< em > Rheum rhaponticum < /em > and < em > Rheum rhabarbarum < /em > Extracts as Modulators of Endothelial Cell Inflammatory Response
This study aimed to evaluate the anti-inflammatory potential of rhubarb extracts isolated from petioles and underground organs of Rheum rhabarbarum L. (garden rhubarb) and R. rhaponticum L. (rhapontic rhubarb) as well as two stilbenoids, typically found in these plants, i.e., rhapontigenin (RHPG) and its glycoside, rhaponticin (RHPT).METHODS: Analysis of the anti-inflammatory effects of the indicated rhubarb-derived substances involved different aspects of the endothelial cells' (HUVECs) response: release of the inflammatory mediators; cyclooxygenase (COX-2) and 5-lipoxygenase (5-LOX) expression as well as the recruitment ...
Source: Atherosclerosis - February 25, 2023 Category: Cardiology Authors: Oleksandra Liudvytska Micha ł B Ponczek Oskar Ciesielski Justyna Krzy żanowska-Kowalczyk Mariusz Kowalczyk Aneta Balcerczyk Joanna Kolodziejczyk-Czepas Source Type: research
< em > Rheum rhaponticum < /em > and < em > Rheum rhabarbarum < /em > Extracts as Modulators of Endothelial Cell Inflammatory Response
This study aimed to evaluate the anti-inflammatory potential of rhubarb extracts isolated from petioles and underground organs of Rheum rhabarbarum L. (garden rhubarb) and R. rhaponticum L. (rhapontic rhubarb) as well as two stilbenoids, typically found in these plants, i.e., rhapontigenin (RHPG) and its glycoside, rhaponticin (RHPT).METHODS: Analysis of the anti-inflammatory effects of the indicated rhubarb-derived substances involved different aspects of the endothelial cells' (HUVECs) response: release of the inflammatory mediators; cyclooxygenase (COX-2) and 5-lipoxygenase (5-LOX) expression as well as the recruitment ...
Source: Atherosclerosis - February 25, 2023 Category: Cardiology Authors: Oleksandra Liudvytska Micha ł B Ponczek Oskar Ciesielski Justyna Krzy żanowska-Kowalczyk Mariusz Kowalczyk Aneta Balcerczyk Joanna Kolodziejczyk-Czepas Source Type: research
Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota
Volume 15, Issue 1, January-December 2023 . (Source: Gut Microbes)
Source: Gut Microbes - February 21, 2023 Category: Microbiology Authors: Marion R égnier Matthias Van Hul Martin Roumain Adrien Paquot Alice de Wouters d ’Oplinter Francesco Suriano Amandine Everard Nathalie M. Delzenne Giulio G. Muccioli Patrice D. Cani Source Type: research
Investigating the chemical profile of Rheum lhasaense and its main ingredient of piceatannol-3'-O- β-D-glucopyranoside on ameliorating cognitive impairment
In conclusion, our results demonstrated that PG mitigated scopolamine-induced cognitive dysfunction in mice by targeting the BACE1-MMP3/9 pathway, and PG might be a promising mild AD drug candidate.PMID:36774724 | DOI:10.1016/j.biopha.2023.114394 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 12, 2023 Category: Drugs & Pharmacology Authors: Yue Wang Qing Liu Qiuyue Lv Kailin Yang Xinyan Wu Yaping Zheng Peigen Xiao Baoping Jiang Chunnian He Source Type: research
Nephroprotective and nephrotoxic effects of Rhubarb and their molecular mechanisms
Biomed Pharmacother. 2023 Jan 28;160:114297. doi: 10.1016/j.biopha.2023.114297. Online ahead of print.ABSTRACTRhubarb, in the form of a traditional Chinese medicine, is used in the treatment of chronic kidney disease (CKD). Previous studies have demonstrated that Rhubarb possesses a good nephroprotective effect, which primarily protects the kidneys from fibrosis, oxidation, inflammation, autophagy, and apoptosis. However, studies have shown that the long-term inappropriate use of Rhubarb may cause damage to renal function. Therefore, how to correctly understand and scientifically evaluate the pharmacodynamics and toxicity ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 30, 2023 Category: Drugs & Pharmacology Authors: Fang Zhang Rui Wu Yanfang Liu Shu Dai Xinyan Xue Yunxia Li Xiaohong Gong Source Type: research
