Effects of aloe-emodin on alveolar bone in < em > Porphyromonas gingivalis < /em > -induced periodontitis rat model: a pilot study
CONCLUSIONS: AE decreases alveolar bone loss and periodontal inflammation, suggesting that this natural anthraquinone has potential value as a novel therapeutic agent against periodontal disease.PMID:36302645 | PMC:PMC9614176 | DOI:10.5051/jpis.2104060203 (Source: Journal of Periodontal and Implant Science)
Source: Journal of Periodontal and Implant Science - October 27, 2022 Category: Dentistry Authors: Ming Yang Saroj K Shrestha Yunjo Soh Seok-Mo Heo Source Type: research
Molecules, Vol. 27, Pages 6572: Research Progress on the Positive and Negative Regulatory Effects of Rhein on the Kidney: A Review of Its Molecular Targets
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Xufeng Tao
Currently, both acute kidney injury (AKI) and chronic kidney disease (CKD) are considered to be the leading public health problems with gradually increasing incidence rates around the world. Rhein is a monomeric component of anthraquinone isolated from rhubarb, a traditional Chinese medicine. It has anti-inflammation, anti-oxidation, anti-apoptosis, anti-bacterial and other pharmacological activities, as well as a renal protective effects. Rhein exerts its nephroprotective effects mainly through decreasing hypoglycemic and hypolipidemic, playing anti-inflammatory, antioxidant and anti-fibrotic effects a...
Source: Molecules - October 4, 2022 Category: Chemistry Authors: Yanna Zhu Shilei Yang Linlin Lv Xiaohan Zhai Guoyu Wu Xiaolin Qi Deshi Dong Xufeng Tao Tags: Review Source Type: research
Epigallocatechin Gallate Protects Diabetes Mellitus Rats Complicated with Cardiomyopathy through TGF- β1/JNK Signaling Pathway
CONCLUSION: The results demonstrated that EGCG could improve STZ-induced diabetic complication, i.e., myocardial fibrosis, in diabetic rats, and protect their heart through TGF-β1/JNK signaling pathway.PMID:36173051 | DOI:10.2174/1381612828666220902115437 (Source: Cancer Control)
Source: Cancer Control - September 29, 2022 Category: Cancer & Oncology Authors: Liuming Gui Fengxian Wang Xiangka Hu Xiaojuan Liu He Yang Zeng Xiao Rui Cai Mu Shuang Qi Chunmei Dai Source Type: research
Epigallocatechin Gallate Protects Diabetes Mellitus Rats Complicated with Cardiomyopathy through TGF- β1/JNK Signaling Pathway
CONCLUSION: The results demonstrated that EGCG could improve STZ-induced diabetic complication, i.e., myocardial fibrosis, in diabetic rats, and protect their heart through TGF-β1/JNK signaling pathway.PMID:36173051 | DOI:10.2174/1381612828666220902115437 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 29, 2022 Category: Drugs & Pharmacology Authors: Liuming Gui Fengxian Wang Xiangka Hu Xiaojuan Liu He Yang Zeng Xiao Rui Cai Mu Shuang Qi Chunmei Dai Source Type: research
Epigallocatechin Gallate Protects Diabetes Mellitus Rats Complicated with Cardiomyopathy through TGF- β1/JNK Signaling Pathway
CONCLUSION: The results demonstrated that EGCG could improve STZ-induced diabetic complication, i.e., myocardial fibrosis, in diabetic rats, and protect their heart through TGF-β1/JNK signaling pathway.PMID:36173051 | DOI:10.2174/1381612828666220902115437 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 29, 2022 Category: Drugs & Pharmacology Authors: Liuming Gui Fengxian Wang Xiangka Hu Xiaojuan Liu He Yang Zeng Xiao Rui Cai Mu Shuang Qi Chunmei Dai Source Type: research
The Effects and Mechanisms of Sennoside A on Inducing Cytotoxicity, Apoptosis, and Inhibiting Metastasis in Human Chondrosarcoma Cells
Evid Based Complement Alternat Med. 2022 Aug 31;2022:8063497. doi: 10.1155/2022/8063497. eCollection 2022.ABSTRACTCurrently, developing therapeutic strategies for chondrosarcoma (CS) remains important. Sennoside A (SA), a dianthrone glycoside from Senna and Rhubarb, is widely used as an irritant laxative, weight-loss agent, or dietary supplement, which possesses various bioactive properties such as laxative, antiobesity, and hypoglycemic activities. For the first time, our results suggested that cell proliferation and metastasis were inhibited by SA in CS SW1353 cells. SA induced cell growth arrest by inhibiting cell proli...
Source: Evidence-based Complementary and Alternative Medicine - September 12, 2022 Category: Complementary Medicine Authors: Jiamei Le Houlin Ji Peixian Pi Kaijie Chen Xuefeng Gu Yujie Ma Yi Fu Yongning Sun Xiaoxiao Zhou Hailong Wu Source Type: research
Emodin lows NPC1L1-mediated cholesterol absorption as an uncompetitive inhibitor
Bioorg Med Chem Lett. 2022 Sep 2:128974. doi: 10.1016/j.bmcl.2022.128974. Online ahead of print.ABSTRACTEmodin (EM) is one of the active components of the traditional Chinese medicine rhubarb, and there is evidence of its hypolipidemic activity, though the exact mechanism is unknown. NPC1L1 is a key protein in human cholesterol uptake that is primarily expressed in hepatocytes and gastrointestinal epithelial cells. Our findings suggest that rhodopsin inhibits cellular cholesterol uptake by influencing NPC1L1 cholesterol transport. The results showed that NBD-cholesterol uptake in human HepG2 cells was 27%, 31.3%, 33.6%, 41...
