Royal Jelly Nanoparticle Alleviates Experimental Model of Breast Cancer Through Suppressing Regulatory T Cells and Upregulating TH1 Cells
CONCLUSIONS: These results indicated that royal jelly and RJ-LDH could inhibit breast cancer progression by in-hibiting regulatory T cells and expansion of Th1 cell. Furthermore, the current study demonstrated the therapeutic efficacy of royal jelly is enhanced by LDH nanoparticles; hence, RJ-LDH is significantly more efficient than Free-RJ in the treatment of breast cancer.PMID:37307122 | DOI:10.7754/Clin.Lab.2022.220917 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 12, 2023 Category: Cancer & Oncology Authors: Mohammad A Roohi Ladan Langroudi Reza Nosratabadi Mehdi Ranjbar Fardin Khajepour Mohammad R Zangouyee Source Type: research
Royal Jelly Nanoparticle Alleviates Experimental Model of Breast Cancer Through Suppressing Regulatory T Cells and Upregulating TH1 Cells
CONCLUSIONS: These results indicated that royal jelly and RJ-LDH could inhibit breast cancer progression by in-hibiting regulatory T cells and expansion of Th1 cell. Furthermore, the current study demonstrated the therapeutic efficacy of royal jelly is enhanced by LDH nanoparticles; hence, RJ-LDH is significantly more efficient than Free-RJ in the treatment of breast cancer.PMID:37307122 | DOI:10.7754/Clin.Lab.2022.220917 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - June 12, 2023 Category: Cancer & Oncology Authors: Mohammad A Roohi Ladan Langroudi Reza Nosratabadi Mehdi Ranjbar Fardin Khajepour Mohammad R Zangouyee Source Type: research
Royal jelly mediates fibrotic signaling, collagen cross-linking and cell proliferation in cardiac fibroblasts
Biomed Pharmacother. 2023 May 24;164:114922. doi: 10.1016/j.biopha.2023.114922. Online ahead of print.ABSTRACTRoyal jelly (RJ) is a multifunctional bee product with a unique composition and wide-ranging biological properties, including antioxidant, anti-inflammatory and antiproliferative activities. Still, little is known about the possible myocardial protective properties of RJ. Considering that sonication could enhance RJ bioactivity, this study aimed to assess the effects of non-sonicated (NS) and sonicated (S) RJ on fibrotic signaling, cell proliferation, and collagen production in cardiac fibroblasts. S-RJ was produce...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 26, 2023 Category: Drugs & Pharmacology Authors: Doa'a G F Al-U'datt Muhammad H Alu'datt Carole C Tranchant Ahmed Al-Dwairi Othman Al-Shboul Ali Almajwal Lina Elsalem Saied Jaradat Karem H Alzoubi Belal G Faleh Yaman B Ahmed Jenan Alqbelat Source Type: research
Royal jelly mediates fibrotic signaling, collagen cross-linking and cell proliferation in cardiac fibroblasts
Biomed Pharmacother. 2023 May 24;164:114922. doi: 10.1016/j.biopha.2023.114922. Online ahead of print.ABSTRACTRoyal jelly (RJ) is a multifunctional bee product with a unique composition and wide-ranging biological properties, including antioxidant, anti-inflammatory and antiproliferative activities. Still, little is known about the possible myocardial protective properties of RJ. Considering that sonication could enhance RJ bioactivity, this study aimed to assess the effects of non-sonicated (NS) and sonicated (S) RJ on fibrotic signaling, cell proliferation, and collagen production in cardiac fibroblasts. S-RJ was produce...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 26, 2023 Category: Drugs & Pharmacology Authors: Doa'a G F Al-U'datt Muhammad H Alu'datt Carole C Tranchant Ahmed Al-Dwairi Othman Al-Shboul Ali Almajwal Lina Elsalem Saied Jaradat Karem H Alzoubi Belal G Faleh Yaman B Ahmed Jenan Alqbelat Source Type: research
Pesticide residues in bee bread, propolis, beeswax and royal jelly - A review of the literature and dietary risk assessment
Food Chem Toxicol. 2023 Apr 28:113806. doi: 10.1016/j.fct.2023.113806. Online ahead of print.ABSTRACTDue to pollinator decline observed worldwide, many studies have been conducted on the pesticide residue content of apicultural products including bee bread, propolis, beeswax and royal jelly. These products are consumed for their nutraceutical properties, although, little information is available on the human health risk posed by pesticides present in them. In our research, studies dealing with the pesticide contamination of the above-mentioned hive products are reviewed. Dietary exposures were calculated based on the recom...
Source: Food and Chemical Toxicology - April 30, 2023 Category: Food Science Authors: Rita V égh Mariann Cs óka Zsuzsanna Medny ánszky L ászló Sipos Source Type: research
Pesticide residues in bee bread, propolis, beeswax and royal jelly - A review of the literature and dietary risk assessment
Food Chem Toxicol. 2023 Apr 28:113806. doi: 10.1016/j.fct.2023.113806. Online ahead of print.ABSTRACTDue to pollinator decline observed worldwide, many studies have been conducted on the pesticide residue content of apicultural products including bee bread, propolis, beeswax and royal jelly. These products are consumed for their nutraceutical properties, although, little information is available on the human health risk posed by pesticides present in them. In our research, studies dealing with the pesticide contamination of the above-mentioned hive products are reviewed. Dietary exposures were calculated based on the recom...
