The Cell Biology of the Retinal Pigment Epithelium
Publication date: Available online 24 February 2020Source: Progress in Retinal and Eye ResearchAuthor(s): Aparna Lakkaraju, Ankita Umapathy, Li Xuan Tan, Lauren Daniele, Nancy J. Philp, Kathleen Boesze-Battaglia, David S. Williams (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - February 25, 2020 Category: Opthalmology Source Type: research

No flow through the vitreous humor: how strong is the evidence?
Publication date: Available online 6 February 2020Source: Progress in Retinal and Eye ResearchAuthor(s): David W. Smith, Chang-Joon Lee, Bruce S. GardinerAbstractWhen analyzing vitreal drug delivery, or the pharmacological effects of drugs on intraocular pressure, or when interpreting outflow facility measurements, it is generally accepted that the fluid in the vitreous humor is stagnant. It is accepted that for all practical purposes, the aqueous fluid exits the eye via anterior pathways only, and so there is negligible if any posteriorly directed flow of aqueous through the vitreous humor. This assumption is largely base...
Source: Progress in Retinal and Eye Research - February 6, 2020 Category: Opthalmology Source Type: research

Cell types and cell circuits in primate retina
Publication date: Available online 5 February 2020Source: Progress in Retinal and Eye ResearchAuthor(s): Ulrike Grünert, Paul R. MartinAbstractThis review summarises our current knowledge of primate including human retina focusing on bipolar, amacrine and ganglion cells and their connectivity. We have two main motivations in writing. Firstly, recent progress in non-invasive imaging methods to study retinal diseases mean that better understanding of the primate retina is becoming an important goal both for basic and for clinical sciences. Secondly, genetically modified mice are increasingly used as animal models for hu...
Source: Progress in Retinal and Eye Research - February 5, 2020 Category: Opthalmology Source Type: research

Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies
Publication date: Available online 29 January 2020Source: Progress in Retinal and Eye ResearchAuthor(s): Nadia Sukusu Nielsen, Ebbe Toftgaard Poulsen, Marie V. Lukassen, Connie Chao Shern, Emilie Hage Mogensen, Christian E. Weberskov, Larry DeDionisio, Leif Schauser, Tara C.B. Moore, Daniel E. Otzen, Jesper Hjortdal, Jan J. EnghildAbstractTransforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the second most abundant protein in the corneal stroma. In this review, we summarize the current knowledge concerning the expression, molecular structure, binding partners, and functions of hum...
Source: Progress in Retinal and Eye Research - January 30, 2020 Category: Opthalmology Source Type: research

Advances in the diagnosis and treatment of dry eye
Publication date: Available online 29 January 2020Source: Progress in Retinal and Eye ResearchAuthor(s): Takashi Kojima, Murat Dogru, Motoko Kawashima, Shigeru Nakamura, Kazuo TsubotaAbstractThe core mechanism of dry eye is the tear film instability. Tear film-oriented diagnosis (TFOD) is a concept to clarify the cause of tear film instability by tear film, and tear film-oriented treatment (TFOT) is a concept to treat dry eye disease by replacing the lacking components of the tear film layer based on the TFOD. In TFOD, the fluorescein breakup pattern of the tear film is important, and the subtype of dry eye can be judged t...
Source: Progress in Retinal and Eye Research - January 30, 2020 Category: Opthalmology Source Type: research

Ocular blood flow as a clinical observation: value, limitations and data analysis
This article reviews the state of the art and major unanswered questions related to ocular vascular anatomy and physiology, ocular imaging techniques, clinical findings in glaucoma and other eye diseases, and mechanistic modeling predictions, while laying a path for integrating clinical observations with mathematical models and artificial intelligence. Viable alternatives for integrated data analysis are proposed that aim to overcome the limitations of standard statistical approaches and enable individually tailored precision medicine in ophthalmology. (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - January 25, 2020 Category: Opthalmology Source Type: research

Editorial Board
Publication date: January 2020Source: Progress in Retinal and Eye Research, Volume 74Author(s): (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - January 25, 2020 Category: Opthalmology Source Type: research