Nephroprotective and nephrotoxic effects of Rhubarb and their molecular mechanisms
Biomed Pharmacother. 2023 Jan 28;160:114297. doi: 10.1016/j.biopha.2023.114297. Online ahead of print.ABSTRACTRhubarb, in the form of a traditional Chinese medicine, is used in the treatment of chronic kidney disease (CKD). Previous studies have demonstrated that Rhubarb possesses a good nephroprotective effect, which primarily protects the kidneys from fibrosis, oxidation, inflammation, autophagy, and apoptosis. However, studies have shown that the long-term inappropriate use of Rhubarb may cause damage to renal function. Therefore, how to correctly understand and scientifically evaluate the pharmacodynamics and toxicity ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 30, 2023 Category: Drugs & Pharmacology Authors: Fang Zhang Rui Wu Yanfang Liu Shu Dai Xinyan Xue Yunxia Li Xiaohong Gong Source Type: research
Physcion prevents high-fat diet-induced endothelial dysfunction by inhibiting oxidative stress and endoplasmic reticulum stress pathways
Eur J Pharmacol. 2023 Jan 26:175554. doi: 10.1016/j.ejphar.2023.175554. Online ahead of print.ABSTRACTHigh-fat diet (HFD)-induced obesity leads endothelial dysfunction and contributes to cardiovascular diseases. Palmitic acid (PA), a free fatty acid, is the main component of dietary saturated fat. Physcion, a chemical ingredient from Rhubarb, has been shown anti-hypertensive, anti-bacteria, and anti-tumor properties. However, the effects of physcion on endothelial dysfunction under HFD-induced obesity have not been reported. The purpose of the present study was to define the protective effect of physcion on HFD-induced end...
Source: European Journal of Pharmacology - January 29, 2023 Category: Drugs & Pharmacology Authors: Yu-Hao Wang Ya-Ping Liu Jia-Quan Zhu Guang Hai Zhou Feng Zhang Qi An Jie Yang Kyung Woo Cho Song Nan Jin Jin Fu Wen Source Type: research
Physcion prevents high-fat diet-induced endothelial dysfunction by inhibiting oxidative stress and endoplasmic reticulum stress pathways
Eur J Pharmacol. 2023 Jan 26:175554. doi: 10.1016/j.ejphar.2023.175554. Online ahead of print.ABSTRACTHigh-fat diet (HFD)-induced obesity leads endothelial dysfunction and contributes to cardiovascular diseases. Palmitic acid (PA), a free fatty acid, is the main component of dietary saturated fat. Physcion, a chemical ingredient from Rhubarb, has been shown anti-hypertensive, anti-bacteria, and anti-tumor properties. However, the effects of physcion on endothelial dysfunction under HFD-induced obesity have not been reported. The purpose of the present study was to define the protective effect of physcion on HFD-induced end...
Source: European Journal of Pharmacology - January 29, 2023 Category: Drugs & Pharmacology Authors: Yu-Hao Wang Ya-Ping Liu Jia-Quan Zhu Guang Hai Zhou Feng Zhang Qi An Jie Yang Kyung Woo Cho Song Nan Jin Jin Fu Wen Source Type: research
Evaluation of two laboratory model methods for diarrheal irritable bowel syndrome
CONCLUSION: In conclusion, restraint stress combined with chemical stimulation can mimic the pathological state of diarrhoea symptoms, visceral hypersensitivity, reduced intestinal mucosal barrier permeability, immune regulatory dysfunction and dysbiosis in IBS-D patients. However, herbs with antibacterial effects such as rhubarb and senna, for example, are not suitable as the first choice for chemical stimulation, as they may lead to a decrease in harmful bacteria and an increase in beneficial bacteria in the intestinal fraction and do not perfectly mimic the imbalanced state of intestinal flora in IBS-D patients, while r...
