The Pediatric Proton and Photon Therapy Comparison Cohort: Study Design for a Multicenter Retrospective Cohort to Investigate Subsequent Cancers After Pediatric Radiation Therapy
CONCLUSIONS: Our findings will affect clinical practice for pediatric patients with cancer by providing the first large-scale systematic comparison of the risk of subsequent cancers from proton compared with photon therapy.PMID:38047226 | PMC:PMC10692298 | DOI:10.1016/j.adro.2023.101273 (Source: Adv Data)
Source: Adv Data - December 4, 2023 Category: Epidemiology Authors: Amy Berrington de Gonz ález Todd M Gibson Choonsik Lee Paul S Albert Keith T Griffin Cari Meinhold Kitahara Danping Liu Matthew M Mille Jungwook Shin Benjamin V M Bajaj Tristin E Flood Sara L Gallotto Harald Paganetti Safia K Ahmed Bree R Eaton Daniel J Source Type: research
Epileptic seizures in patients with primary central nervous system lymphoma: A systematic review
CONCLUSIONS: Further studies are needed to investigate seizures in larger cohorts of PCNSL, to clarify their prevalence, better characterize them, identify risk factors, analyze survival rates, and make recommendations on AED management. We recommend following general practice guidelines for seizures symptomatic of brain tumors and not to prescribe AED prophylaxis in PCNSL.PMID:38042665 | DOI:10.1016/j.neurol.2023.08.021 (Source: Revue Neurologique)
Source: Revue Neurologique - December 2, 2023 Category: Neurology Authors: O Aboubakr C Houillier S Choquet S Dupont K Hoang-Xuan B Mathon Source Type: research
Primary anaplastic large cell lymphoma arising from central nervous system
AbstractA 22-year-old man presented at the emergency department with progressive headache, vomiting and horizontal diplopia over 2-month period. He also developed blurred vision in his left eye. He complained of loss of appetite for the past 2 months, resulting in a 5-kg weight loss. Examination upon arrival revealed papilledema and bilateral abducens nerve palsy. Motor and sensory functions were intact. Magnetic resonance imaging (MRI) of the brain revealed multiple extra-axial nodular enhancing lesions with size of 5 –10 mm mainly along with both sides of falx cerebri and vasogenic brain oedema (Fig.1). Stereotactic br...
Source: Journal of Hematopathology - December 2, 2023 Category: Pathology Source Type: research
Clonal hematopoiesis with TET2 mutations spawning synchronous primary central nervous system lymphoma and myelodysplastic syndrome
(Source: Annals of Hematology)
Source: Annals of Hematology - December 1, 2023 Category: Hematology Source Type: research
Differentiating primary central nervous system lymphoma from glioblastoma by time-dependent diffusion using oscillating gradient
This study aimed to elucidate the impact of effective diffusion time setting on apparent diffusion coefficient (ADC)-based differentiation between primary central nervous system lymphomas (PCNSLs) and glioblas... (Source: Cancer Imaging)
Source: Cancer Imaging - November 30, 2023 Category: Radiology Authors: Kiyohisa Kamimura, Tsubasa Nakano, Tomohito Hasegawa, Masanori Nakajo, Chihiro Yamada, Yoshiki Kamimura, Kentaro Akune, Fumitaka Ejima, Takuro Ayukawa, Hiroaki Nagano, Koji Takumi, Masatoyo Nakajo, Nayuta Higa, Hajime Yonezawa, Ryosuke Hanaya, Mari Kirish Tags: Research article Source Type: research
Impact of Folinic Acid Dosing on Efficacy and Toxicity of High-Dose Methotrexate in Central Nervous System Lymphoma
CONCLUSION: Our findings suggest that optimizing FA dosing to avoid very high rescue doses may improve treatment outcomes in PCNSL patients receiving HDMTX. Further prospective studies are warranted to validate these findings.PMID:38008594 | DOI:10.1016/j.clml.2023.10.012 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - November 26, 2023 Category: Cancer & Oncology Authors: Arnon Haran Noa Gross Even-Zohar Michal Haran Eyal Lebel Shlomzion Aumann Adir Shaulov Moshe Gatt Boaz Nachmias Source Type: research
