The C-Terminal Penta-Peptide Repeats of Major Royal Jelly Protein 3 Ameliorate the Progression of Inflammation in Vivo and in Vitro
Biol Pharm Bull. 2022;45(5):583-589. doi: 10.1248/bpb.b21-00922.ABSTRACTRoyal jelly (RJ) has been used as a functional foodstuff and in cosmetics for many years. RJ contains various molecules, including major royal jelly proteins (MRJPs), and affords a number of health benefits such as anti-inflammatory activity. As MRJP3 has been reported to possess anti-inflammatory properties by the in vitro analysis, we investigated the anti-inflammatory effects of MRJP3 and its derived peptides both in vitro and in vivo. Expression of both tumor necrosis factor (TNF)-α and interleukin-6 (IL-6) mRNAs in lipopolysaccharides (LPS)-stimu...
Source: Biological and Pharmaceutical Bulletin - May 1, 2022 Category: Drugs & Pharmacology Authors: Naho Minegaki Tetsuo Koshizuka Kouki Hatasa Hiroki Kondo Hiroki Kato Miyu Tannaka Keita Takahashi Mieko Tsuji Naoki Inoue Source Type: research
Trans ‑10‑Hydroxy‑2‐Decenoic Acid Alleviates Dextran Sulfate Sodium‐Induced Colitis in Mice via Regulating the Inflammasome‐Mediated Pyroptotic Pathway and Enhancing Colonic Barrier Function
Conclusion10-HDA alleviates DSS-induced colitis by regulating the NLRP3 inflammasome-mediated pyroptotic pathway and enhancing colonic barrier function. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 27, 2022 Category: Food Science Authors: Shanshan Huang,
Ranran Tao,
Jiefei Zhou,
Linxi Qian,
Jiang Wu Tags: Research Article Source Type: research
Trans ‑10‑hydroxy‑2‑decenoic acid alleviates dextran sulfate sodium‐induced colitis in mice via regulating the inflammasome‐mediated pyroptotic pathway and enhancing colonic barrier function
Conclusion: 10-HDA alleviates DSS-induced colitis by regulating the NLRP3 inflammasome- mediated pyroptotic pathway and enhancing colonic barrier function.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 4, 2022 Category: Food Science Authors: Shanshan Huang,
Ranran Tao,
Jiefei Zhou,
Linxi Qian,
Jiang Wu Tags: Research Article Source Type: research
Evaluation of queen cell acceptance and royal jelly production between hygienic and non-hygienic honey bee ( < i > Apis mellifera < /i > ) colonies
by Khalid Ali Khan, Hamed A. Ghramh
Honey bees are crucial for pollination services globally and produce important hive products including honey, royal jelly, pollen, and propolis that are being used commercially in food, cosmetics, and alternative medicinal purposes. Among the bee products, royal jelly (RJ) has long attracted scien tists’ interest because of its importance in honey caste differentiation. The present research was carried out to determine the acceptance rate of queen cells, and RJ production between the hygienic and non-hygienic lines. Further, this study unveils the effect of pollen substitute diets on ...
Source: PLoS One - March 28, 2022 Category: Biomedical Science Authors: Khalid Ali Khan Source Type: research
Royal jelly fatty acids down-regulate ANGPTL8 expression through the decrease in HNF4 α protein in human hepatoma HepG2 cells
In this study, we investigated the effects of specific fatty acids included in RJ (RJ fatty acids), such as 10-hydroxy-2-decenoic acid, 10-hydroxydecanoic acid, and sebacic acid (SA), on expression of ANGPTL8 in human hepatoma HepG2 cells. SA markedly reduced the expression of ANGPTL8. Reporter assay revealed that SA suppressed ANGPTL8 promoter activity. In addition, we identified a functional binding site of hepatocyte nuclear factor-4α (HNF4α), a liver-enriched transcription factor, in the ANGPTL8 promoter. SA reduced the levels of HNF4α protein and the binding of HNF4α to the ANGPTL8 promoter. Moreover, siRNA knockd...
