Network pharmacology and molecular docking reveal the immunomodulatory mechanism of rhubarb peony decoction for the treatment of ulcerative colitis and irritable bowel syndrome
Conclusion: RPD may exert the overall treatment effect for UC and IBS overlap syndrome via the biological mechanism of "multi-ingredients, multi-targets, and multi-pathways" on inflammation, oxidative stress, immune, oncogenicity, and gut microbiota dysbiosis.PMID:37305432 | PMC:PMC10248730 | DOI:10.3389/jpps.2023.11225 (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - June 12, 2023 Category: Drugs & Pharmacology Authors: Leilei Zhai Weiming Yang Dianrong Li Wei Zhou Min Cui Ping Yao Source Type: research
Network pharmacology and molecular docking reveal the immunomodulatory mechanism of rhubarb peony decoction for the treatment of ulcerative colitis and irritable bowel syndrome
Conclusion: RPD may exert the overall treatment effect for UC and IBS overlap syndrome via the biological mechanism of "multi-ingredients, multi-targets, and multi-pathways" on inflammation, oxidative stress, immune, oncogenicity, and gut microbiota dysbiosis.PMID:37305432 | PMC:PMC10248730 | DOI:10.3389/jpps.2023.11225 (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - June 12, 2023 Category: Drugs & Pharmacology Authors: Leilei Zhai Weiming Yang Dianrong Li Wei Zhou Min Cui Ping Yao Source Type: research
The elucidation of the anti-inflammatory mechanism of EMO in rheumatoid arthritis through an integrative approach combining bioinformatics and experimental verification
Conclusion: Our research shows that EMO inhibits inflammatory response of rheumatoid arthritis (RA) by targeting HMGB1, STAT1, EGR1, NR3C1, EGFR, MAPK14, CASP3, CASP1, IL4, IL13, IKBKB, FN1 and Monocytes/macrophages. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 1, 2023 Category: Drugs & Pharmacology Source Type: research
Neuroprotective effect of aloe emodin against Huntington's disease-like symptoms in R6/1 transgenic mice
Food Funct. 2023 May 16. doi: 10.1039/d3fo00156c. Online ahead of print.ABSTRACTAloe emodin is a natural anthraquinone derived from aloe or rhubarb, showing anti-renal fibrosis, anti-atherosclerosis and anti-cancer effects. Aloe emodin also shows neuroprotective effects in ischemic stroke rats. Naturally, anthraquinone derivatives generally have the effect of inhibiting the transforming growth factor-β1 (TGF-β1) pathway. There is an increase in the calcium/calmodulin-dependent protein kinase II (CaMKII) and TGF-β1 levels in both Huntington's disease (HD) patients' brains and HD transgenic mice. Thus, we hypothesized tha...
Source: Atherosclerosis - May 16, 2023 Category: Cardiology Authors: Nan Yan Shuai Wang Haotian Gao Jiaqi Chen Jiahui Cao Pengsheng Wei Xue Li Ying Yu Yan Wang Yalin Niu Yijie Wang Shuyuan Liu Ge Jin Source Type: research
Neuroprotective effect of aloe emodin against Huntington's disease-like symptoms in R6/1 transgenic mice
Food Funct. 2023 May 16. doi: 10.1039/d3fo00156c. Online ahead of print.ABSTRACTAloe emodin is a natural anthraquinone derived from aloe or rhubarb, showing anti-renal fibrosis, anti-atherosclerosis and anti-cancer effects. Aloe emodin also shows neuroprotective effects in ischemic stroke rats. Naturally, anthraquinone derivatives generally have the effect of inhibiting the transforming growth factor-β1 (TGF-β1) pathway. There is an increase in the calcium/calmodulin-dependent protein kinase II (CaMKII) and TGF-β1 levels in both Huntington's disease (HD) patients' brains and HD transgenic mice. Thus, we hypothesized tha...
Source: Atherosclerosis - May 16, 2023 Category: Cardiology Authors: Nan Yan Shuai Wang Haotian Gao Jiaqi Chen Jiahui Cao Pengsheng Wei Xue Li Ying Yu Yan Wang Yalin Niu Yijie Wang Shuyuan Liu Ge Jin Source Type: research
The chemometric study of multi-elemental composition in cultivated rhubarb from Iraq Kurdish Region and T ürkiye Siirt
. (Source: International Journal of Environmental Analytical Chemistry)
Source: International Journal of Environmental Analytical Chemistry - May 15, 2023 Category: Chemistry Authors: Ibrahim Te ğin Bakhtiyar Mahmood Fattah Gurbet Canpolat Orhan Acar Source Type: research
Lactulose regulates gut microbiota dysbiosis and promotes short-chain fatty acids production in acute pancreatitis patients with intestinal dysfunction
CONCLUSIONS: Lactulose could not only restore intestinal function but also regulate gut microbiota and promote the production of SCFAs.PMID:37116350 | DOI:10.1016/j.biopha.2023.114769 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 28, 2023 Category: Drugs & Pharmacology Authors: Jinyun Wang Meilan Jiang Yang Hu Yupeng Lei Yin Zhu Huifang Xiong Cong He Source Type: research
Lactulose regulates gut microbiota dysbiosis and promotes short-chain fatty acids production in acute pancreatitis patients with intestinal dysfunction
CONCLUSIONS: Lactulose could not only restore intestinal function but also regulate gut microbiota and promote the production of SCFAs.PMID:37116350 | DOI:10.1016/j.biopha.2023.114769 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 28, 2023 Category: Drugs & Pharmacology Authors: Jinyun Wang Meilan Jiang Yang Hu Yupeng Lei Yin Zhu Huifang Xiong Cong He Source Type: research
Molecules, Vol. 28, Pages 3786: Stilbenes, a Versatile Class of Natural Metabolites for Inflammation & mdash;An Overview
Molecules, Vol. 28, Pages 3786: Stilbenes, a Versatile Class of Natural Metabolites for Inflammation—An Overview
Molecules doi: 10.3390/molecules28093786
Authors:
Jameel M. Al-Khayri
Roseanne Mascarenhas
Himanshu Madapur Harish
Yashwanth Gowda
Vasantha Veerappa Lakshmaiah
Praveen Nagella
Muneera Qassim Al-Mssallem
Fatima Mohammed Alessa
Mustafa Ibrahim Almaghasla
Adel Abdel-Sabour Rezk
Stilbenes are polyphenolic allelochemicals synthesized by plants, especially grapes, peanuts, rhubarb, berries, etc., to defend themselves under stressful conditions. They are now exploited in medicine for...
