Royal jelly arranges apoptotic and oxidative stress pathways and reduces damage to liver tissues of rats by down-regulation of Bcl-2, GSK3 and NF- κB and up-regulation of Caspase and Nrf-2 protein signaling pathways
CONCLUSION: Our findings suggest RJ to be used as a hepatoprotective agent in the clinic to modulate the toxic effects of fluoride and other chemicals in the future.PMID:36520139 | DOI:10.1080/1354750X.2022.2159526 (Source: Biomarkers)
Source: Biomarkers - December 15, 2022 Category: Research Authors: Abdullah Aslan Ozlem Gok Seda Beyaz Gozde Parlak Muhammed Ismail Can Ramazan Gundogdu Serpil Baspinar Ibrahim Hanifi Ozercan Akif Evren Parlak Source Type: research
Royal jelly arranges apoptotic and oxidative stress pathways and reduces damage to liver tissues of rats by down-regulation of Bcl-2, GSK3 and NF- κB and up-regulation of caspase and Nrf-2 protein signalling pathways
CONCLUSION: Our findings suggest RJ to be used as a hepatoprotective agent in the clinic to modulate the toxic effects of fluoride and other chemicals in the future.PMID:36520139 | DOI:10.1080/1354750X.2022.2159526 (Source: Biomarkers)
Source: Biomarkers - December 15, 2022 Category: Research Authors: Abdullah Aslan Ozlem Gok Seda Beyaz Gozde Parlak Muhammed Ismail Can Ramazan Gundogdu Serpil Baspinar Ibrahim Hanifi Ozercan Akif Evren Parlak Source Type: research
Natural compounds targeting nuclear receptors for effective cancer therapy
AbstractHuman nuclear receptors (NRs) are a family of forty-eight transcription factors that modulate gene expression both spatially and temporally. Numerous biochemical, physiological, and pathological processes including cell survival, proliferation, differentiation, metabolism, immune modulation, development, reproduction, and aging are extensively orchestrated by different NRs. The involvement of dysregulated NRs and NR-mediated signaling pathways in driving cancer cell hallmarks has been thoroughly investigated. Targeting NRs has been one of the major focuses of drug development strategies for cancer interventions. In...
Source: Cancer and Metastasis Reviews - December 8, 2022 Category: Cancer & Oncology Source Type: research
Ameliorative effects of propolis and royal jelly against CCl4-induced hepatotoxicity and nephrotoxicity in Wistar rats
Chem Biodivers. 2022 Nov 23. doi: 10.1002/cbdv.202200948. Online ahead of print.ABSTRACTCarbon tetrachloride (CCl4) is known to have hepatotoxic and nephrotoxic effects. During the two-month CCl4 exposure of Wistar rats, propolis extract (PE) and royal jelly (RJ) were added in order to test the potential protective effect against hepato-renal injury. Ketonuria, proteinuria, high creatinine and urea levels are the result of CCl4-induced nephrotoxicity. Severe disorders of hematological indicators indicate anemia; high values of leukocytes indicate inflammatory condition. Cytogenetic impairments in hepatocytes, aggregation o...
Source: Chemistry and Biodiversity - November 23, 2022 Category: Biochemistry Authors: Muhamed Focak Damir Suljevic Source Type: research
Major royal jelly proteins influence the neurobiological regulation of the division of labor among honey bee workers
Int J Biol Macromol. 2022 Nov 19:S0141-8130(22)02709-X. doi: 10.1016/j.ijbiomac.2022.11.150. Online ahead of print.ABSTRACTAge-based division of labor among workers is a fundamental life-history trait of many social insects, including the Western honey bee, Apis mellifera L. Extensive studies of the causation of the most pronounced transition from performing tasks in the nest to outside foraging indicate hormonal regulation of complex physiological changes. However, the proximate neurobiological mechanisms that cause the behavioral repertoire to change are still not understood and require novel approaches to be fully chara...
Source: International Journal of Biological Macromolecules - November 22, 2022 Category: Biochemistry Authors: Yu Fang Mao Feng Chuan Ma Olav Rueppell Jianke Li Source Type: research
Major royal jelly proteins influence the neurobiological regulation of the division of labor among honey bee workers
Int J Biol Macromol. 2022 Nov 19:S0141-8130(22)02709-X. doi: 10.1016/j.ijbiomac.2022.11.150. Online ahead of print.ABSTRACTAge-based division of labor among workers is a fundamental life-history trait of many social insects, including the Western honey bee, Apis mellifera L. Extensive studies of the causation of the most pronounced transition from performing tasks in the nest to outside foraging indicate hormonal regulation of complex physiological changes. However, the proximate neurobiological mechanisms that cause the behavioral repertoire to change are still not understood and require novel approaches to be fully chara...
