Machine learning studies on major brain diseases: 5-year trends of 2014 –2018

AbstractIn the recent 5  years (2014–2018), there has been growing interest in the use of machine learning (ML) techniques to explore image diagnosis and prognosis of therapeutic lesion changes within the area of neuroradiology. However, to date, the majority of research trend and current status have not been clearly il luminated in the neuroradiology field. More than 1000 papers have been published during the past 5 years on subject classification and prediction focused on multiple brain disorders. We provide a survey of 209 papers in this field with a focus on top ten active areas of research; i.e., Alzheimer’ s disease/mild cognitive impairment, brain tumor; schizophrenia, depressive disorders, Parkinson’s disease, attention-deficit hyperactivity disorder, autism spectrum disease, epilepsy, multiple sclerosis, stroke, and traumatic brain injury. Detailed information of these studies, such as ML methods , sample size, type of inputted features and reported accuracy, are summarized. This paper reviews the evidences, current limitations and status of studies using ML to assess brain disorders in neuroimaging data. The main bottleneck of this research field is still the limited sample size, which coul d be potentially addressed by modern data sharing models, such as ADNI.
Source: Japanese Journal of Radiology - Category: Radiology Source Type: research

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Publication date: June 2019Source: Research in Developmental Disabilities, Volume 89Author(s): Abigail M.A. Love, Michael D. Toland, Ellen L. Usher, Jonathan M. Campbell, Amy D. SpriggsAbstractCurrently, 1 in 68 children in the U.S. is diagnosed with Autism Spectrum Disorder (ASD; Centers for Disease Control &Prevention, 2015) and this growing population of learners has been noted as one of the most challenging groups to teach. Teacher self-efficacy, the belief teachers hold about their instructional capabilities, has been shown to differ according to contextual factors, such as the type of students teachers face. The ...
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
CONCLUSIONS: CCBT with a modest amount of support from a clinician or other helping person was found to be efficacious with relatively large mean effect sizes on measures of depressive symptoms. Self-guided CCBT for depression was considerably less effective. Future research should focus on enhancing the implementation of CCBT, including evaluating the amount and type of support needed for effective delivery, methods to improve engagement with computer-assisted therapies, and ways to improve treatment outcome in primary care settings. PMID: 30900849 [PubMed - in process]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Authors: Faden J PMID: 30900848 [PubMed - in process]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Publication date: Available online 23 March 2019Source: Life SciencesAuthor(s): Elizabeta Zaplatic, Muhammed Bule, Syed Zahid Ali Shah, Md. Sahab Uddin, Kamal NiazAbstractQuercetin belongs to the flavonoids family, which is present in most of the plants including fruits, vegetables, green tea and even in red wine having antioxidant activities. It is available as a food supplement in the market and has physiological health effects. Quercetin has anti-inflammatory, anticancer and anti-prostate activities along with its beneficial effects on high cholesterol, kidney transplantation, asthma, diabetes, viral infections, pulmona...
Source: Life Sciences - Category: Biology Source Type: research
In this study, we examined the biological activity and the immunomodulatory property of a GCSF homologue, PoGCSF, from Japanese flounder (Paralichthys olivaceus). Structural analysis showed that PoGCSF possesses conserved structural characteristics of GCSF proteins, including a signal peptide and a typical IL-6 domain. The expression of PoGCSF was upregulated in a time-dependent manner by extracellular and intracellular bacterial pathogens and viral pathogen. Different expression patterns were exhibited in response to the infection of different types of microbial pathogens in different immune tissues. Recombinant PoGCSF in...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
In this study, we characterized the grouper KLF9 gene (EcKLF9) and investigated its role in viral infection. Amino acid alignment analysis showed that EcKLF9 was approximately 228 amino acids long and contained a typical three-tandem Krϋppel-like zinc fingers. Phylogenetic tree analysis revealed that EcKLF9 clustered with three fish species: Amphiprion ocellaris, Acanthochromis pollyacanthus and Stegastes partitus. Comparison analyses showed that the three Kruppel-like zinc finger domains of KLF9 were highly conserved in different fish species. Tissue expression analysis showed that EcKLF9 was constitutively expressed in ...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
ConclusionOur findings highlight the potential value of WES to identify heritable risk factors that could affect the reabsorption of transferrin-bound iron in the kidneys causing sustained iron loss, together with inhibition of vitamin B12 absorption and vitamin D reabsorption (CUBN) and iron transport into mitochondria (SLC25A37) as the sole site of heme synthesis. This supports a model for RRMS in children with an apparent iron-deficient biochemical subtype of MS, with oligodendrocyte cell death and impaired myelination possibly caused by deficits of energy- and antioxidant capacity in mitochondria.
Source: Molecular Genetics and Metabolism Reports - Category: Genetics & Stem Cells Source Type: research
We examined the role of rejection of care, aggression and agitation to caregiver depression and if social support and mastery inde...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
BACKGROUND: The rates of suicide increase with age and reach their highest levels in the oldest age groupings and are sufficiently large for them to constitute a public health concern. The number of deaths due to suicides after the age of 60 years in Italy...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
INTRODUCTION AND OBJECTIVES: Elderly patients with diabetes have been shown to have more diabetes-related complications, and they are more likely to develop somatic and psychiatric comorbidities including cognitive dysfunction and depression. Several studi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
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