Source: Molecules - April 28, 2023 Category: Chemistry Authors: Jameel M. Al-Khayri Roseanne Mascarenhas Himanshu Madapur Harish Yashwanth Gowda Vasantha Veerappa Lakshmaiah Praveen Nagella Muneera Qassim Al-Mssallem Fatima Mohammed Alessa Mustafa Ibrahim Almaghasla Adel Abdel-Sabour Rezk Tags: Review Source Type: research
Clinical effect of rhubarb on the treatment of chronic renal failure: A meta-analysis
Conclusion: This systematic review and meta-analysis demonstrated that rhubarb has a positive therapeutic effect, which may provide confifidence and some theoretical reference for clinical application to a certain extent. Compared with the control group, rhubarb alone or traditional Chinese medicine compound containing Rhubarb can significantly reduce Serum creatinine, Blood urea nitrogen and Uric acid, increase Creatinine clearance rate, and improve the total effective rate of symptoms and signs. However, there is no evidence that rhubarb is more effective than the control group in increasing hemoglobin. In addition, due ...
Source: Frontiers in Pharmacology - April 20, 2023 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 28, Pages 3206: Analytical Methods for Oxalate Quantification: The Ubiquitous Organic Anion
VanWert
Oxalate is a divalent organic anion that affects many biological and commercial processes. It is derived from plant sources, such as spinach, rhubarb, tea, cacao, nuts, and beans, and therefore is commonly found in raw or processed food products. Oxalate can also be made endogenously by humans and other mammals as a byproduct of hepatic enzymatic reactions. It is theorized that plants use oxalate to store calcium and protect against herbivory. Clinically, oxalate is best known to be a major component of kidney stones, which commonly contain calcium oxalate crystals. Oxalate can induce an inflammatory response t...
Source: Molecules - April 4, 2023 Category: Chemistry Authors: Bryan Misiewicz Donald Mencer William Terzaghi Adam L. VanWert Tags: Review Source Type: research
Efficacy of Qifu Lizhong enema prescription on intestinal mucosal tight junction function modulation of ulcerative colitis rat model
CONCLUSIONS: The mechanism of repairing TJ function and repairing the intestinal mucosal barrier by QFLZ may be associated with up-regulation of claudin 1, ZO-1, and F-actin levels, and down-regulation of claudin 2 expression level.PMID:36994518 | DOI:10.19852/j.cnki.jtcm.20220922.002 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 30, 2023 Category: Complementary Medicine Authors: Cheng Jing L ü Shangbin Zhang Yi H U Shuangyuan Wei Pengfei Zhou Wenhua Shi Junfeng Source Type: research
Efficacy of Qifu Lizhong enema prescription on intestinal mucosal tight junction function modulation of ulcerative colitis rat model
CONCLUSIONS: The mechanism of repairing TJ function and repairing the intestinal mucosal barrier by QFLZ may be associated with up-regulation of claudin 1, ZO-1, and F-actin levels, and down-regulation of claudin 2 expression level.PMID:36994518 | DOI:10.19852/j.cnki.jtcm.20220922.002 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 30, 2023 Category: Complementary Medicine Authors: Cheng Jing L ü Shangbin Zhang Yi H U Shuangyuan Wei Pengfei Zhou Wenhua Shi Junfeng Source Type: research
Efficacy of Qifu Lizhong enema prescription on intestinal mucosal tight junction function modulation of ulcerative colitis rat model
CONCLUSIONS: The mechanism of repairing TJ function and repairing the intestinal mucosal barrier by QFLZ may be associated with up-regulation of claudin 1, ZO-1, and F-actin levels, and down-regulation of claudin 2 expression level.PMID:36994518 | DOI:10.19852/j.cnki.jtcm.20220922.002 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 30, 2023 Category: Complementary Medicine Authors: Cheng Jing L ü Shangbin Zhang Yi H U Shuangyuan Wei Pengfei Zhou Wenhua Shi Junfeng Source Type: research