A neuroglia-based interpretation of glaucomatous neuroretinal rim thinning in the optic nerve head
Publication date: Available online 23 January 2020Source: Progress in Retinal and Eye ResearchAuthor(s): Eun Jung Lee, Jong Chul Han, Do Young Park, Changwon KeeAbstractNeuroretinal rim thinning (NRR) is a characteristic glaucomatous optic disc change. However, the precise mechanism of the rim thinning has not been completely elucidated. This review focuses on the structural role of the glioarchitecture in the formation of the glaucomatous NRR thinning. The NRR is a glia-framed structure, with honeycomb geometry and mechanically reinforced astrocyte processes along the transverse plane. When neural damage selectively invol...
Source: Progress in Retinal and Eye Research - January 24, 2020 Category: Opthalmology Source Type: research

Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index
Publication date: Available online 10 January 2020Source: Progress in Retinal and Eye ResearchAuthor(s): Rupesh Agrawal, Jianbin Ding, Parveen Sen, Andres Rousselot, Amy Chan, Lisa Nivison-Smith, Xin Wei, Sarakshi Mahajan, Ramasamy Kim, Chitaranjan Mishra, Manisha Agarwal, Min Hee Suh, Saurabh Luthra, Marion R. Munk, Carol Y. Cheung, Vishali Gupta, CVI.gridAbstractThe choroid is one of the most vascularized structures of the human body and plays an irreplaceable role in nourishing photoreceptors. As such, choroidal dysfunction is implicated in a multitude of ocular diseases. Studying the choroid can lead to a better unders...
Source: Progress in Retinal and Eye Research - January 10, 2020 Category: Opthalmology Source Type: research

Interpretation of OCT and OCTA images from a histological approach: clinical and experimental implications.
Publication date: Available online 3 January 2020Source: Progress in Retinal and Eye ResearchAuthor(s): Nicolás Cuenca, Isabel Ortuño-Lizarán, Xavier Sánchez-Sáez, Oksana Kutsyr, Henar Albertos-Arranz, Laura Fernández-Sánchez, Natalia Martínez-Gil, Agustina Noailles, José Antonio López-Garrido, Maribel López-Gálvez, Pedro Lax, Victoria Maneu, Isabel PinillaAbstract:Optical coherence tomography (OCT) and OCT angiography (OCTA) have been a technological breakthrough in the diagnosis, treatment, and follow-up of many retinal diseases, thanks t...
Source: Progress in Retinal and Eye Research - January 4, 2020 Category: Opthalmology Source Type: research

Age-related macular degeneration: A two-level model hypothesis
Publication date: Available online 30 December 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Maarten P. Rozing, Jon A. Durhuus, Marie Krogh Nielsen, Yousif Subhi, Thomas BL. Kirkwood, Rudi GJ. Westendorp, Torben Lykke SørensenAbstractAge-related diseases, including age-related macular degeneration (AMD), are of growing importance in a world where population ageing has become a dominant global trend. Although a wide variety of risk factors for AMD have been identified, age itself remains by far the most important risk factor, making it an urgent priority to understand the connections between underlying a...
Source: Progress in Retinal and Eye Research - December 31, 2019 Category: Opthalmology Source Type: research

Progress in treating inherited retinal diseases: Early subretinal gene therapy clinical trials and candidates for future initiatives
Publication date: Available online 30 December 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Alexandra V. Garafalo, Artur V. Cideciyan, Elise Heon, Rebecca Sheplock, Alexander Pearson, Caberry WeiYang Yu, Alexander Sumaroka, Gustavo D. Aguirre, Samuel G. JacobsonAbstractDue to improved phenotyping and genetic characterization, the field of ‘incurable’ and ‘blinding’ inherited retinal diseases (IRDs) has moved substantially forward. Decades of ascertainment of IRD patient data from Philadelphia and Toronto centers illustrate the progress from Mendelian genetic types to molecular diagnose...
Source: Progress in Retinal and Eye Research - December 30, 2019 Category: Opthalmology Source Type: research

