Evaluation of two laboratory model methods for diarrheal irritable bowel syndrome
CONCLUSION: In conclusion, restraint stress combined with chemical stimulation can mimic the pathological state of diarrhoea symptoms, visceral hypersensitivity, reduced intestinal mucosal barrier permeability, immune regulatory dysfunction and dysbiosis in IBS-D patients. However, herbs with antibacterial effects such as rhubarb and senna, for example, are not suitable as the first choice for chemical stimulation, as they may lead to a decrease in harmful bacteria and an increase in beneficial bacteria in the intestinal fraction and do not perfectly mimic the imbalanced state of intestinal flora in IBS-D patients, while restraint stress may be a key factor in modelling.PMID:36635623 | DOI:10.1186/s10020-022-00599-x
Source: Molecular Medicine - Category: Molecular Biology Authors: Qian Chen Hua Zhang Chang-Yue Sun Qing-Ying He Rui-Rong Zhang Bin-Fei Luo Zi-Hao Zhou Xiao-Fan Chen Source Type: research
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