Antiviral activity of bee products
Curr Pharm Des. 2022 Sep 28. doi: 10.2174/1381612828666220928110103. Online ahead of print.ABSTRACTHoney bees provide many products exerting a wide range of benefits to humans. Honey, propolis, royal jelly, beeswax, bee venom, bee pollen and bee bread have been used as natural medicines since ancient times because of their therapeutic effects. These products have demonstrated healing properties against wounds, diabetes, gastrointestinal diseases, cancer, asthma, neurological diseases, bacterial and viral infections. The antibacterial and antibiofilm activity of honey bee products is widely studied and a huge body of eviden...
Source: Current Pharmaceutical Design - September 29, 2022 Category: Drugs & Pharmacology Authors: Theodoros Kontogiannis Tilemachos G Dimitriou Nikos Asoutis Didaras Dimitris Mossialos Source Type: research

A new approach on the regulation of NF- κB and Bax protein signaling pathway activation by royal jelly in fluoride-induced pancreas damage in rats
Tissue Cell. 2022 Aug 30;79:101913. doi: 10.1016/j.tice.2022.101913. Online ahead of print.ABSTRACTForty-two healthy adult male rats (Wistar albino, n = 42, 8 weeks old, starting weights 200-250 g) employed in this study were subdivided into six groups randomly with seven rats per group as follows: (i) Control group: received standard diet; (ii) RJ group: received standard diet supplemented with royal jelly; (iii) F50 group: received standard diet supplemented with fluoride (50 mg/kg BW); (iv) F100 group: received standard diet supplemented with fluoride (100 mg/kg BW); (v) F50 +RJ group: received standard diet supplemente...
Source: Tissue and Cell - September 12, 2022 Category: Cytology Authors: Abdullah Aslan Muhammed Ismail Can Seda Beyaz Ozlem Gok Gozde Parlak Ramazan Gundogdu Ibrahim Hanifi Ozercan Orhan Erman Source Type: research

A new approach on the regulation of NF- κB and Bax protein signaling pathway activation by royal jelly in fluoride-induced pancreas damage in rats
Tissue Cell. 2022 Aug 30;79:101913. doi: 10.1016/j.tice.2022.101913. Online ahead of print.ABSTRACTForty-two healthy adult male rats (Wistar albino, n = 42, 8 weeks old, starting weights 200-250 g) employed in this study were subdivided into six groups randomly with seven rats per group as follows: (i) Control group: received standard diet; (ii) RJ group: received standard diet supplemented with royal jelly; (iii) F50 group: received standard diet supplemented with fluoride (50 mg/kg BW); (iv) F100 group: received standard diet supplemented with fluoride (100 mg/kg BW); (v) F50 +RJ group: received standard diet supplemente...
Source: Tissue and Cell - September 12, 2022 Category: Cytology Authors: Abdullah Aslan Muhammed Ismail Can Seda Beyaz Ozlem Gok Gozde Parlak Ramazan Gundogdu Ibrahim Hanifi Ozercan Orhan Erman Source Type: research

A new approach on the regulation of NF- κB and Bax protein signaling pathway activation by royal jelly in fluoride-induced pancreas damage in rats
Tissue Cell. 2022 Aug 30;79:101913. doi: 10.1016/j.tice.2022.101913. Online ahead of print.ABSTRACTForty-two healthy adult male rats (Wistar albino, n = 42, 8 weeks old, starting weights 200-250 g) employed in this study were subdivided into six groups randomly with seven rats per group as follows: (i) Control group: received standard diet; (ii) RJ group: received standard diet supplemented with royal jelly; (iii) F50 group: received standard diet supplemented with fluoride (50 mg/kg BW); (iv) F100 group: received standard diet supplemented with fluoride (100 mg/kg BW); (v) F50 +RJ group: received standard diet supplemente...
Source: Tissue and Cell - September 12, 2022 Category: Cytology Authors: Abdullah Aslan Muhammed Ismail Can Seda Beyaz Ozlem Gok Gozde Parlak Ramazan Gundogdu Ibrahim Hanifi Ozercan Orhan Erman Source Type: research

A new approach on the regulation of NF- κB and Bax protein signaling pathway activation by royal jelly in fluoride-induced pancreas damage in rats
Tissue Cell. 2022 Aug 30;79:101913. doi: 10.1016/j.tice.2022.101913. Online ahead of print.ABSTRACTForty-two healthy adult male rats (Wistar albino, n = 42, 8 weeks old, starting weights 200-250 g) employed in this study were subdivided into six groups randomly with seven rats per group as follows: (i) Control group: received standard diet; (ii) RJ group: received standard diet supplemented with royal jelly; (iii) F50 group: received standard diet supplemented with fluoride (50 mg/kg BW); (iv) F100 group: received standard diet supplemented with fluoride (100 mg/kg BW); (v) F50 +RJ group: received standard diet supplemente...
Source: Tissue and Cell - September 12, 2022 Category: Cytology Authors: Abdullah Aslan Muhammed Ismail Can Seda Beyaz Ozlem Gok Gozde Parlak Ramazan Gundogdu Ibrahim Hanifi Ozercan Orhan Erman Source Type: research

