of carbon-rich plasmonic probe with near-infrared driving signal amplification
Biosens Bioelectron. 2024 Apr 7;256:116274. doi: 10.1016/j.bios.2024.116274. Online ahead of print.ABSTRACTExploring the photochemical (PEC) method induced by low-energy light source makes great significance to achieve high stability and accurate analysis. A sensing platform driven by near-infrared (NIR) light was designed by making the biochemically encoded carbon rich plasmonic hybrid (CPH) probe, the peptide@C-Mo2C. The inherent plasmonic effect of C-Mo2C CPH can directly absorb NIR light, thus starting effective electronic-hole pairs separation. Moreover, the photothermal effect of C-Mo2C CPH also promoted the reaction...
Source: Biosensors and Bioelectronics - April 10, 2024 Category: Biotechnology Authors: Yanjie Chen Yitian Huang Shupei Zhang Lihong Gao Hong Dai Source Type: research
Coreactant-free aggregation-induced electrochemiluminescence system based on the novel zinc-luminol metal-organic gel for ultrasensitive detection of PiRNA-823
Biosens Bioelectron. 2024 Apr 4;255:116263. doi: 10.1016/j.bios.2024.116263. Online ahead of print.ABSTRACTAggregation-induced electrochemiluminescence (AIECL) technology has aroused widespread interest due to the significant improve in ECL response by solving the problems of aggregation-caused quenching and poor water solubility of the luminophore. However, the existing AIECL emitters still suffer from low ECL efficiency, additional coreactants and complex synthesis steps, which greatly limit their applications. Herein, luminol, as a kind of AIE molecule, was assembled with Zn2+ nodes to obtain a novel microflower-like Zi...
Source: Biosensors and Bioelectronics - April 9, 2024 Category: Biotechnology Authors: Congyi Hu Liping Cao Xinjie Wu Gaoxu Chen Yuanfang Li Jian Wang Chengzhi Huang Lei Zhan Source Type: research
Coreactant-free aggregation-induced electrochemiluminescence system based on the novel zinc-luminol metal-organic gel for ultrasensitive detection of PiRNA-823
Biosens Bioelectron. 2024 Apr 4;255:116263. doi: 10.1016/j.bios.2024.116263. Online ahead of print.ABSTRACTAggregation-induced electrochemiluminescence (AIECL) technology has aroused widespread interest due to the significant improve in ECL response by solving the problems of aggregation-caused quenching and poor water solubility of the luminophore. However, the existing AIECL emitters still suffer from low ECL efficiency, additional coreactants and complex synthesis steps, which greatly limit their applications. Herein, luminol, as a kind of AIE molecule, was assembled with Zn2+ nodes to obtain a novel microflower-like Zi...
Source: Biosensors and Bioelectronics - April 9, 2024 Category: Biotechnology Authors: Congyi Hu Liping Cao Xinjie Wu Gaoxu Chen Yuanfang Li Jian Wang Chengzhi Huang Lei Zhan Source Type: research
Hepatocellular carcinoma biomarkers screening based on hydrogel photonic barcodes with tyramine deposition amplified ELISA
Biosens Bioelectron. 2024 Apr 4;255:116270. doi: 10.1016/j.bios.2024.116270. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC), as one of the most lethal cancers, significantly impacts human health. Attempts in this area tends to develop novel technologies with sensitive and multiplexed detection properties for early diagnosis. Here, we present novel hydrogel photonic crystal (PhC) barcodes with tyramine deposition amplified enzyme-linked immunosorbent assay (ELISA) for highly sensitive and multiplexed HCC biomarker screening. Because of the abundant amino groups of acrylic acid (AA) component, the constructed h...
Source: Biosensors and Bioelectronics - April 8, 2024 Category: Biotechnology Authors: Wenjing Xue Li Wang Kexin Yi Lingyu Sun Haozhen Ren Feika Bian Source Type: research
Metabolism-triggered sensor array aided by machine learning for rapid identification of pathogens
Biosens Bioelectron. 2024 Apr 6;255:116264. doi: 10.1016/j.bios.2024.116264. Online ahead of print.ABSTRACTChemical-nose strategy has achieved certain success in the discrimination and identification of pathogens. However, this strategy usually relies on non-specific interactions, which are prone to be significantly disturbed by the change of environment thus limiting its practical usefulness. Herein, we present a novel chemical-nose sensing approach leveraging the difference in the dynamic metabolic variation during peptidoglycan metabolism among different species for rapid pathogen discrimination. Pathogens were first te...
