Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly
Biol Pharm Bull. 2023;46(2):348-353. doi: 10.1248/bpb.b22-00654.ABSTRACTRoyal jelly (RJ), an essential food for the queen honeybee, has a variety of biological activities. Although RJ exerts preventive effects on various lifestyle-related diseases, such as osteoporosis and obesity, no study evaluated the effect of RJ on the development of osteoarthritis (OA), the most common degenerative joint disease. Here, we showed that daily oral administration of raw RJ significantly prevented OA development in vivo following surgically-induced knee joint instability in mice. Furthermore, in vitro experiments using chondrocytes, revea...
Source: Biological and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Jiajun Lyu Takuya Kubo Sayuki Iwahashi Kazuya Fukasawa Tetsuhiro Horie Katashi Nagamatsu Kumiko Ikeno Genjiro Nakamura Masaki Kamakura Eiichi Hinoi Source Type: research
Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly
Biol Pharm Bull. 2023;46(2):348-353. doi: 10.1248/bpb.b22-00654.ABSTRACTRoyal jelly (RJ), an essential food for the queen honeybee, has a variety of biological activities. Although RJ exerts preventive effects on various lifestyle-related diseases, such as osteoporosis and obesity, no study evaluated the effect of RJ on the development of osteoarthritis (OA), the most common degenerative joint disease. Here, we showed that daily oral administration of raw RJ significantly prevented OA development in vivo following surgically-induced knee joint instability in mice. Furthermore, in vitro experiments using chondrocytes, revea...
Source: Biological and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Jiajun Lyu Takuya Kubo Sayuki Iwahashi Kazuya Fukasawa Tetsuhiro Horie Katashi Nagamatsu Kumiko Ikeno Genjiro Nakamura Masaki Kamakura Eiichi Hinoi Source Type: research
Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly
Biol Pharm Bull. 2023;46(2):348-353. doi: 10.1248/bpb.b22-00654.ABSTRACTRoyal jelly (RJ), an essential food for the queen honeybee, has a variety of biological activities. Although RJ exerts preventive effects on various lifestyle-related diseases, such as osteoporosis and obesity, no study evaluated the effect of RJ on the development of osteoarthritis (OA), the most common degenerative joint disease. Here, we showed that daily oral administration of raw RJ significantly prevented OA development in vivo following surgically-induced knee joint instability in mice. Furthermore, in vitro experiments using chondrocytes, revea...
Source: Biological and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Jiajun Lyu Takuya Kubo Sayuki Iwahashi Kazuya Fukasawa Tetsuhiro Horie Katashi Nagamatsu Kumiko Ikeno Genjiro Nakamura Masaki Kamakura Eiichi Hinoi Source Type: research
Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly
Biol Pharm Bull. 2023;46(2):348-353. doi: 10.1248/bpb.b22-00654.ABSTRACTRoyal jelly (RJ), an essential food for the queen honeybee, has a variety of biological activities. Although RJ exerts preventive effects on various lifestyle-related diseases, such as osteoporosis and obesity, no study evaluated the effect of RJ on the development of osteoarthritis (OA), the most common degenerative joint disease. Here, we showed that daily oral administration of raw RJ significantly prevented OA development in vivo following surgically-induced knee joint instability in mice. Furthermore, in vitro experiments using chondrocytes, revea...
Source: Biological and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Jiajun Lyu Takuya Kubo Sayuki Iwahashi Kazuya Fukasawa Tetsuhiro Horie Katashi Nagamatsu Kumiko Ikeno Genjiro Nakamura Masaki Kamakura Eiichi Hinoi Source Type: research
Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly
Biol Pharm Bull. 2023;46(2):348-353. doi: 10.1248/bpb.b22-00654.ABSTRACTRoyal jelly (RJ), an essential food for the queen honeybee, has a variety of biological activities. Although RJ exerts preventive effects on various lifestyle-related diseases, such as osteoporosis and obesity, no study evaluated the effect of RJ on the development of osteoarthritis (OA), the most common degenerative joint disease. Here, we showed that daily oral administration of raw RJ significantly prevented OA development in vivo following surgically-induced knee joint instability in mice. Furthermore, in vitro experiments using chondrocytes, revea...