Mystery Eye: Human Adenovirus and the Enigma of Epidemic Keratoconjunctivitis
Publication date: Available online 28 December 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Rahul A. Jonas, Lawson Ung, Jaya Rajaiya, James ChodoshAbstractKnown to occur in widespread outbreaks, epidemic keratoconjunctivitis (EKC) is a severe ocular surface infection with a strong historical association with human adenovirus (HAdV). While the conjunctival manifestations can vary from mild follicular conjunctivitis to hyper-acute, exudative conjunctivitis with formation of conjunctival membranes, EKC is distinct as the only form of adenovirus conjunctivitis in which the cornea is also involved, likely due to s...
Source: Progress in Retinal and Eye Research - December 30, 2019 Category: Opthalmology Source Type: research

Recapitulating developmental mechanisms for retinal regeneration
Publication date: Available online 14 December 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Iqbal Ahmad, Pooja Teotia, Helen Erickson, Xiaohuan XiaAbstractDegeneration of specific retinal neurons in diseases like glaucoma, age-related macular degeneration, and retinitis pigmentosa is the leading cause of irreversible blindness. Currently, there is no therapy to modify the disease-associated degenerative changes. With the advancement in our knowledge about the mechanisms that regulate the development of the vertebrate retina, the approach to treat blinding diseases through regenerative medicine appears a near ...
Source: Progress in Retinal and Eye Research - December 14, 2019 Category: Opthalmology Source Type: research

Editorial Board
Publication date: November 2019Source: Progress in Retinal and Eye Research, Volume 73Author(s): (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - December 3, 2019 Category: Opthalmology Source Type: research

Evolution of the genes mediating phototransduction in rod and cone photoreceptors
Publication date: Available online 29 November 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Trevor D. LambAbstractThis paper reviews current knowledge of the evolution of the multiple genes encoding proteins that mediate the process of phototransduction in rod and cone photoreceptors of vertebrates. The approach primarily involves molecular phylogenetic analysis of phototransduction protein sequences, combined with analysis of the syntenic arrangement of the genes. At least 35 of these phototransduction genes appear to reside on no more than five paralogons – paralogous regions that each arose from a co...
Source: Progress in Retinal and Eye Research - November 30, 2019 Category: Opthalmology Source Type: research

Contact lens-related corneal infection: Intrinsic resistance and its compromise
Publication date: Available online 20 November 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Suzanne M.J. Fleiszig, Abby R. Kroken, Vincent Nieto, Melinda R. Grosser, Stephanie J. Wan, Matteo M.E. Metruccio, David J. EvansAbstractContact lenses represent a widely utilized form of vision correction with more than 140 million wearers worldwide. Although generally well-tolerated, contact lenses can cause corneal infection (microbial keratitis), with an approximate annualized incidence ranging from ∼2 to ∼20 cases per 10,000 wearers, and sometimes resulting in permanent vision loss. Research suggests that ...
Source: Progress in Retinal and Eye Research - November 20, 2019 Category: Opthalmology Source Type: research

Interactions of the choroid, Bruch's membrane, retinal pigment epithelium, and neurosensory retina collaborate to form the outer blood-retinal-barrier
Publication date: Available online 5 November 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Mark A. Fields, Lucian V. Del Priore, Ron A. Adelman, Lawrence J. RizzoloAbstractThe three interacting components of the outer blood-retinal barrier are the retinal pigment epithelium (RPE), choriocapillaris, and Bruch's membrane, the extracellular matrix that lies between them. Although previously reviewed independently, this review integrates these components into a more wholistic view of the barrier and discusses reconstitution models to explore the interactions among them. After updating our understanding of each co...
Source: Progress in Retinal and Eye Research - November 16, 2019 Category: Opthalmology Source Type: research