Source: Biosensors and Bioelectronics - April 8, 2024 Category: Biotechnology Authors: Xin Wang Huida Li Chengxin Wu Jianyu Yang Jianhua Wang Ting Yang Source Type: research
Hepatocellular carcinoma biomarkers screening based on hydrogel photonic barcodes with tyramine deposition amplified ELISA
Biosens Bioelectron. 2024 Apr 4;255:116270. doi: 10.1016/j.bios.2024.116270. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC), as one of the most lethal cancers, significantly impacts human health. Attempts in this area tends to develop novel technologies with sensitive and multiplexed detection properties for early diagnosis. Here, we present novel hydrogel photonic crystal (PhC) barcodes with tyramine deposition amplified enzyme-linked immunosorbent assay (ELISA) for highly sensitive and multiplexed HCC biomarker screening. Because of the abundant amino groups of acrylic acid (AA) component, the constructed h...
Source: Biosensors and Bioelectronics - April 8, 2024 Category: Biotechnology Authors: Wenjing Xue Li Wang Kexin Yi Lingyu Sun Haozhen Ren Feika Bian Source Type: research
Metabolism-triggered sensor array aided by machine learning for rapid identification of pathogens
Biosens Bioelectron. 2024 Apr 6;255:116264. doi: 10.1016/j.bios.2024.116264. Online ahead of print.ABSTRACTChemical-nose strategy has achieved certain success in the discrimination and identification of pathogens. However, this strategy usually relies on non-specific interactions, which are prone to be significantly disturbed by the change of environment thus limiting its practical usefulness. Herein, we present a novel chemical-nose sensing approach leveraging the difference in the dynamic metabolic variation during peptidoglycan metabolism among different species for rapid pathogen discrimination. Pathogens were first te...
Source: Biosensors and Bioelectronics - April 8, 2024 Category: Biotechnology Authors: Xin Wang Huida Li Chengxin Wu Jianyu Yang Jianhua Wang Ting Yang Source Type: research
Two-dimensional metal-organic framework nanozyme-mediated portable paper-based analytical device for dichlorophen assay
Biosens Bioelectron. 2024 Apr 3;255:116271. doi: 10.1016/j.bios.2024.116271. Online ahead of print.ABSTRACTThe metal-organic frameworks (MOFs) nanozyme-mediated paper-based analytical devices (PADs) have shown great potential in portable visual determination of phenolic compounds in the environment. However, most MOF nanozymes suffer from poor dispersibility and block-like structure, which often prompts deposition and results in diminished enzymatic activity, severely hindering their environmental applications. Here, we proposed colorimetric PADs for the visual detection of dichlorophen (Dcp) based on its significant inhib...
Source: Biosensors and Bioelectronics - April 7, 2024 Category: Biotechnology Authors: Jiafu Chang Ruixian Hu Jinyan Zhang Ting Hou Feng Li Source Type: research
Detection of SARS-CoV-2 using machine learning-enabled paper-assisted ratiometric fluorescent sensors based on target-induced magnetic DNAzyme
Biosens Bioelectron. 2024 Apr 4;255:116272. doi: 10.1016/j.bios.2024.116272. Online ahead of print.ABSTRACTThe development of an advanced analytical platform with regard to SARS-CoV-2 is crucial for public health. Herein, we present a machine learning platform based on paper-assisted ratiometric fluorescent sensors for highly sensitive detection of the SARS-CoV-2 RdRp gene. The assay involves target-induced rolling circle amplification to generate magnetic DNAzyme, which is then detectable using the paper-assisted ratiometric fluorescent sensor. This sensor detects the SARS-CoV-2 RdRp gene with a visible-fluorescence color...
Source: Biosensors and Bioelectronics - April 6, 2024 Category: Biotechnology Authors: Wenhai Wang Lun Luo Yanmei Li Bin Hong Yi Ma Keren Kang Jufang Wang Source Type: research
Flexible low-profile external ventricular drain catheter for real-time brain monitoring
Biosens Bioelectron. 2024 Apr 2;255:116267. doi: 10.1016/j.bios.2024.116267. Online ahead of print.ABSTRACTExternal ventricular drainage is one of the most common neurosurgical procedures in the world for acute hydrocephalus, which must be performed carefully by a neurosurgeon. Although various neuromonitoring external ventricular drain (EVD) catheters have been utilized, they still suffer from rigidity and bulkiness to mitigate post-EVD placement trauma. Here, we introduce a flexible and low-profile smart EVD catheter using a class of technologies with sensitive electrical materials, seamless integration, and flexible mec...
Source: Biosensors and Bioelectronics - April 6, 2024 Category: Biotechnology Authors: Hoon Yi Hodam Kim Ka Ram Kim Ju Hyeon Kim Juhee Kim Hyunjae Lee Sanjeet S Grewal William D Freeman Woon-Hong Yeo Source Type: research