Source: Molecular Medicine - January 12, 2023 Category: Molecular Biology Authors: Qian Chen Hua Zhang Chang-Yue Sun Qing-Ying He Rui-Rong Zhang Bin-Fei Luo Zi-Hao Zhou Xiao-Fan Chen Source Type: research
Evaluation of two laboratory model methods for diarrheal irritable bowel syndrome
CONCLUSION: In conclusion, restraint stress combined with chemical stimulation can mimic the pathological state of diarrhoea symptoms, visceral hypersensitivity, reduced intestinal mucosal barrier permeability, immune regulatory dysfunction and dysbiosis in IBS-D patients. However, herbs with antibacterial effects such as rhubarb and senna, for example, are not suitable as the first choice for chemical stimulation, as they may lead to a decrease in harmful bacteria and an increase in beneficial bacteria in the intestinal fraction and do not perfectly mimic the imbalanced state of intestinal flora in IBS-D patients, while r...
Source: Molecular Medicine - January 12, 2023 Category: Molecular Biology Authors: Qian Chen Hua Zhang Chang-Yue Sun Qing-Ying He Rui-Rong Zhang Bin-Fei Luo Zi-Hao Zhou Xiao-Fan Chen Source Type: research
Chrysophanol prevents IL-1 β-Induced inflammation and ECM degradation in Osteoarthritis via the Sirt6/NF-κB and Nrf2/NF-κB axis
In this study, chrysophanol inhibited IL-1β -induced expression of ADAMTS-4, MMP13, COX-2 and iNOS. Meanwhile, it can inhibit aggrecan and collagen degradation in osteoarthritic chondrocytes induced by IL-1β.Further studies depicted that SIRT6 silencing eliminated the chrysophanol effect on IL-1β. The results demonstrated that chrysophanol could stimulate SIRT6 activation and, more importantly, increase SIRT6 levels. We also discovered that chrysophanol might impede the NF-κB pathway of OA mice's chondrocytes induced by IL-1β, which could be because it depends on SIRT6 activation to some extent. It had also been previ...
Source: Biochemical Pharmacology - January 2, 2023 Category: Drugs & Pharmacology Authors: Jiajie Lu Zhimin Miao Yuhan Jiang Weiyi Xia Xian Wang Yifeng Shi Libin Ni Sunlong Li Jian Xiao Sunren Sheng Haiming Jin Source Type: research
Chrysophanol prevents IL-1 β-Induced inflammation and ECM degradation in Osteoarthritis via the Sirt6/NF-κB and Nrf2/NF-κB axis
In this study, chrysophanol inhibited IL-1β -induced expression of ADAMTS-4, MMP13, COX-2 and iNOS. Meanwhile, it can inhibit aggrecan and collagen degradation in osteoarthritic chondrocytes induced by IL-1β.Further studies depicted that SIRT6 silencing eliminated the chrysophanol effect on IL-1β. The results demonstrated that chrysophanol could stimulate SIRT6 activation and, more importantly, increase SIRT6 levels. We also discovered that chrysophanol might impede the NF-κB pathway of OA mice's chondrocytes induced by IL-1β, which could be because it depends on SIRT6 activation to some extent. It had also been previ...
Source: Biochemical Pharmacology - January 2, 2023 Category: Drugs & Pharmacology Authors: Jiajie Lu Zhimin Miao Yuhan Jiang Weiyi Xia Xian Wang Yifeng Shi Libin Ni Sunlong Li Jian Xiao Sunren Sheng Haiming Jin Source Type: research
Emodin attenuates inflammation and demyelination in experimental autoimmune encephalomyelitis
In this study, a rat model of experimental autoimmune encephalomyelitis was established by immune induction to simulate multiple sclerosis, and the rats were intraperitoneally injected with emodin (20 mg/kg/d) from the day of immune induction until they were sacrificed. In this model, the nucleotide-binding domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome and the microglia exacerbated neuroinflammation, playing an important role in the development of multiple sclerosis. In addition, silent information regulator of transcription 1 (SIRT1)/peroxisome proliferator-activated receptor-alpha coactivator...
Source: Cell Research - December 26, 2022 Category: Cytology Authors: Yue-Ran Cui Zhong-Qi Bu Hai-Yang Yu Li-Li Yan Juan Feng Source Type: research