Interactions of the choroid, Bruch’s membrane, retinal pigment epithelium, and neurosensory retina collaborate to form the outer blood-retinal-barrier
Publication date: Available online 5 November 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Mark Fields, Lucian V. Del Priore, Ron A. Adelman, Lawrence J. RizzoloAbstractThe three interacting components of the outer blood-retinal barrier are the retinal pigment epithelium (RPE), choriocapillaris, and Bruch’s membrane, the extracellular matrix that lies between them. Although previously reviewed independently, this review integrates these components into a more wholistic view of the barrier and discusses reconstitution models to explore the interactions among them. After updating our understanding of each...
Source: Progress in Retinal and Eye Research - November 6, 2019 Category: Opthalmology Source Type: research

Spatiotemporal changes in the human lens proteome: critical insights into long-lived proteins
Publication date: Available online 6 November 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Kevin L. Schey, Zhen Wang, Michael Friedrich, Donita L. Garland, Roger J.W. TruscottAbstractThe ocular lens is a unique tissue that contains an age gradient of cells and proteins ranging from newly differentiated cells containing newly synthesized proteins to cells and proteins that are as old as the organism. Thus, the ocular lens is an excellent model for studying long-lived proteins (LLPs) and the effects of aging and post-translational modifications on protein structure and function. Given the architecture of the le...
Source: Progress in Retinal and Eye Research - November 6, 2019 Category: Opthalmology Source Type: research

Beyond Intraocular Pressure: Optimizing Patient-Reported Outcomes In Glaucoma
Publication date: Available online 31 October 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Eva Fenwick, Ryan Man, Tin Aung, Pradeep Ramulu, Ecosse LamoureuxAbstractGlaucoma, an irreversible blinding condition affecting 3-4% adults aged above 40 years worldwide, is set to increase with a rapidly aging global population. Raised intraocular pressure (IOP) is a major risk factor for glaucoma where the treatment paradigm is focused on managing IOP using medications, laser, or surgery regimens. However, notwithstanding IOP and other clinical parameters, patient-reported outcomes, including daily functioning, emotio...
Source: Progress in Retinal and Eye Research - November 1, 2019 Category: Opthalmology Source Type: research

Uveal melanoma: towards a molecular understanding
Publication date: Available online 26 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Kyra N. Smit, Martine J. Jager, Annelies de Klein, Emine KiliҫAbstractUveal melanoma is an aggressive malignancy that originates from melanocytes in the eye. Even if the primary tumor has been successfully treated with radiation or surgery, up to half of all UM patients will eventually develop metastatic disease. Despite the common origin from neural crest-derived cells, uveal and cutaneous melanoma have few overlapping genetic signatures and uveal melanoma has been shown to have a lower mutational burden. As a conse...
Source: Progress in Retinal and Eye Research - September 28, 2019 Category: Opthalmology Source Type: research

Melatonin and the control of intraocular pressure
Publication date: Available online 25 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Hanan Awad Alkozi, Gemma Navarro, Rafael Franco, Jesus Pintor (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - September 25, 2019 Category: Opthalmology Source Type: research

Inducible Rodent Models of Glaucoma
Publication date: Available online 23 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Iok-Hou Pang, Abbot F. ClarkAbstractGlaucoma is one of the leading causes of vision impairment worldwide. In order to further understand the molecular pathobiology of this disease and to develop better therapies, clinically relevant animal models are necessary. In recent years, both the rat and mouse have become popular models in glaucoma research. Key reasons are: many important biological similarities shared among rodent eyes and the human eye; development of improved methods to induce glaucoma and to evaluate glauc...
Source: Progress in Retinal and Eye Research - September 24, 2019 Category: Opthalmology Source Type: research

Membrane-associated mucins of the ocular surface: New genes, new protein functions and new biological roles in human and mouse
Publication date: Available online 4 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): M. Elizabeth Fini, Shinwu Jeong, Haiyan Gong, Rafael Martinez-Carrasco, Nora M.V. Laver, Minako Hijikata, Naoto Keicho, Pablo ArgüesoAbstractThe mucosal glycocalyx of the ocular surface constitutes the point of interaction between the tear film and the apical epithelial cells. Membrane-associated mucins (MAMs) are the defining molecules of the glycocalyx in all mucosal epithelia. Long recognized for their biophysical properties of hydration, lubrication, anti-adhesion and repulsion, MAMs maintain the wet ocular su...
Source: Progress in Retinal and Eye Research - September 19, 2019 Category: Opthalmology Source Type: research

