Targeting intestinal flora and its metabolism to explore the laxative effects of rhubarb
In conclusion, the amelioration of rhubarb in constipation might modulate the intestinal microflora and its metabolism. Moreover, the application of fecal metabolomics could provide a new strategy to uncover the mechanism of herbal medicines.Key points• Rhubarb could significantly improve gut microbiota disorder in constipation rats.• Rhubarb could markedly modulate the fecal metabolite profile of constipated rats.PMID:35129656 | DOI:10.1007/s00253-022-11813-5 (Source: Applied Microbiology and Biotechnology)
Source: Applied Microbiology and Biotechnology - February 7, 2022 Category: Microbiology Authors: Lei Yang Yue Wan Wenwen Li Chen Liu Hui-Fang Li Zhiling Dong Ke Zhu Shu Jiang Erxin Shang Dawei Qian Jinao Duan Source Type: research
Rhubarb Enema Increasing Short-Chain Fatty Acids that Improves the Intestinal Barrier Disruption in CKD May Be Related to the Regulation of Gut Dysbiosis
This study indicated that rhubarb enema can improve the intestinal barrier damage of 5/6 nephrectomy model rats and improve CKD, which may be related to the regulation of short-chain fatty acid-producing gut microbiota.PMID:35097110 | PMC:PMC8794667 | DOI:10.1155/2022/1896781 (Source: Biomed Res)
Source: Biomed Res - January 31, 2022 Category: Research Authors: Chunlan Ji Fuhua Lu Yuchi Wu Zhaoyu Lu Yenan Mo Lijuan Han Qizhan Lin Xusheng Liu Chuan Zou Source Type: research
Rhubarb Enema Increasing Short-Chain Fatty Acids that Improves the Intestinal Barrier Disruption in CKD May Be Related to the Regulation of Gut Dysbiosis
This study indicated that rhubarb enema can improve the intestinal barrier damage of 5/6 nephrectomy model rats and improve CKD, which may be related to the regulation of short-chain fatty acid-producing gut microbiota.PMID:35097110 | PMC:PMC8794667 | DOI:10.1155/2022/1896781 (Source: Biomed Res)
Source: Biomed Res - January 31, 2022 Category: Research Authors: Chunlan Ji Fuhua Lu Yuchi Wu Zhaoyu Lu Yenan Mo Lijuan Han Qizhan Lin Xusheng Liu Chuan Zou Source Type: research
Epigenetic changes in inflammatory genes and the protective effect of cooked rhubarb on pancreatic tissue of rats with chronic alcohol exposure
In this study, we investigated whether chronic exposure to alcohol can alter inflammatory gene expression and the epigenetic regulation effect of cooked rhubarb in the pancreatic tissue of rats. First, changes in inflammatory cytokine DNA methylation (IL-10, IL-1α, TNF-α, NF-κB and TGF-β) were detected in pancreatic tissue of Sprague-Dawley rats with varying alcohol exposure times (4, 6, 8, or 12 weeks), and then with varying doses of cooked rhubarb treatment (3, 6, or 12 g/day). DNA methylation levels, related RNA concentrations and protein expression of specific inflammatory cytokines, and histopathological score wer...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 22, 2022 Category: Drugs & Pharmacology Authors: Xianlin Zhao Shifeng Zhu Juan Li Dan Long Meihua Wan Wenfu Tang Source Type: research
Mechanistic insights into the use of rhubarb in diabetic kidney disease treatment using network pharmacology
In this study, we predicted the core active compounds of rhubarb used in the treatment of diabetic kidney disease (DKD) and the related core gene targets and pathways using network pharmacological approaches.
The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was used to identify active compounds of rhubarb. PharmMapper was used to predict the gene targets of active compounds, which were subsequently provided a standard nomenclature using the UniProt database. In addition, DKD-related target genes were predicted using GeneCards, Online Mendelian Inheritance in Man, and Therapeutic Targe...
