Diffuse large B-cell lymphoma involving the central nervous system: biologic rationale for targeted therapy
Haematologica. 2023 Sep 14. doi: 10.3324/haematol.2021.278613. Online ahead of print.ABSTRACTDiffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell lymphoma curable even in advanced stages. DLBCL involving the central nervous system (CNS) is more difficult to cure and fewer treatment options exist. Primary CNS lymphoma (PCNSL) refers to aggressive lymphomas confined to the CNS, and are almost always DLBCL. Standard approaches for PCNSL use high-dose methotrexate based combinations as induction therapy and younger patients often receive dose-intensive consolidation. However, dose-intensive therapies are not suitable ...
Source: Haematologica - September 14, 2023 Category: Hematology Authors: Mark Roschewski Daniel J Hodson Source Type: research
Deep learning-based overall survival prediction model in patients with rare cancer: a case study for primary central nervous system lymphoma
ConclusionsAll these findings indicate that T1Gd can improve prognosis predictions of patients with PCNSL. To the best of our knowledge, this is the first time to use DL to explain model patterns in OS classification of patients with PCNSL. Future work would involve collecting more data of patients with PCNSL, or additional retrospective studies on different patient populations with rare diseases, to further promote the clinical role of our model. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - September 12, 2023 Category: Intensive Care Source Type: research
Myelin oligodendrocyte glycoprotein antibody-associated disease preceding primary central nervous system lymphoma: causality or coincidence?
We describe a 49-year-old man who presented progressive headache, dizziness, and unsteady gait with multifocal scattered T2 hyperintensities with contrast enhancement. The serum anti-MOG antibody test was positive, and a brain biopsy showed inflammatory infiltration. Initially, he was diagnosed with MOGAD and his condition improved after corticosteroid therapy. The patient relapsed with exacerbation of symptoms and neuroimaging showed new mass-forming lesions four months later. A second brain biopsy confirmed PCNSL.DiscussionThis is the first report of histologically confirmed successive MOGAD and PCNSL. Our case broadens ...
Source: Neurological Sciences - September 11, 2023 Category: Neurology Source Type: research
A case of primary central nervous system diffuse large B-cell lymphoma
Asian J Surg. 2023 Sep 7:S1015-9584(23)01340-4. doi: 10.1016/j.asjsur.2023.08.165. Online ahead of print.NO ABSTRACTPMID:37689520 | DOI:10.1016/j.asjsur.2023.08.165 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - September 9, 2023 Category: Surgery Authors: Simin Yang Yunbo Shi Jinbei Yu Weimin Yang Source Type: research
A case of primary central nervous system diffuse large B-cell lymphoma
Asian J Surg. 2023 Sep 7:S1015-9584(23)01340-4. doi: 10.1016/j.asjsur.2023.08.165. Online ahead of print.NO ABSTRACTPMID:37689520 | DOI:10.1016/j.asjsur.2023.08.165 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - September 9, 2023 Category: Surgery Authors: Simin Yang Yunbo Shi Jinbei Yu Weimin Yang Source Type: research
Different patterns of failure in two treatment regimens for primary central nervous system lymphoma, a retrospective analysis of 124 cases in Taiwan
AbstractTo explore prognostic factors and outcomes of primary central nervous system lymphoma (PCNSL) of diffuse large B-cell lymphoma (DLBCL) in Taiwan, 124 PCNSL-DLBCL patients (from 1995 to 2021) were retrospectively analyzed. Mainly, two treatment modalities including sandwich chemoradiotherapy and modified MATRix regimen were employed in these patients. Overall survival (OS) was determined by log-rank test and time-dependent Cox analysis. Median OS of all patients was 27.1 months. 47 (37.9%) patients who underwent sandwich chemoradiotherapy had a complete re mission (CR) rate of 87.2%, median OS of 53.9 months, a...
Source: Clinical and Experimental Medicine - September 7, 2023 Category: Research Source Type: research
Achieving imaging and computational reproducibility on multiparametric MRI radiomics features in brain tumor diagnosis: phantom and clinical validation
ConclusionRadiomics features with high reproducibility across multiple sessions, scanners, and computational algorithms were identified, and they showed higher diagnostic performance than non-reproducible radiomics features in the differentiation of glioblastoma from PCNSL.Clinical relevance statementBy identifying the radiomics features showing higher multi-machine reproducibility, our results also demonstrated higher radiomics diagnostic performance in the differentiation of glioblastoma from PCNSL, paving the way for further research designs and clinical application in neuro-oncology.Key Points• Highly reproducible ra...