Editorial Board
Publication date: September 2019Source: Progress in Retinal and Eye Research, Volume 72Author(s): (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - September 11, 2019 Category: Opthalmology Source Type: research

Publisher's Note
Publication date: September 2019Source: Progress in Retinal and Eye Research, Volume 72Author(s): (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - September 11, 2019 Category: Opthalmology Source Type: research

Optical coherence tomography diagnostic signs in posterior uveitis
Publication date: Available online 9 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Francesco Pichi, Alessandro Invernizzi, William R. Tucker, Marion R. MunkAbstractA diagnostic sign refers to a quantifiable biological parameter that is measured and evaluated as an indicator of normal biological, pathogenic, or pharmacologic responses to a therapeutic intervention. When used in translational research discussions, the term itself often alludes to a signs used to accelerate or aid in diagnosis or monitoring and provide insight into “personalized” medicine. Many new diagnostic signs are being...
Source: Progress in Retinal and Eye Research - September 10, 2019 Category: Opthalmology Source Type: research

Stromal keratophakia: Corneal inlay implantation
Publication date: Available online 4 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Andri K. Riau, Yu-Chi Liu, Gary H.F. Yam, Jodhbir S. MehtaAbstractStromal keratophakia was first performed by José Ignacio Barraquer in the 1960s. The refractive lamellar keratoplasty technique was intensely pursued in the 1980s as a method to alter corneal refractive power. However, because sculpting of the donor stromal lenticule and lamellar keratectomy of the recipient's cornea were performed with a mechanical microkeratome, the quality of the cut was inconsistent. Consequently, the refractive outcomes of th...
Source: Progress in Retinal and Eye Research - September 8, 2019 Category: Opthalmology Source Type: research

Innate immune response in retinal homeostasis and inflammatory disorders
Publication date: Available online 7 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Yusuke Murakami, Keijiro Ishikawa, Shintaro Nakao, Koh-Hei SonodaAbstractInnate immune cells such as neutrophils, monocyte-macrophages and microglial cells are pivotal for the health and disease of the retina. For the maintenance of retinal homeostasis, these cells and immunosuppressive molecules in the eye actively regulate the induction and the expression of inflammation in order to prevent excessive activation and subsequent tissue damage. In the disease context, these regulatory mechanisms are modulated genetically...
Source: Progress in Retinal and Eye Research - September 8, 2019 Category: Opthalmology Source Type: research

Diurnal rodents as pertinent animal models of human retinal physiology and pathology
Publication date: Available online 6 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Daniela M. Verra, Benjamin S. Sajdak, Dana K. Merriman, David HicksAbstractThis presentation will survey the retinal architecture, advantages, and limitations of several lesser-known rodent species that provide a useful diurnal complement to rats and mice. These diurnal rodents also possess unusually cone-rich photoreceptor mosaics that facilitate the study of cone cells and pathways. Species to be presented include principally the Sudanian Unstriped Grass Rat and Nile Rat (Arvicanthis spp.), the Fat Sand Rat (Psammomy...
Source: Progress in Retinal and Eye Research - September 8, 2019 Category: Opthalmology Source Type: research

Retinal stem cell transplantation: Balancing safety and potential
Publication date: Available online 5 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Mandeep S. Singh, Susanna S. Park, Thomas A. Albini, M. Valeria Canto-Soler, Henry Klassen, Robert E. MacLaren, Masayo Takahashi, Aaron Nagiel, Steven D. Schwartz, Kapil BhartiAbstractStem cell transplantation holds great promise as a potential treatment for currently incurable retinal degenerative diseases that cause poor vision and blindness. Recently, safety data have emerged from several Phase I/II clinical trials of retinal stem cell transplantation. These clinical trials, usually run in partnership with academic ...
Source: Progress in Retinal and Eye Research - September 6, 2019 Category: Opthalmology Source Type: research

