Making commercial bracelet smarter with a biochemical button module
Biosens Bioelectron. 2024 Feb 29;253:116163. doi: 10.1016/j.bios.2024.116163. Online ahead of print.ABSTRACTDespite the rapid development of mobile health based on wearable devices in recent years, lack of access to biochemical detection remains a vital challenge for most commercial wearable devices, which hinders the provision of effective electronic health records (EHRs) for disease control strategies, and further constraining the development of personalized precision medicine. Herein, we propose a strategy to graft biochemical detection function onto commercial bracelet. Different from the conventional development proce...
Source: Biosensors and Bioelectronics - March 8, 2024 Category: Biotechnology Authors: Junhao Chen Xunshun Tao Xiaohu Xu Linan Sun Ruquan Huang Azadeh Nilghaz Junfei Tian Source Type: research
Cascade reaction triggered colorimetric array for identification of organophosphorus pesticides congeners
Biosens Bioelectron. 2024 Feb 24;253:116143. doi: 10.1016/j.bios.2024.116143. Online ahead of print.ABSTRACTA modern agriculture uses alternative pest control methods to boost productivity, leading to an accumulation of organophosphorus (OPPs) congeners. This necessitates an intuitive and quick way to identify OPPs congeners. A colorimetric sensor for detecting OPPs congeners using a double-enzyme cascade reaction has been successfully designed and constructed in this study. The OPPs regulate the color changes induced by manganese dioxide nanoflowers (MnO2 NFs) and specific alkaline phosphatases (ALP) during the etching of...
Source: Biosensors and Bioelectronics - March 7, 2024 Category: Biotechnology Authors: Zikang Chen Ming Li Weiwei Chen Jingyi Zhou Xungang Gu Caiping Ding Youju Huang Source Type: research
Multifunctional self-priming hairpin probe-based isothermal nucleic acid amplification and its applications for COVID-19 diagnosis
Biosens Bioelectron. 2024 Feb 20;253:116147. doi: 10.1016/j.bios.2024.116147. Online ahead of print.ABSTRACTWe herein present a multifunctional self-priming hairpin probe-based isothermal amplification, termed MSH, enabling one-pot detection of target nucleic acids. The sophisticatedly designed multifunctional self-priming hairpin (MSH) probe recognizes the target and rearranges to prime itself, triggering the amplification reaction powered by the continuously repeated extension, nicking, and target recycling. As a consequence, a large number of double-stranded DNA (dsDNA) amplicons are produced that could be monitored in ...
Source: Biosensors and Bioelectronics - March 7, 2024 Category: Biotechnology Authors: Hansol Kim Seoyoung Lee Yong Ju Hyoyong Kim Hyowon Jang Yeonkyung Park Sang Mo Lee Dongeun Yong Taejoon Kang Hyun Gyu Park Source Type: research
Electrochemical biosensor using direct electron transfer and an antibody-aptamer hybrid sandwich for target detection in complex biological samples
Biosens Bioelectron. 2024 Mar 3;253:116184. doi: 10.1016/j.bios.2024.116184. Online ahead of print.ABSTRACTDirect electron transfer (DET) between an electrode and redox labels is feasible in electrochemical biosensors using small aptamer-aptamer sandwiches; however, its application is limited in biosensors that rely on larger antibody-antibody sandwiches. The development of sandwich-type biosensors utilizing DET is challenged by the scarcity of aptamer-aptamer sandwich pairs with high affinity in complex biological samples. Here, we introduce an electrochemical biosensor using an antibody-aptamer hybrid sandwich for detect...