Source: International Journal of Biological Macromolecules - November 22, 2022 Category: Biochemistry Authors: Yu Fang Mao Feng Chuan Ma Olav Rueppell Jianke Li Source Type: research
Protective effects of royal jelly and Echinacea against moxifloxacin-induced renal and hepatic injury in rats
Volume 46, Issue 6, November 2023, Page 1193-1202 . (Source: Drug and Chemical Toxicology)
Source: Drug and Chemical Toxicology - November 2, 2022 Category: Toxicology Authors: Rasha E. MostafaNermeen M. ShaffieRasha M. Allama Department of Pharmacology, Medical Research and Clinical Studies Institute, National Research Centre (ID: 60014618), Cairo, Egyptb Department of Pathology, Medical Research and Clinical Studies Institute, Source Type: research
Protective effects of royal jelly and Echinacea against moxifloxacin-induced renal and hepatic injury in rats
. (Source: Drug and Chemical Toxicology)
Source: Drug and Chemical Toxicology - November 2, 2022 Category: Toxicology Authors: Rasha E. Mostafa Nermeen M. Shaffie Rasha M. Allam Source Type: research
A novel 3D-electrospun nanofibers-scaffold grafted with Royal Jelly: improve hydrophilicity of the nanofibers-scaffold and proliferation of HUVEC cell line
In this study, a nanofibers-grafted scaffold was prepared with two-nozzle electrospinning to serve as a tissue engineering scaffold. Fundamental physical characterizations were carried out by scanning electron microscopy (SEM), pore diameter determination, and FT-IR. Fundamental physical characterization revealed that the nanofibers-scaffolds grafted with Royal Jelly significantly increased hydrophilicity, but the porosity of the novel-nanofibers did not alter significantly than the nanofibers without Royal Jelly. Based on the MTT assay results, cell growth, survival, and proliferation of the HUVEC Cell line were increased...
Source: Cell and Tissue Banking - October 25, 2022 Category: Stem Cells Source Type: research
Antifungal and antibiofilm activities of bee venom loaded on chitosan nanoparticles: a novel approach for combating fungal human pathogens
AbstractThe prevalence of opportunistic human fungal pathogens is increasing worldwide, and antimicrobial resistance is one of the greatest medical challenges the world faces. Therefore, this study aimed to develop a novel agent to control fungal pathogens. The honeybee products (honey, royal jelly, propolis, bee bread, and bee venom) were screened against unicellular fungal (UCF) pathogens (Cryptococcus neoformans,Kodamaea ohmeri, andCandida albicans) and the bee venom was only exhibited an inhibitory effect against them. The protein contents of crude bee venom were separated using the gel filtration technique into eight ...
Source: World Journal of Microbiology and Biotechnology - October 25, 2022 Category: Microbiology Source Type: research
Effect of queen cell numbers on royal jelly production and quality
Curr Res Food Sci. 2022 Oct 11;5:1818-1825. doi: 10.1016/j.crfs.2022.10.014. eCollection 2022.ABSTRACTRoyal jelly (RJ) is a popular functional food with a wealth of health-promoting effects. Over 90% of the global RJ is produced in China mainly by a high RJ-producing honeybee (RJB) strain that can accept and feed a great number of queen larvae for RJ production. To elucidate RJ changes due to queen cell numbers (QCNs), we compared the yield, larval acceptance rate, metabolic and proteomic profiles, and antioxidant activities of RJ from 1 to 5 strips of queen cells (64 per strip) in RJB colonies. As QCNs increased, the larv...
Source: Cell Research - October 18, 2022 Category: Cytology Authors: Chuan Ma Buajiram Ahmat Jianke Li Source Type: research
Antiviral activity of bee products
Curr Pharm Des. 2022 Sep 28. doi: 10.2174/1381612828666220928110103. Online ahead of print.ABSTRACTHoney bees provide many products exerting a wide range of benefits to humans. Honey, propolis, royal jelly, beeswax, bee venom, bee pollen and bee bread have been used as natural medicines since ancient times because of their therapeutic effects. These products have demonstrated healing properties against wounds, diabetes, gastrointestinal diseases, cancer, asthma, neurological diseases, bacterial and viral infections. The antibacterial and antibiofilm activity of honey bee products is widely studied and a huge body of eviden...
Source: Current Pharmaceutical Design - September 29, 2022 Category: Drugs & Pharmacology Authors: Theodoros Kontogiannis Tilemachos G Dimitriou Nikos Asoutis Didaras Dimitris Mossialos Source Type: research