Membrane-associated mucins of the ocular surface new genes, new protein functions and new biological roles in human and mouse
Publication date: Available online 4 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): M.Elizabeth Fini, Shinwu Jeong, Haiyan Gong, Rafael Martinez-Carrasco, Nora M.V. Laver, Minako Hijikata, Naoto Keicho, Pablo ArgüesoAbstractThe mucosal glycocalyx of the ocular surface constitutes the point of interaction between the tear film and the apical epithelial cells. Membrane-associated mucins (MAMs) are the defining molecules of the glycocalyx in all mucosal epithelia. Long recognized for their biophysical properties of hydration, lubrication, anti-adhesion and repulsion, MAMs maintain the wet ocular sur...
Source: Progress in Retinal and Eye Research - September 5, 2019 Category: Opthalmology Source Type: research

Stromal keratophakia
Publication date: Available online 4 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Andri K. Riau, Yu-Chi Liu, Gary H.F. Yam, Jodhbir S. MehtaAbstractStromal keratophakia was first performed by José Ignacio Barraquer in the 1960s. The refractive lamellar keratoplasty technique was intensely pursued in the 1980s as a method to alter corneal refractive power. However, because sculpting of the donor stromal lenticule and lamellar keratectomy of the recipient's cornea were performed with a mechanical microkeratome, the quality of the cut was poor and inconsistent. Consequently, the refractive outco...
Source: Progress in Retinal and Eye Research - September 4, 2019 Category: Opthalmology Source Type: research

Understanding the complexity of the matrix metalloproteinase system and its relevance to age-related diseases: Age-related macular degeneration and Alzheimer's disease
Publication date: Available online 29 August 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Ali A. Hussain, Yunhee Lee, John MarshallAbstractExtracellular matrices (ECMs) are maintained by tightly coupled processes of continuous synthesis and degradation. The degradative arm is mediated by a family of proteolytic enzymes called the matrix metalloproteinases (MMPs). These enzymes are released as latent proteins (pro-MMPs) and on activation are capable of degrading most components of an ECM. Activity of these enzymes is checked by the presence of tissue inhibitors of MMPs (TIMPs) and current opinion holds that th...
Source: Progress in Retinal and Eye Research - August 30, 2019 Category: Opthalmology Source Type: research

Lessons learned from quantitative fundus autofluorescence
Publication date: Available online 28 August 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Janet R. Sparrow, Tobias Duncker, Kaspar Schuerch, Maarjaliis Paavo, Jose Ronaldo Lima de CarvalhoAbstractQuantitative fundus autofluorescence (qAF) is an approach that is built on a confocal scanning laser platform and used to measure the intensity of the inherent autofluorescence of retina elicited by short-wavelength (488 nm) excitation. Being non-invasive, qAF does not interrupt tissue architecture, thus allowing for structural correlations. The spectral features, cellular origin and topographic distribution of the...
Source: Progress in Retinal and Eye Research - August 29, 2019 Category: Opthalmology Source Type: research

Scleral structure and biomechanics
Publication date: Available online 11 August 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Craig Boote, Ian A. Sigal, Rafael Grytz, Yi Hua, Thao D. Nguyen, Michael J.A. GirardAbstractAs the eye's main load-bearing connective tissue, the sclera is centrally important to vision. In addition to cooperatively maintaining refractive status with the cornea, the sclera must also provide stable mechanical support to vulnerable internal ocular structures such as the retina and optic nerve head. Moreover, it must achieve this under complex, dynamic loading conditions imposed by eye movements and fluid pressures. Recent ...
Source: Progress in Retinal and Eye Research - August 13, 2019 Category: Opthalmology Source Type: research

Editorial Board
Publication date: July 2019Source: Progress in Retinal and Eye Research, Volume 71Author(s): (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - August 7, 2019 Category: Opthalmology Source Type: research