Source: Medicine - January 7, 2022 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Safety of jidabokuippo administration based on adverse event rate
ConclusionThe adverse event rate associated with JDI use was low and onset was relatively rapid. We can further reduce this adverse event rate by paying attention to the pharmacological action of rhubarb rhizome andGlycyrrhiza root. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - January 5, 2022 Category: Complementary Medicine Authors: Toshiharu Kitamura,
Hajime Nakae,
Yasuhito Irie,
Kasumi Satoh,
Nobuhisa Hirasawa,
Koumei Kameyama,
Yuya Suzuki,
Kyohei Maeno,
Kenji Yoshida,
Manabu Okuyama Tags: ORIGINAL ARTICLE Source Type: research
Emodin ameliorates antioxidant capacity and exerts neuroprotective effect via PKM2-mediated Nrf2 transactivation
Food Chem Toxicol. 2021 Dec 28:112790. doi: 10.1016/j.fct.2021.112790. Online ahead of print.ABSTRACTPyruvate kinase M2 (PKM2) is overexpressed in neuronal cells. However, there are few studies on the involvement of PKM2 modulators in neurodegenerative diseases. Emodin, a dominating anthraquinone derivative extracting from the rhizome of rhubarb, has received expanding consideration due to its pharmacological properties. Our data reveal that emodin could resist hydrogen peroxide- or 6-hydroxydopamine-mediated mitochondrial fission and apoptosis in PC12 cells (a neuron-like rat pheochromocytoma cell line). Notably, emodin a...
Source: Food and Chemical Toxicology - December 31, 2021 Category: Food Science Authors: Zhenjiang Ding Hong Hong Da Alsiddig Osama Junmin Xi Yanan Hou Jianguo Fang Source Type: research
A systematic comparison of the effect of topically applied anthraquinone aglycones to relieve psoriasiform lesion: The evaluation of percutaneous absorption and anti-inflammatory potency
Biomed Pharmacother. 2022 Jan;145:112482. doi: 10.1016/j.biopha.2021.112482. Epub 2021 Dec 3.ABSTRACTThe anthraquinones derived from rhubarb are reported to have anti-inflammatory activity. The present study aimed to assess the topical application of rhubarb anthraquinone aglycones for psoriasis treatment. The antipsoriatic effect of five anthraquinones, including aloe-emodin, rhein, emodin, physcion, and chrysophanol, was compared to elucidate a structure-permeation relationship. Molecular modeling was employed to determine the physicochemical properties. Both macrophages (differentiated THP-1) and keratinocytes (HaCaT) w...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 17, 2021 Category: Drugs & Pharmacology Authors: Chwan-Fwu Lin Shih-Yi Chuang Tse-Hung Huang Thi My Huyen Nguyen Pei-Wen Wang Ahmed Alalaiwe Jia-You Fang Source Type: research
A systematic comparison of the effect of topically applied anthraquinone aglycones to relieve psoriasiform lesion: The evaluation of percutaneous absorption and anti-inflammatory potency
Biomed Pharmacother. 2022 Jan;145:112482. doi: 10.1016/j.biopha.2021.112482. Epub 2021 Dec 3.ABSTRACTThe anthraquinones derived from rhubarb are reported to have anti-inflammatory activity. The present study aimed to assess the topical application of rhubarb anthraquinone aglycones for psoriasis treatment. The antipsoriatic effect of five anthraquinones, including aloe-emodin, rhein, emodin, physcion, and chrysophanol, was compared to elucidate a structure-permeation relationship. Molecular modeling was employed to determine the physicochemical properties. Both macrophages (differentiated THP-1) and keratinocytes (HaCaT) w...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 17, 2021 Category: Drugs & Pharmacology Authors: Chwan-Fwu Lin Shih-Yi Chuang Tse-Hung Huang Thi My Huyen Nguyen Pei-Wen Wang Ahmed Alalaiwe Jia-You Fang Source Type: research
Rheum tanguticum Alleviates Cognitive Impairment in APP/PS1 Mice by Regulating Drug-Responsive Bacteria and Their Corresponding Microbial Metabolites
Drugs targeting intestinal bacteria have shown great efficacy for alleviating symptoms of Alzheimer’s disease (AD), and microbial metabolites are important messengers. Our previous work indicated that Rheum tanguticum effectively improved cognitive function and reshaped the gut microbial homeostasis in AD rats. However, its therapeutic mechanisms remain unclear. Herein, this study aimed to elaborate the mechanisms of rhubarb for the treatment of AD by identifying effective metabolites associated with rhubarb-responsive bacteria. The results found that rhubarb reduced hippocampal inflammation and neuronal damage in APP/PS...