Source: Food and Chemical Toxicology - April 30, 2023 Category: Food Science Authors: Rita V égh Mariann Cs óka Zsuzsanna Medny ánszky L ászló Sipos Source Type: research
Pesticide residues in bee bread, propolis, beeswax and royal jelly - A review of the literature and dietary risk assessment
Food Chem Toxicol. 2023 Apr 28:113806. doi: 10.1016/j.fct.2023.113806. Online ahead of print.ABSTRACTDue to pollinator decline observed worldwide, many studies have been conducted on the pesticide residue content of apicultural products including bee bread, propolis, beeswax and royal jelly. These products are consumed for their nutraceutical properties, although, little information is available on the human health risk posed by pesticides present in them. In our research, studies dealing with the pesticide contamination of the above-mentioned hive products are reviewed. Dietary exposures were calculated based on the recom...
Source: Food and Chemical Toxicology - April 30, 2023 Category: Food Science Authors: Rita V égh Mariann Cs óka Zsuzsanna Medny ánszky L ászló Sipos Source Type: research
Ingestion of heat-killed pathogens confers transgenerational immunity to the pathogens via the vitellogenin-hypopharyngeal gland axis in honeybees
This study investigated whether feeding honeybees (Apis mellifera) with a heat-killed pathogen cocktail can provide them with transgenerational immunity to these pathogens. We found that vitellogenin (Vg) and defensin-1 were highly upregulated in nurse bees upon feeding them with a cocktail of heat-killed Ascosphaera apis and Paenibacillus larvae (A + P cocktail). Pathogen-pattern-recognition receptor genes in the Toll signaling pathway were upregulated in nurse bees upon ingestion of the A + P cocktail. In the nurse bees of the hives supplied with the A + P cocktail, Vg was upregulated in the fat body, and the defensin-1 ...
Source: Developmental and Comparative Immunology - April 9, 2023 Category: Allergy & Immunology Authors: Yun Hui Kim Bo Yeon Kim Yong Soo Choi Kwang Sik Lee Byung Rae Jin Source Type: research
Ingestion of heat-killed pathogens confers transgenerational immunity to the pathogens via the vitellogenin-hypopharyngeal gland axis in honeybees
This study investigated whether feeding honeybees (Apis mellifera) with a heat-killed pathogen cocktail can provide them with transgenerational immunity to these pathogens. We found that vitellogenin (Vg) and defensin-1 were highly upregulated in nurse bees upon feeding them with a cocktail of heat-killed Ascosphaera apis and Paenibacillus larvae (A + P cocktail). Pathogen-pattern-recognition receptor genes in the Toll signaling pathway were upregulated in nurse bees upon ingestion of the A + P cocktail. In the nurse bees of the hives supplied with the A + P cocktail, Vg was upregulated in the fat body, and the defensin-1 ...
Source: Developmental and Comparative Immunology - April 9, 2023 Category: Allergy & Immunology Authors: Yun Hui Kim Bo Yeon Kim Yong Soo Choi Kwang Sik Lee Byung Rae Jin Source Type: research
Ingestion of heat-killed pathogens confers transgenerational immunity to the pathogens via the vitellogenin-hypopharyngeal gland axis in honeybees
This study investigated whether feeding honeybees (Apis mellifera) with a heat-killed pathogen cocktail can provide them with transgenerational immunity to these pathogens. We found that vitellogenin (Vg) and defensin-1 were highly upregulated in nurse bees upon feeding them with a cocktail of heat-killed Ascosphaera apis and Paenibacillus larvae (A + P cocktail). Pathogen-pattern-recognition receptor genes in the Toll signaling pathway were upregulated in nurse bees upon ingestion of the A + P cocktail. In the nurse bees of the hives supplied with the A + P cocktail, Vg was upregulated in the fat body, and the defensin-1 ...
Source: Developmental and Comparative Immunology - April 9, 2023 Category: Allergy & Immunology Authors: Yun Hui Kim Bo Yeon Kim Yong Soo Choi Kwang Sik Lee Byung Rae Jin Source Type: research
Identification of royal jelly as a potential new drug to protect the ovarian reserve and uterus against cyclophosphamide in rats
CONCLUSION: According to these results, RJ reduces cyclophosphamide-related ovarian and endometrial damage in rats. For this reason, it should be further investigated to determine its effects on reproductive function.PMID:36935410 | PMC:PMC10030208 | DOI:10.5653/cerm.2022.05596 (Source: Clinical and Experimental Reproductive Medicine)
Source: Clinical and Experimental Reproductive Medicine - March 20, 2023 Category: Reproduction Medicine Authors: Mehmet Bulbul Ali Tekce Ebru Annac Omer Korkmaz Muhittin Onderci Deniz Korkmaz Akin Mustafa Demirci Source Type: research
