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Total 310 results found since Jan 2013.

Machine learning studies on major brain diseases: 5-year trends of 2014 –2018
AbstractIn the recent 5  years (2014–2018), there has been growing interest in the use of machine learning (ML) techniques to explore image diagnosis and prognosis of therapeutic lesion changes within the area of neuroradiology. However, to date, the majority of research trend and current status have not been clearly il luminated in the neuroradiology field. More than 1000 papers have been published during the past 5 years on subject classification and prediction focused on multiple brain disorders. We provide a survey of 209 papers in this field with a focus on top ten active areas of research; i.e., Alzheimer’ s di...
Source: Japanese Journal of Radiology - November 29, 2018 Category: Radiology Source Type: research

Resistant and refractory hypertension: two sides of the same disease?
In conclusion, both RH and RfH constitute challenges in clinical practice and should be addressed as distinct clinical entities by trained professionals who are capable to identify comorbidities and provide specific, diversified, and individualized treatment. PMID: 30525180 [PubMed - as supplied by publisher]
Source: Jornal Brasileiro de Nefrologia - December 15, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Influence of Platelet Aggregate Formation in Blood Samples on Light Transmission Aggregometry Results
This study aimed to evaluate the effects of platelet aggregate formation on light transmission aggregometry results.
Source: Journal of Stroke and Cerebrovascular Diseases - January 7, 2019 Category: Neurology Authors: Eriko Sugawara, Mie Shimizu, Masahiro Yamamoto, Yosuke Kudo, Fumiaki Tanaka, Ken Johkura Source Type: research

Heat stress combined with lipopolysaccharide alter the activity and superficial molecules of peripheral monocytes.
The objectives were divided into four groups: 43°C heat stress combined with lipopolysaccharide (LPS) group, 43°C heat stress group, LPS group, and control group. There were 10 cases in each group. An enzyme-linked immunosorbent assay (ELISA) test was used to measure the concentrations of supernatant inflammatory mediators (tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β) and interleukin-10 (IL-10)). After loaded by 2,7-Dichlorodi-hydrofluorescein-diacetate (DCFHDA) fluorescent probe, intracellular reactive oxygen species (ROS) levels were determined by a flow cytometry. After fluorescent microspheres incub...
Source: International Journal of Immunopathology and Pharmacology - February 17, 2019 Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research

Oral Cannabidiol Prevents Allodynia and Neurological Dysfunctions in a Mouse Model of Mild Traumatic Brain Injury
Conclusion In conclusion, our data demonstrate that mTBI causes late sensorial affective/cognitive deficiencies linked to altered neurotransmitter release at cortical level. Moreover, we showed that chronic CBD treatment reduces behavioral dysfunctions by restoring at least in part cortical biochemical processes. Taken together, our results suggest that CBD could represent a novel approach for the management of neuropsychiatric disorders associated with TBI. Author Contributions CB, LL, and RR conceived and designed the experiments. CB, MI, SB, FR, RI, and RM performed the experiments. GP, LS, SP, RR, LL, and IM analyze...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

The incremental value of neuropsychological assessment: a critical review.
CONCLUSIONS: Neuropsychological assessment can improve both diagnostic classification and prediction of long-term daily-life outcomes in patients across the lifespan. Future high-quality prospective cohort studies and randomized-controlled trials are necessary to demonstrate more definitively the incremental value of neuropsychological assessment in the management of patients with various neurological and other medical conditions. PMID: 31014166 [PubMed - as supplied by publisher]
Source: The Clinical Neuropsychologist - April 22, 2019 Category: Psychiatry & Psychology Authors: Donders J Tags: Clin Neuropsychol Source Type: research

Longitudinal Academic Outcomes of Children with Secondary Attention Deficit/Hyperactivity Disorder following Pediatric Stroke
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Source: Developmental Neuropsychology - May 8, 2019 Category: Neurology Authors: Samantha D. Roberts Kyla P. McDonald Ashley Danguecan Jennifer Crosbie Robyn Westmacott Brendan Andrade Nomazulu Dlamini Tricia S. Williams Source Type: research

Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms
This article also addresses the neuropharmacological potential of taurine analogs.Graphical abstract
Source: Redox Biology - May 22, 2019 Category: Biology Source Type: research

Consensus Paper: Experimental Neurostimulation of the Cerebellum
We report on the most advanced techniques for manipulating cerebellar circuits in humans and animal models and define key hurdles and questions for moving forward.
Source: The Cerebellum - June 3, 2019 Category: Neurology Source Type: research

Consensus Paper: Experimental Neurostimulation of the Cerebellum.
We report on the most advanced techniques for manipulating cerebellar circuits in humans and animal models and define key hurdles and questions for moving forward. PMID: 31165428 [PubMed - as supplied by publisher]
Source: Cerebellum - June 3, 2019 Category: Neuroscience Authors: Miterko LN, Baker KB, Beckinghausen J, Bradnam LV, Cheng MY, Cooperrider J, DeLong MR, Gornati SV, Hallett M, Heck DH, Hoebeek FE, Kouzani AZ, Kuo SH, Louis ED, Machado A, Manto M, McCambridge AB, Nitsche MA, Taib NOB, Popa T, Tanaka M, Timmann D, Steinbe Tags: Cerebellum Source Type: research

Cholinergic nervous system and glaucoma: From basic science to clinical applications
Publication date: Available online 23 June 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Muneeb A. Faiq, Gadi Wollstein, Joel S. Schuman, Kevin C. ChanAbstractThe cholinergic system has a crucial role to play in visual function. Although cholinergic drugs have been a focus of attention as glaucoma medications for reducing eye pressure, little is known about the potential modality for neuronal survival and/or enhancement in visual impairments. Citicoline, a naturally occurring compound and FDA approved dietary supplement, is a nootropic agent that is recently demonstrated to be effective in ameliorating ischemi...
Source: Progress in Retinal and Eye Research - June 25, 2019 Category: Opthalmology Source Type: research

Modulators of platelet function in aging.
Authors: Iyer KS, Dayal S Abstract Platelets are small, anucleated effector cells that play an important role in linking the hemostatic and inflammatory processes in the body. Platelet function is known to be altered under various inflammatory conditions including aging. A gain in platelet function during aging can increase the risk of thrombotic events, such as stroke and acute myocardial infarction. Anti-platelet therapy is designed to reduce risk of serious cerebrovascular and cardiovascular events, but the adverse consequences of therapy, such as risk for bleeding increases with aging as well. Age-associated co...
Source: Platelets - September 18, 2019 Category: Hematology Tags: Platelets Source Type: research

Application of functional near-infrared spectroscopy in the healthcare industry: A review
This study comprehensively reviews brain-impaired patients: The studies involving patient populations and the diseases discussed in more than 10 works are included. Eleven diseases examined in this paper include autism spectrum disorder, attention-deficit hyperactivity disorder, epilepsy, depressive disorders, anxiety and panic disorder, schizophrenia, mild cognitive impairment, Alzheimer ’s disease, Parkinson’s disease, stroke, and traumatic brain injury. For each disease, the tasks used for examination, fNIRS variables, and significant findings on the impairment are discussed. The channel configurations and the regio...
Source: Journal of Innovative Optical Health Sciences - September 11, 2019 Category: Biomedical Science Authors: Keum-Shik Hong M. Atif Yaqub Source Type: research

A Novel Model of Mixed Vascular Dementia Incorporating Hypertension in a Rat Model of Alzheimer ’s Disease
Alzheimer’s disease (AD) and mixed dementia (MxD) comprise the majority of dementia cases in the growing global aging population. MxD describes the coexistence of AD pathology with vascular pathology, including cerebral small vessel disease (SVD). Cardiovascular disease increases risk for AD and MxD, but mechanistic synergisms between the coexisting pathologies affecting dementia risk, progression and the ultimate clinical manifestations remain elusive. To explore the additive or synergistic interactions between AD and chronic hypertension, we developed a rat model of MxD, produced by breeding APPswe/PS1ΔE9 transgenes i...
Source: Frontiers in Physiology - October 23, 2019 Category: Physiology Source Type: research