Source: European Radiology - September 4, 2023 Category: Radiology Source Type: research
Sustained response following BTK inhibitors based treatment in HIV-related primary central nervous system lymphoma: case report
CONCLUSIONS: This report highlights the safety and effectiveness of BTK inhibitors, as well as lenalidomide and PD-1 inhibitor in HIV-related PCNSL patients. Both the new therapeutic approaches and a multidisciplinary team authentically contributed to improved survival outcome among HIV-positive PCNSL patients.PMID:37644480 | DOI:10.1186/s12981-023-00554-8 (Source: Cell Research)
Source: Cell Research - August 29, 2023 Category: Cytology Authors: Ying Zhou Xiaoxue Wang Xuyong Lin Jun Wang Xiaojing Yan Ying Wen Source Type: research
Sustained response following BTK inhibitors based treatment in HIV-related primary central nervous system lymphoma: case report
CONCLUSIONS: This report highlights the safety and effectiveness of BTK inhibitors, as well as lenalidomide and PD-1 inhibitor in HIV-related PCNSL patients. Both the new therapeutic approaches and a multidisciplinary team authentically contributed to improved survival outcome among HIV-positive PCNSL patients.PMID:37644480 | DOI:10.1186/s12981-023-00554-8 (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 29, 2023 Category: Infectious Diseases Authors: Ying Zhou Xiaoxue Wang Xuyong Lin Jun Wang Xiaojing Yan Ying Wen Source Type: research
Sustained response following BTK inhibitors based treatment in HIV-related primary central nervous system lymphoma: case report
CONCLUSIONS: This report highlights the safety and effectiveness of BTK inhibitors, as well as lenalidomide and PD-1 inhibitor in HIV-related PCNSL patients. Both the new therapeutic approaches and a multidisciplinary team authentically contributed to improved survival outcome among HIV-positive PCNSL patients.PMID:37644480 | PMC:PMC10466696 | DOI:10.1186/s12981-023-00554-8 (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 29, 2023 Category: Infectious Diseases Authors: Ying Zhou Xiaoxue Wang Xuyong Lin Jun Wang Xiaojing Yan Ying Wen Source Type: research
Sustained response following BTK inhibitors based treatment in HIV-related primary central nervous system lymphoma: case report
CONCLUSIONS: This report highlights the safety and effectiveness of BTK inhibitors, as well as lenalidomide and PD-1 inhibitor in HIV-related PCNSL patients. Both the new therapeutic approaches and a multidisciplinary team authentically contributed to improved survival outcome among HIV-positive PCNSL patients.PMID:37644480 | PMC:PMC10466696 | DOI:10.1186/s12981-023-00554-8 (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 29, 2023 Category: Infectious Diseases Authors: Ying Zhou Xiaoxue Wang Xuyong Lin Jun Wang Xiaojing Yan Ying Wen Source Type: research
Sustained response following BTK inhibitors based treatment in HIV-related primary central nervous system lymphoma: case report
CONCLUSIONS: This report highlights the safety and effectiveness of BTK inhibitors, as well as lenalidomide and PD-1 inhibitor in HIV-related PCNSL patients. Both the new therapeutic approaches and a multidisciplinary team authentically contributed to improved survival outcome among HIV-positive PCNSL patients.PMID:37644480 | PMC:PMC10466696 | DOI:10.1186/s12981-023-00554-8 (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 29, 2023 Category: Infectious Diseases Authors: Ying Zhou Xiaoxue Wang Xuyong Lin Jun Wang Xiaojing Yan Ying Wen Source Type: research
Sustained response following BTK inhibitors based treatment in HIV-related primary central nervous system lymphoma: case report
Despite increasing effort for treating primary central nervous system lymphoma (PCNSL), the prognosis of human immunodeficiency virus (HIV) -related PCNSL was still unsatisfactory. There is currently a lack of... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - August 29, 2023 Category: Infectious Diseases Authors: Ying Zhou, Xiaoxue Wang, Xuyong Lin, Jun Wang, Xiaojing Yan and Ying Wen Tags: Case Report Source Type: research
Unusual localization and clinical presentation of primary central nervous system extranodal marginal zone B ‑cell lymphoma: A case report
Oncol Lett. 2023 Aug 4;26(3):408. doi: 10.3892/ol.2023.13994. eCollection 2023 Sep.ABSTRACTPrimary central nervous system (CNS) extranodal marginal zone B-cell lymphoma (MZBL) is a rare low-grade non-Hodgkin lymphoma, characterised predominantly by small B cells, plasma cells, monocytoid cells and scattered large immunoblasts. Primary CNS MZBL is a slow-growing tumour that remains localised and is characterised by an excellent clinical prognosis. The present study describes the case of a 48-year-old HIV-negative female patient with a history of head trauma 1 year prior, who presented with worsening neurological symptoms an...
Source: Oncology Letters - August 21, 2023 Category: Cancer & Oncology Authors: Vincenzo Fiorentino Cristina Pizzimenti Francesco Pierconti Maria Lentini Antonio Ieni Maria Caffo Filippo Angileri Giovanni Tuccari Guido Fadda Maurizio Martini Luigi Maria Larocca Source Type: research