Source: Biological and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Jiajun Lyu Takuya Kubo Sayuki Iwahashi Kazuya Fukasawa Tetsuhiro Horie Katashi Nagamatsu Kumiko Ikeno Genjiro Nakamura Masaki Kamakura Eiichi Hinoi Source Type: research
Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly
Biol Pharm Bull. 2023;46(2):348-353. doi: 10.1248/bpb.b22-00654.ABSTRACTRoyal jelly (RJ), an essential food for the queen honeybee, has a variety of biological activities. Although RJ exerts preventive effects on various lifestyle-related diseases, such as osteoporosis and obesity, no study evaluated the effect of RJ on the development of osteoarthritis (OA), the most common degenerative joint disease. Here, we showed that daily oral administration of raw RJ significantly prevented OA development in vivo following surgically-induced knee joint instability in mice. Furthermore, in vitro experiments using chondrocytes, revea...
Source: Biological and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Jiajun Lyu Takuya Kubo Sayuki Iwahashi Kazuya Fukasawa Tetsuhiro Horie Katashi Nagamatsu Kumiko Ikeno Genjiro Nakamura Masaki Kamakura Eiichi Hinoi Source Type: research
Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly
Biol Pharm Bull. 2023;46(2):348-353. doi: 10.1248/bpb.b22-00654.ABSTRACTRoyal jelly (RJ), an essential food for the queen honeybee, has a variety of biological activities. Although RJ exerts preventive effects on various lifestyle-related diseases, such as osteoporosis and obesity, no study evaluated the effect of RJ on the development of osteoarthritis (OA), the most common degenerative joint disease. Here, we showed that daily oral administration of raw RJ significantly prevented OA development in vivo following surgically-induced knee joint instability in mice. Furthermore, in vitro experiments using chondrocytes, revea...
Source: Biological and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Jiajun Lyu Takuya Kubo Sayuki Iwahashi Kazuya Fukasawa Tetsuhiro Horie Katashi Nagamatsu Kumiko Ikeno Genjiro Nakamura Masaki Kamakura Eiichi Hinoi Source Type: research
Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly
Biol Pharm Bull. 2023;46(2):348-353. doi: 10.1248/bpb.b22-00654.ABSTRACTRoyal jelly (RJ), an essential food for the queen honeybee, has a variety of biological activities. Although RJ exerts preventive effects on various lifestyle-related diseases, such as osteoporosis and obesity, no study evaluated the effect of RJ on the development of osteoarthritis (OA), the most common degenerative joint disease. Here, we showed that daily oral administration of raw RJ significantly prevented OA development in vivo following surgically-induced knee joint instability in mice. Furthermore, in vitro experiments using chondrocytes, revea...
Source: Biological and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Jiajun Lyu Takuya Kubo Sayuki Iwahashi Kazuya Fukasawa Tetsuhiro Horie Katashi Nagamatsu Kumiko Ikeno Genjiro Nakamura Masaki Kamakura Eiichi Hinoi Source Type: research
Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly
Biol Pharm Bull. 2023;46(2):348-353. doi: 10.1248/bpb.b22-00654.ABSTRACTRoyal jelly (RJ), an essential food for the queen honeybee, has a variety of biological activities. Although RJ exerts preventive effects on various lifestyle-related diseases, such as osteoporosis and obesity, no study evaluated the effect of RJ on the development of osteoarthritis (OA), the most common degenerative joint disease. Here, we showed that daily oral administration of raw RJ significantly prevented OA development in vivo following surgically-induced knee joint instability in mice. Furthermore, in vitro experiments using chondrocytes, revea...
