Molecules, Vol. 28, Pages 3786: Stilbenes, a Versatile Class of Natural Metabolites for Inflammation & mdash;An Overview

Molecules, Vol. 28, Pages 3786: Stilbenes, a Versatile Class of Natural Metabolites for Inflammation—An Overview Molecules doi: 10.3390/molecules28093786 Authors: Jameel M. Al-Khayri Roseanne Mascarenhas Himanshu Madapur Harish Yashwanth Gowda Vasantha Veerappa Lakshmaiah Praveen Nagella Muneera Qassim Al-Mssallem Fatima Mohammed Alessa Mustafa Ibrahim Almaghasla Adel Abdel-Sabour Rezk Stilbenes are polyphenolic allelochemicals synthesized by plants, especially grapes, peanuts, rhubarb, berries, etc., to defend themselves under stressful conditions. They are now exploited in medicine for their antioxidant, anti-proliferative and anti-inflammatory properties. Inflammation is the immune system’s response to invading bacteria, toxic chemicals or even nutrient-deprived conditions. It is characterized by the release of cytokines which can wreak havoc on healthy tissues, worsening the disease condition. Stilbenes modulate NF-κB, MAPK and JAK/STAT pathways, and reduce the transcription of inflammatory factors which result in maintenance of homeostatic conditions. Resveratrol, the most studied stilbene, lowers the Michaelis constant of SIRT1, and occupies the substrate binding pocket. Gigantol interferes with the complement system. Besides these, oxyresveratrol, pterostilbene, polydatin, viniferins, etc., are front runners as drug candidates due to their diverse effects from different functional groups that affect bioava...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research