A new approach on the regulation of NF- κB and Bax protein signaling pathway activation by royal jelly in fluoride-induced pancreas damage in rats
Tissue Cell. 2022 Aug 30;79:101913. doi: 10.1016/j.tice.2022.101913. Online ahead of print.ABSTRACTForty-two healthy adult male rats (Wistar albino, n = 42, 8 weeks old, starting weights 200-250 g) employed in this study were subdivided into six groups randomly with seven rats per group as follows: (i) Control group: received standard diet; (ii) RJ group: received standard diet supplemented with royal jelly; (iii) F50 group: received standard diet supplemented with fluoride (50 mg/kg BW); (iv) F100 group: received standard diet supplemented with fluoride (100 mg/kg BW); (v) F50 +RJ group: received standard diet supplemente...
Source: Tissue and Cell - September 12, 2022 Category: Cytology Authors: Abdullah Aslan Muhammed Ismail Can Seda Beyaz Ozlem Gok Gozde Parlak Ramazan Gundogdu Ibrahim Hanifi Ozercan Orhan Erman Source Type: research

Evaluation of the estrogenic action potential of royal jelly by genomic signaling pathway in vitro and in vivo
Biol Pharm Bull. 2022 Aug 2. doi: 10.1248/bpb.b22-00383. Online ahead of print.ABSTRACTRoyal jelly (RJ) has beneficial effects on human health, and some of these effects are reported to be the result of its estrogenic activity; however, chemicals with estrogenic activities may disrupt physiological estrogen signaling leading to adverse effects on human health. Thus, clarification of the mode of action of RJ is needed. Here, we investigated whether the estrogen-like actions of RJ are induced via estrogen receptors (ERs)-mediated genomic actions by using an in vitro reporter assay in human choriocarcinoma JEG3 cells and an e...
Source: Biological and Pharmaceutical Bulletin - August 4, 2022 Category: Drugs & Pharmacology Authors: Keishi Ishida Daisuke Matsumaru Shinya Shimizu Youhei Hiromori Hisamitsu Nagase Tsuyoshi Nakanishi Source Type: research

Evaluation of the estrogenic action potential of royal jelly by genomic signaling pathway in vitro and in vivo
Biol Pharm Bull. 2022 Aug 2. doi: 10.1248/bpb.b22-00383. Online ahead of print.ABSTRACTRoyal jelly (RJ) has beneficial effects on human health, and some of these effects are reported to be the result of its estrogenic activity; however, chemicals with estrogenic activities may disrupt physiological estrogen signaling leading to adverse effects on human health. Thus, clarification of the mode of action of RJ is needed. Here, we investigated whether the estrogen-like actions of RJ are induced via estrogen receptors (ERs)-mediated genomic actions by using an in vitro reporter assay in human choriocarcinoma JEG3 cells and an e...
Source: Biological and Pharmaceutical Bulletin - August 4, 2022 Category: Drugs & Pharmacology Authors: Keishi Ishida Daisuke Matsumaru Shinya Shimizu Youhei Hiromori Hisamitsu Nagase Tsuyoshi Nakanishi Source Type: research

Evaluation of the estrogenic action potential of royal jelly by genomic signaling pathway in vitro and in vivo
Biol Pharm Bull. 2022 Aug 2. doi: 10.1248/bpb.b22-00383. Online ahead of print.ABSTRACTRoyal jelly (RJ) has beneficial effects on human health, and some of these effects are reported to be the result of its estrogenic activity; however, chemicals with estrogenic activities may disrupt physiological estrogen signaling leading to adverse effects on human health. Thus, clarification of the mode of action of RJ is needed. Here, we investigated whether the estrogen-like actions of RJ are induced via estrogen receptors (ERs)-mediated genomic actions by using an in vitro reporter assay in human choriocarcinoma JEG3 cells and an e...
Source: Biological and Pharmaceutical Bulletin - August 4, 2022 Category: Drugs & Pharmacology Authors: Keishi Ishida Daisuke Matsumaru Shinya Shimizu Youhei Hiromori Hisamitsu Nagase Tsuyoshi Nakanishi Source Type: research

Evaluation of the estrogenic action potential of royal jelly by genomic signaling pathway in vitro and in vivo
Biol Pharm Bull. 2022 Aug 2. doi: 10.1248/bpb.b22-00383. Online ahead of print.ABSTRACTRoyal jelly (RJ) has beneficial effects on human health, and some of these effects are reported to be the result of its estrogenic activity; however, chemicals with estrogenic activities may disrupt physiological estrogen signaling leading to adverse effects on human health. Thus, clarification of the mode of action of RJ is needed. Here, we investigated whether the estrogen-like actions of RJ are induced via estrogen receptors (ERs)-mediated genomic actions by using an in vitro reporter assay in human choriocarcinoma JEG3 cells and an e...
Source: Biological and Pharmaceutical Bulletin - August 4, 2022 Category: Drugs & Pharmacology Authors: Keishi Ishida Daisuke Matsumaru Shinya Shimizu Youhei Hiromori Hisamitsu Nagase Tsuyoshi Nakanishi Source Type: research