Source: Bioscience, Biotechnology, and Biochemistry - March 24, 2022 Category: Biochemistry Authors: Yuki Inoue Marina Ienaga Tetsuro Kamiya Tetsuo Adachi Mitsuhiro Ohta Hirokazu Hara Source Type: research
Front Cover: Dose ‐Dependent Effects of Royal Jelly on Estrogen‐ and Progesterone‐Induced Mammary Gland Hyperplasia in Rats
Mol. Nutr. Food Res. 2022,66,202100355DOI:10.1002/mnfr.202100355Royal jelly (RJ) is obtained from honeybee queen cells. In article number2100355, Liu and co-workers used RJ on hyperplasia of the mammary gland (HMG) in rats. RJ is demonstrated to participate in regulating the hypothalamus-pituitary-ovarian axis, subside endocrine dyscrasia induced by estrogen and progesterone, and alleviate the hyperplasia of breast tissue, implying great potential in the prevention and treatment of HMG. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - March 3, 2022 Category: Food Science Authors: Yibing Liu,
Dequn Wu,
Kang Wang,
Heng Chen,
Hao Xu,
Wencheng Zong,
Nan Zhang,
Luan Zhao,
Zheguang Lin,
Ting Ji Tags: Front Cover Source Type: research
Molecules, Vol. 27, Pages 1485: Anti-Biofilm and Anti-Hemolysis Activities of 10-Hydroxy-2-Decenoic Acid against Staphylococcus aureus
iaohui Yang
Persistent infections caused by Staphylococcus aureus biofilms pose a major threat to global public health. 10-Hydroxy-2-decenoic acid (10-HDA), a main fatty acid in royal jelly, has been shown to possess various biological activities. The purpose of this study was to explore the effects of 10-HDA on the biofilms and virulence of S. aureus and its potential molecular mechanism. Quantitative crystal violet staining indicated that 10-HDA significantly reduced the biofilm biomass at sub-minimum inhibitory concentration (MIC) levels (1/32MIC to 1/2MIC). Scanning electron microscope (SEM) observations demonstrat...
Source: Molecules - February 22, 2022 Category: Chemistry Authors: Kuankuan Gao Bei Su Jing Dai Piwu Li Ruiming Wang Xiaohui Yang Tags: Article Source Type: research
Royal jelly regulates the caspase, Bax and COX-2, TNF- α protein pathways in the fluoride exposed lung damage in rats
Tissue Cell. 2022 Feb 7;76:101754. doi: 10.1016/j.tice.2022.101754. Online ahead of print.ABSTRACTThe study was carried out on 42 male rats divided into six groups with 7 rats in each group: two control groups, two injury groups and two treatment groups. One of the control groups received a basal diet while the other one was fed a basal diet supplemented with royal jelly (RJ) (100 mg/kg). The two injury groups were given 50 mg/kg and 100 mg/kg fluoride, respectively. The two treatment groups exposed to 50 mg/kg and 100 mg/kg fluoride were both fed basal diets with RJ (100 mg/kg). Lungs were taken for histopathological exam...
Source: Tissue and Cell - February 14, 2022 Category: Cytology Authors: Abdullah Aslan Ozlem Gok Seda Beyaz Muhammed Ismail Can Gozde Parlak Ramazan Gundogdu Ibrahim Hanifi Ozercan Serpil Baspinar Source Type: research
Royal jelly regulates the caspase, Bax and COX-2, TNF- α protein pathways in the fluoride exposed lung damage in rats
Tissue Cell. 2022 Feb 7;76:101754. doi: 10.1016/j.tice.2022.101754. Online ahead of print.ABSTRACTThe study was carried out on 42 male rats divided into six groups with 7 rats in each group: two control groups, two injury groups and two treatment groups. One of the control groups received a basal diet while the other one was fed a basal diet supplemented with royal jelly (RJ) (100 mg/kg). The two injury groups were given 50 mg/kg and 100 mg/kg fluoride, respectively. The two treatment groups exposed to 50 mg/kg and 100 mg/kg fluoride were both fed basal diets with RJ (100 mg/kg). Lungs were taken for histopathological exam...