Impact of Folinic Acid Dosing on Efficacy and Toxicity of High-Dose Methotrexate in Central Nervous System Lymphoma
CONCLUSION: Our findings suggest that optimizing FA dosing to avoid very high rescue doses may improve treatment outcomes in PCNSL patients receiving HDMTX. Further prospective studies are warranted to validate these findings.PMID:38008594 | DOI:10.1016/j.clml.2023.10.012 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - November 26, 2023 Category: Cancer & Oncology Authors: Arnon Haran Noa Gross Even-Zohar Michal Haran Eyal Lebel Shlomzion Aumann Adir Shaulov Moshe Gatt Boaz Nachmias Source Type: research
Primary breast diffuse large B ‐cell lymphoma in the rituximab era: A retrospective study of the Chinese Southwest Oncology Group
ConclusionCollectively, our results indicate combined modality therapy including rituximab-containing immunochemotherapy and consolidative breast RT is a promising approach for PB-DLBCL, while HD-MTX is useful for preventing CNS relapse. (Source: Cancer Medicine)
Source: Cancer Medicine - November 24, 2023 Category: Cancer & Oncology Authors: Huawei Weng,
Prem Raj Shrestha,
Huangming Hong,
Zegeng Chen,
Le Yu,
Yuyi Yao,
Zhihui Zhang,
Liqun Zou,
Bo Zhu,
Hui Zhou,
Xianling Liu,
Yao Liu,
Hongqiang Guo,
He Huang,
Tongyu Lin Tags: RESEARCH ARTICLE Source Type: research
Cancers, Vol. 15, Pages 5564: Involved-Site Radiation Therapy Enables Effective Disease Control in Parenchymal Low-Grade Primary Cerebral Lymphoma
Conclusions: Our analysis corroborates the results from the literature and demonstrates that parenchymal low-grade PCNSL shows a good response to localized radiation treatment, enabling a favorable outcome while avoiding long-term treatment toxicity. (Source: Cancers)
Source: Cancers - November 24, 2023 Category: Cancer & Oncology Authors: Niklas Benedikt Pepper Michael Oertel Gabriele Reinartz Khaled Elsayad Dominik Alexander Hering Fatih Yalcin Moritz Wildgruber Walter Stummer Georg Lenz Wolfram Klapper Hans Theodor Eich Tags: Article Source Type: research
The ghost tumour revisited. Corticosteroids in primary central nervous system lymphoma: diagnostic, prognostic and therapeutic implications
. (Source: British Journal of Neurosurgery)
Source: British Journal of Neurosurgery - November 24, 2023 Category: Neurosurgery Authors: Alejandra MosteiroJhon A HoyosAbel FerresThomaz TopczewskiAndrea RiveroAlfredo RivasIban AldecoaGabriela Ailen CaballeroRicardo MorcosOlga BalagueJoaquim Ense ñatJose Juan Gonzáleza Department of Neurological Surgery, Hospital Clínic of Barcelona, Barc Source Type: research
Central Nervous System Lymphoma
This article provides a comprehensive overview of the current understanding of CNSL encompassing its epidemiology, pathophysiology, clinical presentation, diagnosis, treatment modalities, and prognosis. Although the main focus is on primary CNS lymphoma (PCNSL), ocular lymphoma, primary leptomeningeal lymphoma, and secondary CNS lymphoma are also discussed. The pathobiology of CNSL involves the infiltration of malignant lymphocytes within the CNS parenchyma or leptomeninges. Various risk factors and immunological mechanisms contribute to its development, including immunodeficiency states, chronic inflammation, and genomic ...
Source: Seminars in Neurology - November 23, 2023 Category: Neurology Authors: Shah, Trusha Venur, Vyshak A. Tags: Review Article Source Type: research
Social cognition and occupational reintegration in primary central nervous system lymphoma long-term survivors: a secondary analysis of a combined data set
. (Source: Journal of Psychosocial Oncology)
Source: Journal of Psychosocial Oncology - November 20, 2023 Category: Cancer & Oncology Authors: Milena PertzSabine SeidelGreta WiemannThomas KowalskiPatrizia Thomaa Department of Medical Psychology and Medical Sociology, Ruhr University Bochum, Bochum, Germanyb Department of Neurology, University Hospital Knappschaftskrankenhaus, Ruhr University Boc Source Type: research