Source: Biological and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Jiajun Lyu Takuya Kubo Sayuki Iwahashi Kazuya Fukasawa Tetsuhiro Horie Katashi Nagamatsu Kumiko Ikeno Genjiro Nakamura Masaki Kamakura Eiichi Hinoi Source Type: research
Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly
Biol Pharm Bull. 2023;46(2):348-353. doi: 10.1248/bpb.b22-00654.ABSTRACTRoyal jelly (RJ), an essential food for the queen honeybee, has a variety of biological activities. Although RJ exerts preventive effects on various lifestyle-related diseases, such as osteoporosis and obesity, no study evaluated the effect of RJ on the development of osteoarthritis (OA), the most common degenerative joint disease. Here, we showed that daily oral administration of raw RJ significantly prevented OA development in vivo following surgically-induced knee joint instability in mice. Furthermore, in vitro experiments using chondrocytes, revea...
Source: Biological and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Jiajun Lyu Takuya Kubo Sayuki Iwahashi Kazuya Fukasawa Tetsuhiro Horie Katashi Nagamatsu Kumiko Ikeno Genjiro Nakamura Masaki Kamakura Eiichi Hinoi Source Type: research
Feeding Asian honeybee queens with European honeybee royal jelly alters body color and expression of related coding and non-coding RNAs
Conclusion: These findings reveal that the larval diets from A. mellifera could change the body color of A. cerana, perhaps by altering the expression of non-coding RNAs and related key genes. This study serves as a model of epigenetic regulation in insect body color induced by environmental factors. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - January 26, 2023 Category: Physiology Source Type: research
Royal Jelly Increases Hematopoietic Stem Cells in Peripheral Blood: A Double-Blind, Placebo-Controlled, Randomized Trial in Healthy Subjects
Conclusion. Eligible data from 86 subjects (placebo: 42, RJ: 44) who completed the study were analyzed. There were no significant differences between the two groups regarding the changes in peripheral HSC count (p=0.103), while diastolic blood pressure showed a significant improvement in the RJ group compared to that in the placebo group (p=0.032). The subgroup analysis excluded 14 subjects who complained of cold symptoms at baseline or within five days of the four-week study. The changes in the HSC populations were significantly higher in the RJ group than those in the placebo group (p=0.042). No adverse effects were obse...
Source: Evidence-based Complementary and Alternative Medicine - January 23, 2023 Category: Complementary Medicine Authors: Hideto Okamoto Akio Ohkuma Mitsuhiko Kawaguchi Norihiro Shigematsu Nobuaki Okumura Source Type: research
Molecules, Vol. 28, Pages 996: Inhibition of Skin Pathogenic Bacteria, Antioxidant and Anti-Inflammatory Activity of Royal Jelly from Northern Thailand
ragoolpua
Royal jelly is a nutritious substance produced by the hypopharyngeal and mandibular glands of honeybees. Royal jelly possesses many attractive and beneficial properties which make it an ideal component in medical and pharmaceutical products. The antibacterial, antioxidant, and anti-inflammatory activities of royal jelly from honeybees (Apis mellifera) were determined in this study. Moreover, the total phenolic and flavonoid contents of the royal jelly were also evaluated. The effects of royal jelly on growth inhibition against skin pathogenic bacteria, including Cutibacterium acnes, methicillin-resistant Stap...
Source: Molecules - January 19, 2023 Category: Chemistry Authors: Vitchayaporn Uthaibutra Thida Kaewkod Pichet Prapawilai Hataichanok Pandith Yingmanee Tragoolpua Tags: Article Source Type: research
The use of the nutritional supplements during the covid-19 outbreak in Saudi Arabia: A cross-sectional study
CONCLUSION: The respondents' risk of these supplements' use may partially reflect the public's behavioral response during a pandemic. Future studies can document the health beliefs and motivations of nutritional supplement users.PMID:36632904 | PMC:PMC9827747 | DOI:10.1016/j.ctim.2023.102917 (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - January 12, 2023 Category: Complementary Medicine Authors: Nada Mohammed Hafiz Mahmoud Zaki El-Readi Ghada Esheba Mohammad Althubiti Nahla Ayoub Abdullah R Alzahrani Saeed S Al-Ghamdi Safaa Yehia Eid Source Type: research