Source: Biosensors and Bioelectronics - March 7, 2024 Category: Biotechnology Authors: Gyeongho Kim Haesik Yang Source Type: research
A novel fluorescent aptasensor for sensitive and selective detection of environmental toxins fumonisin B1 based on enzyme-assisted dual recycling amplification and 2D δ-FeOOH-NH < sub > 2 < /sub > nanosheets
This study not only provides novel insights into the development of fluorescence biosensors based on 2D nanomaterials combined with CRISPR/Cas12a, but also exhibits remarkable applicability in detecting other significant targets.PMID:38452570 | DOI:10.1016/j.bios.2024.116183 (Source: Biosensors and Bioelectronics)
Source: Biosensors and Bioelectronics - March 7, 2024 Category: Biotechnology Authors: Xiang Li Yunxiao Ma Mengyuan He Bing Tan Gongke Wang Guifen Zhu Source Type: research
SWCNTs/PEDOT:PSS nanocomposites-modified microelectrode arrays for revealing locking relations between burst and local field potential in cultured cortical networks
This study not only highlighted the pivotal role of SWCNTs/PEDOT:PSS-modified MEAs in elucidating the interaction between burst and LFP, bridging the gap between slow and fast brain rhythms in vitro but also provides valuable insights into the potential therapeutic strategies targeting neurological disorders associated with abnormal rhythm generation.PMID:38452571 | DOI:10.1016/j.bios.2024.116168 (Source: Biosensors and Bioelectronics)
Source: Biosensors and Bioelectronics - March 7, 2024 Category: Biotechnology Authors: Yaoyao Liu Shihong Xu Yu Deng Jinping Luo Kui Zhang Yan Yang Longze Sha Ruilin Hu Zhaojie Xu Erwei Yin Qi Xu Yirong Wu Xinxia Cai Source Type: research
Cascade reaction triggered colorimetric array for identification of organophosphorus pesticides congeners
Biosens Bioelectron. 2024 Feb 24;253:116143. doi: 10.1016/j.bios.2024.116143. Online ahead of print.ABSTRACTA modern agriculture uses alternative pest control methods to boost productivity, leading to an accumulation of organophosphorus (OPPs) congeners. This necessitates an intuitive and quick way to identify OPPs congeners. A colorimetric sensor for detecting OPPs congeners using a double-enzyme cascade reaction has been successfully designed and constructed in this study. The OPPs regulate the color changes induced by manganese dioxide nanoflowers (MnO2 NFs) and specific alkaline phosphatases (ALP) during the etching of...
Source: Biosensors and Bioelectronics - March 7, 2024 Category: Biotechnology Authors: Zikang Chen Ming Li Weiwei Chen Jingyi Zhou Xungang Gu Caiping Ding Youju Huang Source Type: research
Multifunctional self-priming hairpin probe-based isothermal nucleic acid amplification and its applications for COVID-19 diagnosis
Biosens Bioelectron. 2024 Feb 20;253:116147. doi: 10.1016/j.bios.2024.116147. Online ahead of print.ABSTRACTWe herein present a multifunctional self-priming hairpin probe-based isothermal amplification, termed MSH, enabling one-pot detection of target nucleic acids. The sophisticatedly designed multifunctional self-priming hairpin (MSH) probe recognizes the target and rearranges to prime itself, triggering the amplification reaction powered by the continuously repeated extension, nicking, and target recycling. As a consequence, a large number of double-stranded DNA (dsDNA) amplicons are produced that could be monitored in ...
Source: Biosensors and Bioelectronics - March 7, 2024 Category: Biotechnology Authors: Hansol Kim Seoyoung Lee Yong Ju Hyoyong Kim Hyowon Jang Yeonkyung Park Sang Mo Lee Dongeun Yong Taejoon Kang Hyun Gyu Park Source Type: research
Electrochemical biosensor using direct electron transfer and an antibody-aptamer hybrid sandwich for target detection in complex biological samples
Biosens Bioelectron. 2024 Mar 3;253:116184. doi: 10.1016/j.bios.2024.116184. Online ahead of print.ABSTRACTDirect electron transfer (DET) between an electrode and redox labels is feasible in electrochemical biosensors using small aptamer-aptamer sandwiches; however, its application is limited in biosensors that rely on larger antibody-antibody sandwiches. The development of sandwich-type biosensors utilizing DET is challenged by the scarcity of aptamer-aptamer sandwich pairs with high affinity in complex biological samples. Here, we introduce an electrochemical biosensor using an antibody-aptamer hybrid sandwich for detect...