Evaluation of the estrogenic action potential of royal jelly by genomic signaling pathway in vitro and in vivo
Biol Pharm Bull. 2022 Aug 2. doi: 10.1248/bpb.b22-00383. Online ahead of print.ABSTRACTRoyal jelly (RJ) has beneficial effects on human health, and some of these effects are reported to be the result of its estrogenic activity; however, chemicals with estrogenic activities may disrupt physiological estrogen signaling leading to adverse effects on human health. Thus, clarification of the mode of action of RJ is needed. Here, we investigated whether the estrogen-like actions of RJ are induced via estrogen receptors (ERs)-mediated genomic actions by using an in vitro reporter assay in human choriocarcinoma JEG3 cells and an e...
Source: Biological and Pharmaceutical Bulletin - August 4, 2022 Category: Drugs & Pharmacology Authors: Keishi Ishida Daisuke Matsumaru Shinya Shimizu Youhei Hiromori Hisamitsu Nagase Tsuyoshi Nakanishi Source Type: research

Evaluation of the estrogenic action potential of royal jelly by genomic signaling pathway in vitro and in vivo
Biol Pharm Bull. 2022 Aug 2. doi: 10.1248/bpb.b22-00383. Online ahead of print.ABSTRACTRoyal jelly (RJ) has beneficial effects on human health, and some of these effects are reported to be the result of its estrogenic activity; however, chemicals with estrogenic activities may disrupt physiological estrogen signaling leading to adverse effects on human health. Thus, clarification of the mode of action of RJ is needed. Here, we investigated whether the estrogen-like actions of RJ are induced via estrogen receptors (ERs)-mediated genomic actions by using an in vitro reporter assay in human choriocarcinoma JEG3 cells and an e...
Source: Biological and Pharmaceutical Bulletin - August 4, 2022 Category: Drugs & Pharmacology Authors: Keishi Ishida Daisuke Matsumaru Shinya Shimizu Youhei Hiromori Hisamitsu Nagase Tsuyoshi Nakanishi Source Type: research

Evaluation of the estrogenic action potential of royal jelly by genomic signaling pathway in vitro and in vivo
Biol Pharm Bull. 2022 Aug 2. doi: 10.1248/bpb.b22-00383. Online ahead of print.ABSTRACTRoyal jelly (RJ) has beneficial effects on human health, and some of these effects are reported to be the result of its estrogenic activity; however, chemicals with estrogenic activities may disrupt physiological estrogen signaling leading to adverse effects on human health. Thus, clarification of the mode of action of RJ is needed. Here, we investigated whether the estrogen-like actions of RJ are induced via estrogen receptors (ERs)-mediated genomic actions by using an in vitro reporter assay in human choriocarcinoma JEG3 cells and an e...
Source: Biological and Pharmaceutical Bulletin - August 4, 2022 Category: Drugs & Pharmacology Authors: Keishi Ishida Daisuke Matsumaru Shinya Shimizu Youhei Hiromori Hisamitsu Nagase Tsuyoshi Nakanishi Source Type: research

Evaluation of the estrogenic action potential of royal jelly by genomic signaling pathway in vitro and in vivo
Biol Pharm Bull. 2022 Aug 2. doi: 10.1248/bpb.b22-00383. Online ahead of print.ABSTRACTRoyal jelly (RJ) has beneficial effects on human health, and some of these effects are reported to be the result of its estrogenic activity; however, chemicals with estrogenic activities may disrupt physiological estrogen signaling leading to adverse effects on human health. Thus, clarification of the mode of action of RJ is needed. Here, we investigated whether the estrogen-like actions of RJ are induced via estrogen receptors (ERs)-mediated genomic actions by using an in vitro reporter assay in human choriocarcinoma JEG3 cells and an e...
Source: Biological and Pharmaceutical Bulletin - August 4, 2022 Category: Drugs & Pharmacology Authors: Keishi Ishida Daisuke Matsumaru Shinya Shimizu Youhei Hiromori Hisamitsu Nagase Tsuyoshi Nakanishi Source Type: research

Evaluation of the estrogenic action potential of royal jelly by genomic signaling pathway in vitro and in vivo
Biol Pharm Bull. 2022 Aug 2. doi: 10.1248/bpb.b22-00383. Online ahead of print.ABSTRACTRoyal jelly (RJ) has beneficial effects on human health, and some of these effects are reported to be the result of its estrogenic activity; however, chemicals with estrogenic activities may disrupt physiological estrogen signaling leading to adverse effects on human health. Thus, clarification of the mode of action of RJ is needed. Here, we investigated whether the estrogen-like actions of RJ are induced via estrogen receptors (ERs)-mediated genomic actions by using an in vitro reporter assay in human choriocarcinoma JEG3 cells and an e...
Source: Biological and Pharmaceutical Bulletin - August 4, 2022 Category: Drugs & Pharmacology Authors: Keishi Ishida Daisuke Matsumaru Shinya Shimizu Youhei Hiromori Hisamitsu Nagase Tsuyoshi Nakanishi Source Type: research