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Underlying beneficial effects of Rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism
Conclusion: This thesis has provided insight that rhubarb extract promoted the flexibility of collagen fiber, reduced pro-inflammatory cytokines, enhanced anti-inflammatory cytokines, and maintained gut microflora balance with potential impacts on the fatty acid and polyamine metabolism. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 5, 2022 Category: Drugs & Pharmacology Source Type: research

A comprehensive review of emodin in fibrosis treatment
Fitoterapia. 2022 Nov 24:105358. doi: 10.1016/j.fitote.2022.105358. Online ahead of print.ABSTRACTEmodin is the main pharmacodynamic components of rhubarb, with significant pharmacological effects and clinical efficacy.Emodin has a variety of therapy effects, such as anti-cancer, anti-fibrosis effects, and is widely used to treat encephalitis, diabetic cataract and organ fibrosis. Several studies have shown that emodin has a good treatment effect on organ fibrosis, but the mechanism is complex. Moreover, the evidence of some studies is conflicting and confusing. This paper reviewed the mechanism, pharmacokinetics and toxic...
Source: Fitoterapia - November 27, 2022 Category: Biochemistry Authors: None HaoShang Xinhua Jia Huaman Liu Xinyue Zhang Yumeng Shao Source Type: research

Sishen Pill Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis with Spleen-Kidney Yang Deficiency Syndromes: Role of Gut Microbiota, Fecal Metabolites, Inflammatory Dendritic Cells, and TLR4/NF- κ B Pathway
Evid Based Complement Alternat Med. 2022 Oct 3;2022:6132289. doi: 10.1155/2022/6132289. eCollection 2022.ABSTRACTSishen pill (SSP) is an old Chinese medicine used to treat colitis with spleen-kidney-yang deficiency (SKYD) syndromes. However, its exact mechanism of action has not yet been fully elucidated. The aim of this study was to evaluate the effects and potential mechanisms of SSP on colitis with SKYD syndromes in mice. Colitis with SKYD syndromes was induced by rhubarb, hydrocortisone, and dextran sulfate sodium (DSS), and treatment was provided with SSP. Flow cytometry was performed to examine the inflammatory dendr...
Source: Evidence-based Complementary and Alternative Medicine - October 31, 2022 Category: Complementary Medicine Authors: Wei Ge Bu-Gao Zhou You-Bao Zhong Su-Qing Liu Jia-Qi Huang Wang-Yuan Yuan Chang-Ying Xie Duan-Yong Liu Hai-Yan Wang Zheng-Yun Zuo Source Type: research

Effects of aloe-emodin on alveolar bone in Porphyromonas gingivalis -induced periodontitis rat model: a pilot study
CONCLUSIONS: AE decreases alveolar bone loss and periodontal inflammation, suggesting that this natural anthraquinone has potential value as a novel therapeutic agent against periodontal disease.PMID:36302645 | DOI:10.5051/jpis.2104060203 (Source: Journal of Periodontal and Implant Science)
Source: Journal of Periodontal and Implant Science - October 27, 2022 Category: Dentistry Authors: Ming Yang Saroj K Shrestha Yunjo Soh Seok-Mo Heo Source Type: research

Effects of aloe-emodin on alveolar bone in Porphyromonas gingivalis -induced periodontitis rat model: a pilot study
CONCLUSIONS: AE decreases alveolar bone loss and periodontal inflammation, suggesting that this natural anthraquinone has potential value as a novel therapeutic agent against periodontal disease.PMID:36302645 | PMC:PMC9614176 | DOI:10.5051/jpis.2104060203 (Source: Journal of Periodontal and Implant Science)
Source: Journal of Periodontal and Implant Science - October 27, 2022 Category: Dentistry Authors: Ming Yang Saroj K Shrestha Yunjo Soh Seok-Mo Heo Source Type: research