Source: Tissue and Cell - February 14, 2022 Category: Cytology Authors: Abdullah Aslan Ozlem Gok Seda Beyaz Muhammed Ismail Can Gozde Parlak Ramazan Gundogdu Ibrahim Hanifi Ozercan Serpil Baspinar Source Type: research
Genetic Drift and Purifying Selection Shaped Mitochondrial Genome Variation in the High Royal Jelly-Producing Honeybee Strain (Apis mellifera ligustica)
Mitochondrial genomes (mitogenomes) are involved in cellular energy metabolism and have been shown to undergo adaptive evolution in organisms with increased energy-consuming activities. The genetically selected high royal jelly-producing bees (RJBs, Apis mellifera ligustica) in China can produce 10 times more royal jelly, a highly nutritional and functional food, relative to unselected Italian bees (ITBs). To test for potential adaptive evolution of RJB mitochondrial genes, we sequenced mitogenomes from 100 RJBs and 30 ITBs. Haplotype network and phylogenetic analysis indicate that RJBs and ITBs are not reciprocally monoph...
Source: Frontiers in Genetics - February 9, 2022 Category: Genetics & Stem Cells Source Type: research
Insecticidal, Antimalarial, and Antileishmanial Effects of Royal Jelly and Its Three Main Fatty Acids, < em > trans < /em > -10-Hydroxy-2-decenoic Acid, 10-Hydroxydecanoic Acid, and Sebacic Acid
Evid Based Complement Alternat Med. 2022 Jan 20;2022:7425322. doi: 10.1155/2022/7425322. eCollection 2022.ABSTRACTNatural products and their derivatives as an inexpensive, accessible, and useful alternative medicine are broadly applied for the treatment of a wide range of diseases and infectious ones. The present study was designed to evaluate the insecticidal, antimalarial, antileishmanial, and cytotoxic effects of royal jelly and its three main fatty acids (trans-10-hydroxy-2-decenoic acid (10-H2DA), 10-hydroxydecanoic acid (10-HDAA), sebacic acid (1,10-decanedioic acid)). Insecticidal activity of RJ and 10-H2DA, 10-HDAA...
Source: Evidence-based Complementary and Alternative Medicine - January 31, 2022 Category: Complementary Medicine Authors: Abeer Mousa Alkhaibari Abdullah D Alanazi Source Type: research
Antifungal Effects of Iranian Propolis Extract and Royal jelly Against Candida albicans In ‑Vitro
Conclusions: The results indicate tha t both Royal jelly and Iranian Propolis alcoholic extract are effective against C. albicans, but the former species has higher antifungal activity. If the clinical trials confirm the results of this study, Iranian propolis, as a new antifungal agent by replacing chemical drugs, can be used to develo p antifungal medicinal herbs. (Source: International Journal of Preventive Medicine)
Source: International Journal of Preventive Medicine - January 17, 2022 Category: International Medicine & Public Health Source Type: research
Dose ‐Dependent Effects of Royal Jelly on Estrogen‐ and Progesterone‐Induced Mammary Gland Hyperplasia in Rats
ConclusionRJ regulates endocrine dyscrasia in HMG rats and improves the breast tissue structure, indicating its potential in the prevention and treatment on HMG. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - January 4, 2022 Category: Food Science Authors: Yibing Liu,
Dequn Wu,
Kang Wang,
Heng Chen,
Hao Xu,
Wencheng Zong,
Nan Zhang,
Luan Zhao,
Zheguang Lin,
Ting Ji Tags: Research Article Source Type: research
Dose ?Dependent Effects of Royal Jelly on Estrogen? and Progesterone?Induced Mammary Gland Hyperplasia in Rats
ConclusionRJ regulates endocrine dyscrasia in HMG rats and improves the breast tissue structure, indicating its potential in the prevention and treatment on HMG. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - January 3, 2022 Category: Food Science Authors: Yibing Liu,
Dequn Wu,
Kang Wang,
Heng Chen,
Hao Xu,
Wencheng Zong,
Nan Zhang,
Luan Zhao,
Zheguang Lin,
Ting Ji Tags: Research Article Source Type: research