Cellular mechanisms of hereditary photoreceptor degeneration – Focus on cGMP
Publication date: Available online 30 July 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Michael Power, Soumyaparna Das, Karin Schütze, Valeria Marigo, Per Ekström, François Paquet-DurandAbstractThe cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly understood, a problem that is exacerbated by the enormous genetic heterogeneity of this disease group. However, the last decade has yielded a wealth of new knowledge on degenerative pathways and their diversity. Notably, a central role of cGMP-signalling has surfaced for photoreceptor cell death triggered by a sub...
Source: Progress in Retinal and Eye Research - August 1, 2019 Category: Opthalmology Source Type: research

Persistent remodeling and neurodegeneration in late-stage retinal degeneration
Publication date: Available online 26 July 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Rebecca L. Pfeiffer, Bryan William Jones, Robert E. MarcAbstractRetinal remodeling is a progressive series of negative plasticity revisions that arise from retinal degeneration, and are seen in retinitis pigmentosa, age-related macular degeneration and other forms of retinal disease. These processes occur regardless of the precipitating event leading to degeneration. Retinal remodeling then culminates in a late-stage neurodegeneration that is indistinguishable from progressive central nervous system (CNS) proteinopathies. ...
Source: Progress in Retinal and Eye Research - July 26, 2019 Category: Opthalmology Source Type: research

Central serous chorioretinopathy: Towards an evidence-based treatment guideline
Publication date: Available online 15 July 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Thomas J. van Rijssen, Elon H.C. van Dijk, Suzanne Yzer, Kyoko Ohno-Matsui, Jan E.E. Keunen, Reinier O. Schlingemann, Sobha Sivaprasad, Giuseppe Querques, Susan M. Downes, Sascha Fauser, Carel B. Hoyng, Felice Cardillo Piccolino, Jay K. Chhablani, Timothy Y.Y. Lai, Andrew J. Lotery, Michael Larsen, Frank G. Holz, K. Bailey Freund, Lawrence A. Yannuzzi, Camiel J.F. BoonAbstractCentral serous chorioretinopathy (CSC) is a common cause of central vision loss, primarily affecting men 20–60 years of age. To date, no consen...
Source: Progress in Retinal and Eye Research - July 17, 2019 Category: Opthalmology Source Type: research

Axon injury signaling and compartmentalized injury response in glaucoma
Publication date: Available online 10 July 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Stephanie B. Syc-Mazurek, Richard T. LibbyAbstractAxonal degeneration is an active, highly controlled process that contributes to beneficial processes, such as developmental pruning, but also to neurodegeneration. In glaucoma, ocular hypertension leads to vision loss by killing the output neurons of the retina, the retinal ganglion cells (RGC). Multiple processes have been proposed to contribute to and/or mediate axonal injury in glaucoma including: neuroinflammation, loss of neurotropic factors, dysregulation of the neuro...
Source: Progress in Retinal and Eye Research - July 10, 2019 Category: Opthalmology Source Type: research

Immune reactions after modern lamellar (DALK, DSAEK, DMEK) versus conventional penetrating corneal transplantation
Publication date: Available online 3 July 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Deniz Hos, Mario Matthaei, Felix Bock, Kazuichi Maruyama, Maria Notara, Thomas Clahsen, Yanhong Hou, Viet Nhat Hung Le, Ann-Charlott Salabarria, Jens Horstmann, Bjoern O. Bachmann, Claus CursiefenAbstractIn the past decade, novel lamellar keratoplasty techniques such as Deep Anterior Lamellar Keratoplasty (DALK) for anterior keratoplasty and Descemet stripping automated endothelial keratoplasty (DSAEK)/Descemet membrane endothelial keratoplasty (DMEK) for posterior keratoplasty have been developed. DALK eliminates the possi...
Source: Progress in Retinal and Eye Research - July 4, 2019 Category: Opthalmology Source Type: research