Source: Biosensors and Bioelectronics - March 7, 2024 Category: Biotechnology Authors: Gyeongho Kim Haesik Yang Source Type: research
A novel fluorescent aptasensor for sensitive and selective detection of environmental toxins fumonisin B1 based on enzyme-assisted dual recycling amplification and 2D δ-FeOOH-NH < sub > 2 < /sub > nanosheets
This study not only provides novel insights into the development of fluorescence biosensors based on 2D nanomaterials combined with CRISPR/Cas12a, but also exhibits remarkable applicability in detecting other significant targets.PMID:38452570 | DOI:10.1016/j.bios.2024.116183 (Source: Biosensors and Bioelectronics)
Source: Biosensors and Bioelectronics - March 7, 2024 Category: Biotechnology Authors: Xiang Li Yunxiao Ma Mengyuan He Bing Tan Gongke Wang Guifen Zhu Source Type: research
SWCNTs/PEDOT:PSS nanocomposites-modified microelectrode arrays for revealing locking relations between burst and local field potential in cultured cortical networks
This study not only highlighted the pivotal role of SWCNTs/PEDOT:PSS-modified MEAs in elucidating the interaction between burst and LFP, bridging the gap between slow and fast brain rhythms in vitro but also provides valuable insights into the potential therapeutic strategies targeting neurological disorders associated with abnormal rhythm generation.PMID:38452571 | DOI:10.1016/j.bios.2024.116168 (Source: Biosensors and Bioelectronics)
Source: Biosensors and Bioelectronics - March 7, 2024 Category: Biotechnology Authors: Yaoyao Liu Shihong Xu Yu Deng Jinping Luo Kui Zhang Yan Yang Longze Sha Ruilin Hu Zhaojie Xu Erwei Yin Qi Xu Yirong Wu Xinxia Cai Source Type: research
A triple read-out visible biosensing platform based on multifunctional nanozyme and bipolar electrode for multi-mode detection and imaging of CEA
Biosens Bioelectron. 2024 Feb 28;253:116170. doi: 10.1016/j.bios.2024.116170. Online ahead of print.ABSTRACTIn this paper, a proposal of closed bipolar electrode (BPE) and nanozyme based multi-mode biosensing platform is first presented. As a novel integrated chip, multi-mode-BPE (MMBPE) combines enzyme-linked immunoassay (ELISA), electrochemiluminescence (ECL), ECL imaging and light emitting diode (LED) imaging, enabling highly sensitive triple read-out visible detection of cancer embryonic antigen (CEA). The ECL probe Ab2@Au@Co3O4/CoFe2O4 hollow nanocubes (HNCs) with excellent peroxidase (POD) activity is introduced into...
Source: Biosensors and Bioelectronics - March 5, 2024 Category: Biotechnology Authors: Shumin Wang Xinyue Li Xinli Wang Xiaodi Wu Degang Jiang Hong Zhou Shunxiang Gao Jing Liu Source Type: research
Highly selective nanozyme-based glucose sensing platform via construction of artificial recognition sites on gold nanospheres
Biosens Bioelectron. 2024 Feb 28;253:116169. doi: 10.1016/j.bios.2024.116169. Online ahead of print.ABSTRACTNanozymes have been regarded as the ideal alternatives to natural enzymes in bioassays due to their good stability and low cost. However, their applications in sensing usually suffer from poor selectivity. For example, Au-based nanozymes, as a kind of classical glucose oxidase mimic enzyme, could catalyze diverse monosaccharides. Therefore, it is of great necessity and urgency to endow the Au-based nanozymes with enhanced selectivity for the construction of specific glucose sensing platform. In our study, easily recy...
Source: Biosensors and Bioelectronics - March 5, 2024 Category: Biotechnology Authors: Jinping Yu Tao Chen Xueyun Wen Hao Shi Lupeng Wang Yuanhong Xu Source Type: research
A triple read-out visible biosensing platform based on multifunctional nanozyme and bipolar electrode for multi-mode detection and imaging of CEA
Biosens Bioelectron. 2024 Feb 28;253:116170. doi: 10.1016/j.bios.2024.116170. Online ahead of print.ABSTRACTIn this paper, a proposal of closed bipolar electrode (BPE) and nanozyme based multi-mode biosensing platform is first presented. As a novel integrated chip, multi-mode-BPE (MMBPE) combines enzyme-linked immunoassay (ELISA), electrochemiluminescence (ECL), ECL imaging and light emitting diode (LED) imaging, enabling highly sensitive triple read-out visible detection of cancer embryonic antigen (CEA). The ECL probe Ab2@Au@Co3O4/CoFe2O4 hollow nanocubes (HNCs) with excellent peroxidase (POD) activity is introduced into...
Source: Biosensors and Bioelectronics - March 5, 2024 Category: Biotechnology Authors: Shumin Wang Xinyue Li Xinli Wang Xiaodi Wu Degang Jiang Hong Zhou Shunxiang Gao Jing Liu Source Type: research
Highly selective nanozyme-based glucose sensing platform via construction of artificial recognition sites on gold nanospheres
Biosens Bioelectron. 2024 Feb 28;253:116169. doi: 10.1016/j.bios.2024.116169. Online ahead of print.ABSTRACTNanozymes have been regarded as the ideal alternatives to natural enzymes in bioassays due to their good stability and low cost. However, their applications in sensing usually suffer from poor selectivity. For example, Au-based nanozymes, as a kind of classical glucose oxidase mimic enzyme, could catalyze diverse monosaccharides. Therefore, it is of great necessity and urgency to endow the Au-based nanozymes with enhanced selectivity for the construction of specific glucose sensing platform. In our study, easily recy...
Source: Biosensors and Bioelectronics - March 5, 2024 Category: Biotechnology Authors: Jinping Yu Tao Chen Xueyun Wen Hao Shi Lupeng Wang Yuanhong Xu Source Type: research