Source: Bioorganic and Medicinal Chemistry Letters - September 5, 2022 Category: Chemistry Authors: Jingsen Meng Jiazhen Xu Shanbo Yang Wenjing Liu Jun Zeng Lingyu Shi Jing Chang Renshuai Zhang Dongming Xing Source Type: research
Mechanism of combined treatment of rhein and emodin in Rhubarb for ulcerative colitis
This study aimed to explore the efficacy and mechanism of combined rhein and emodin in the treatment of ulcerative colitis(UC) from the aspects of network pharmacology, animal inflammation improvement and molecular mechanism. Network pharmacology predicted that combined rhein and emodin acted on 52 potential targets, mainly participating in signaling pathways such as cancer, PI3 K/AKT, microRNAs in cancer and apoptosis. PI3 K/AKT signaling pathway has been reported to be closely related to UC, and the optimal candidate pathway for combined therapy. The UC mice model was established by dextran sodium sulfate, and then the m...
Source: Cancer Control - September 1, 2022 Category: Cancer & Oncology Authors: Fei Gao Hui-Yun Zhong Ke-Xi Chen Ling-Ling Dong Mei-Si Lin Hong-Ling DU Source Type: research
Network pharmacology approach to investigate the multitarget mechanisms of Zhishi Rhubarb Soup on acute cerebral infarction
CONCLUSIONS: This study demonstrated that ZRS improved cerebral ischaemic injury by inhibiting neuroinflammation partly via the AGE-RAGE signalling pathway. It provides a theoretical basis for the clinical application of ZRS in the treatment of ACI.PMID:35938510 | DOI:10.1080/13880209.2022.2103718 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 8, 2022 Category: Drugs & Pharmacology Authors: Yuejia Shao Yue Zhang Rongrong Wu Lurui Dou Fengjiao Cao Yuqing Yan Yuming Tang Chi Huang Yang Zhao Jinghua Zhang Source Type: research
Chrysophanol postconditioning attenuated cerebral ischemia-reperfusion injury induced NLRP3-related pyroptosis in a TRAF6-dependent manner
Exp Neurol. 2022 Aug 3:114197. doi: 10.1016/j.expneurol.2022.114197. Online ahead of print.ABSTRACTIndividuals who suffer from post-CA (cardiac arrest) brain injury experience higher mortality and more severe functional disability. Neuroinflammation has been identified as a vital factor in cerebral ischemia-reperfusion injury (CIRI) following CA. Pyroptosis induces neuronal death by triggering an excessive inflammatory injury. Chrysophanol possesses robust anti-inflammatory features, and it is protective against CIRI. The purpose of this research was to assess the effect of Chrysophanol postconditioning on CIRI-induced pyr...
Source: Experimental Neurology - August 6, 2022 Category: Neurology Authors: Pingping Xia Murat Marjan Zhuoyi Liu Wanqing Zhou Qian Zhang Chen Cheng Minxi Zhao Yuanyuan Tao Zhihua Wang Zhi Ye Source Type: research
Chrysophanol postconditioning attenuated cerebral ischemia-reperfusion injury induced NLRP3-related pyroptosis in a TRAF6-dependent manner
Exp Neurol. 2022 Aug 3:114197. doi: 10.1016/j.expneurol.2022.114197. Online ahead of print.ABSTRACTIndividuals who suffer from post-CA (cardiac arrest) brain injury experience higher mortality and more severe functional disability. Neuroinflammation has been identified as a vital factor in cerebral ischemia-reperfusion injury (CIRI) following CA. Pyroptosis induces neuronal death by triggering an excessive inflammatory injury. Chrysophanol possesses robust anti-inflammatory features, and it is protective against CIRI. The purpose of this research was to assess the effect of Chrysophanol postconditioning on CIRI-induced pyr...
Source: Experimental Neurology - August 6, 2022 Category: Neurology Authors: Pingping Xia Murat Marjan Zhuoyi Liu Wanqing Zhou Qian Zhang Chen Cheng Minxi Zhao Yuanyuan Tao Zhihua Wang Zhi Ye Source Type: research
Chrysophanol postconditioning attenuated cerebral ischemia-reperfusion injury induced NLRP3-related pyroptosis in a TRAF6-dependent manner
Exp Neurol. 2022 Aug 3:114197. doi: 10.1016/j.expneurol.2022.114197. Online ahead of print.ABSTRACTIndividuals who suffer from post-CA (cardiac arrest) brain injury experience higher mortality and more severe functional disability. Neuroinflammation has been identified as a vital factor in cerebral ischemia-reperfusion injury (CIRI) following CA. Pyroptosis induces neuronal death by triggering an excessive inflammatory injury. Chrysophanol possesses robust anti-inflammatory features, and it is protective against CIRI. The purpose of this research was to assess the effect of Chrysophanol postconditioning on CIRI-induced pyr...
Source: Experimental Neurology - August 6, 2022 Category: Neurology Authors: Pingping Xia Murat Marjan Zhuoyi Liu Wanqing Zhou Qian Zhang Chen Cheng Minxi Zhao Yuanyuan Tao Zhihua Wang Zhi Ye Source Type: research