The transcription factor MITF in RPE function and dysfunction
Publication date: Available online 23 June 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Xiaoyin Ma, Huirong Li, Yu Chen, Juan Yang, Huaicheng Chen, Heinz Arnheiter, Ling HouAbstractDysfunction and loss of the retinal pigment epithelium (RPE) are hallmarks of retinal degenerative diseases in mammals. A critical transcription factor for RPE development and function is the microphthalmia-associated transcription factor MITF and its germline mutations are associated with clinically distinct disorders, including albinism, microphthalmia, retinal degeneration, and increased risk of developing melanoma. Many studies...
Source: Progress in Retinal and Eye Research - June 25, 2019 Category: Opthalmology Source Type: research

Cholinergic nervous system and glaucoma: From basic science to clinical applications
Publication date: Available online 23 June 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Muneeb A. Faiq, Gadi Wollstein, Joel S. Schuman, Kevin C. ChanAbstractThe cholinergic system has a crucial role to play in visual function. Although cholinergic drugs have been a focus of attention as glaucoma medications for reducing eye pressure, little is known about the potential modality for neuronal survival and/or enhancement in visual impairments. Citicoline, a naturally occurring compound and FDA approved dietary supplement, is a nootropic agent that is recently demonstrated to be effective in ameliorating ischemi...
Source: Progress in Retinal and Eye Research - June 25, 2019 Category: Opthalmology Source Type: research

Visual loss and recovery in chiasmal compression
Publication date: Available online 14 June 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Helen V. Danesh-Meyer, Jinny J. Yoon, Mitchell Lawlor, Peter J. SavinoAbstractCompression of the optic chiasm causes an optic neuropathy that may be associated with reversible visual loss often immediately following surgical decompression. While the precise pathogenesis of retinal ganglion cell impairment and eventual death remains poorly understood, a number of putative mechanisms may play a role. In this article we review the evidence supporting various stages of visual loss and recovery in chiasmal compression. These in...
Source: Progress in Retinal and Eye Research - June 14, 2019 Category: Opthalmology Source Type: research

Editorial Board
Publication date: May 2019Source: Progress in Retinal and Eye Research, Volume 70Author(s): (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - June 7, 2019 Category: Opthalmology Source Type: research

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”
Publication date: Available online 5 June 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Francis L. Munier, Maja Beck-Popovic, Guillermo L. Chantada, David Cobrinik, Tero T. Kivelä, Dietmar Lohmann, Philippe Maeder, Annette C. Moll, Angel Montero Carcaboso, Alexandre Moulin, Paula Schaiquevich, Ciara Bergin, Paul J. Dyson, Susan Houghton, Francesco Puccinelli, Yvan Vial, Marie-Claire Gaillard, Christina StathopoulosAbstractRetinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to preserve life, with ocular survival, visual preservation and quality of life as secondary a...
Source: Progress in Retinal and Eye Research - June 6, 2019 Category: Opthalmology Source Type: research

Targets of immunomodulation in bacterial endophthalmitis
Publication date: Available online 28 May 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Frederick C. Miller, Phillip S. Coburn, Mursalin Huzzatul, Austin L. LaGrow, Erin Livingston, Michelle C. CalleganAbstractBacterial infection of the posterior segment of the eye (endophthalmitis) leads to a robust host response that often results in irreversible damage to the layers of the retina, significant vision loss, and in some patients, enucleation of the globe. While a great deal of effort has gone into understanding the role of bacterial virulence factors in disease initiation and propagation, it is becoming increa...
Source: Progress in Retinal and Eye Research - May 29, 2019 Category: Opthalmology Source Type: research

Neoplasia and intraocular inflammation: From masquerade syndromes to immunotherapy-induced uveitis
Publication date: Available online 12 May 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Sara Touhami, Isabelle Audo, Céline Terrada, Alain Gaudric, Phuc LeHoang, Valérie Touitou, Bahram BodaghiAbstractMasquerade syndromes represent a large set of ophthalmological entities that mimic inflammatory conditions. Any delay in their diagnosis may be correlated with systemic dissemination or worsening of the causal disease and, therefore, with poor prognosis. One of the disadvantages of the new potent treatments of uveitis is the delay that they can induce in the diagnosis of neoplastic intraocular infil...
Source: Progress in Retinal and Eye Research - May 13, 2019 Category: Opthalmology Source Type: research