Source: Frontiers in Pharmacology - December 15, 2021 Category: Drugs & Pharmacology Source Type: research
Rhubarb Enema Decreases Circulating Trimethylamine N-Oxide Level and Improves Renal Fibrosis Accompanied With Gut Microbiota Change in Chronic Kidney Disease Rats
Conclusion: Rhubarb enema decreases circulating TMAO level and improves renal fibrosis in 5/6Nx CKD rats, which may be related to the regulation of intestinal microbial community. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 13, 2021 Category: Drugs & Pharmacology Source Type: research
Rhubarb hydroxyanthraquinones act as antiobesity agents to inhibit adipogenesis and enhance lipolysis
This study evaluated and compared the lipid-lowering activity of five rhubarb hydroxyanthraquinones (HAQs), including chrysophanol, aloe emodin, emodin, physcion, and rhein, aiming to identify candidate compounds for obesity treatment. Examination of the antiobesity effects of HAQs in 3T3-L1 adipocytes and high-fat diet (HFD)-induced obese rats showed that these anthraquinone compounds inhibited lipid accumulation in 3T3-L1 cells before and after differentiation. Emodin and rhein showed greater inhibition than the other compounds; dosage at 50 μM reduced intracellular triglyceride (TG) by about 30% in the differentiated a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 10, 2021 Category: Drugs & Pharmacology Authors: Jia-You Fang Tse-Hung Huang Wei-Jhang Chen Ibrahim A Aljuffali Ching-Yun Hsu Source Type: research
Astragalus & ndash;Saffron & ndash;Rhubarb Mixture Delays the Progress of Diabetic Nephropathy in db/db Mice
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - November 30, 2021 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Comparative Evidence for Intrahepatic Cholestasis of Pregnancy Treatment With Traditional Chinese Medicine Therapy: A Network Meta-Analysis
Conclusion: Overall, the combined use of Chinese prescriptions or patent medicine with UDCA was generally better than UDCA used alone. The dose of IP-f might be a beneficial therapeutic method for the clinical medication of ICP.Clinical Trail Registration:https://www.crd.york.ac.uk/, identifier CRD42020188831. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 30, 2021 Category: Drugs & Pharmacology Source Type: research
Inclusion of abandoned rhubarb stalk enhanced anaerobic fermentation of alfalfa on the Qinghai Tibetan Plateau
Bioresour Technol. 2021 Nov 19:126347. doi: 10.1016/j.biortech.2021.126347. Online ahead of print.ABSTRACTTo investigate the effects of lactic acid bacteria inoculant (LI) and abandoned rhubarb stalk (RS) on the anaerobic fermentation and bacterial community of alfalfa on the Qinghai Tibetan Plateau, the alfalfa was harvested and ensiled without (control) or with LI and RS at ambient temperature (5∼15℃) for 90 days. Addition of RS at ensiling increased (P<0.05) lactate, acetate and propionate contents, and decreased (P<0.05) the final pH value as compared with control. Addition of RS increased (P<0.05) the bac...
Source: Bioresource Technology - November 22, 2021 Category: Biotechnology Authors: Ping Li Wenji Zhao Lijun Yan Liangyin Chen Yulian Chen Wenlong Gou Minghong You Qiming Cheng Chao Chen Source Type: research
