[Dyslipidemia Secondary to Hypothyroidism and Cholestasis].
We describe the case of a 50-year-old female patient with class II obesity and primary biliary cirrhosis, evaluated for mixed dyslipidemia with poor control (statins and fibrates were being administered) as well as abnormal liver tests. The investigation carried out revealed primary auto-immune hypothyroidism. After normalisation of thyroid function by treatment with levothyroxine, as well as suspending the administration of statins and fibrates, there was an improvement in the lipid profile, although hypercholesterolemia continued. During this time, the patient was diagnosed with diabetes and she re-commenced statin thera...
Source: Acta Medica Portuguesa - March 5, 2020 Category: General Medicine Tags: Acta Med Port Source Type: research
Parkinson's disease accompanied by primary biliary cirrhosis: a case report
No abstract available (Source: Gastroenterology Nursing)
Source: Gastroenterology Nursing - March 1, 2020 Category: Nursing Tags: Departments: Clinical Case Study Source Type: research
Investigation and analysis of HEp 2 indirect immunofluorescence titers and patterns in various liver diseases
ConclusionsThere are differences in ANA positivity among patients with SARD and various liver diseases. Some mixed patterns may provide important evidence for the diagnosis of PBC. Clinicians should pay attention to ANA patterns and titer during the interpretation of this test.Key Points• Defining the clinical relevance of antinuclear antibody (ANA) using indirect immunofluorescence assay in the context of diseases can be an important tool for the clinician in the diagnostic work-up of patients with liver diseases.• The mixed pattern of ANA is majorly found in primary biliary cirrhosis (PBC). ANA patterns including AC-...
Source: Clinical Rheumatology - February 26, 2020 Category: Rheumatology Source Type: research
Mold Exposure and Mitochondrial Antibodies.
Conclusions: The fact that high levels of AMA in the 6 patients were all associated with mold and moisture exposure appears to be significant. Exposure to water- and mold-damaged indoor environments might damage mitochondria and trigger autoimmunity. Long term follow-up is needed to determine what may develop in these patients.
PMID: 32088666 [PubMed - as supplied by publisher] (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 20, 2020 Category: Complementary Medicine Authors: Lieberman A, Curtis L Tags: Altern Ther Health Med Source Type: research
Proteomics characterization of CENP-B epitope in Moroccan scleroderma patients with anti-centromere autoantibodies.
CONCLUSION: Our data showed, for the first time in Morocco, that the Nt-CENPB contains a major epitope for Moroccan SSc patients. These findings could provide additional information that would contribute to improving the diagnosis and management of these patients.
PMID: 32057908 [PubMed - as supplied by publisher] (Source: Immunology Letters)
Source: Immunology Letters - February 10, 2020 Category: Allergy & Immunology Authors: Zian Z, Mechita MB, Hamdouch K, Maamar M, Barakat A, Nourouti NG, El Aouad R, Valdivia MM, Arji N Tags: Immunol Lett Source Type: research
Recurrent panic attack and bilateral hippocampus lesions as main manifestation in an autoimmune encephalitis associated with primary biliary cirrhosis.
PMID: 31929372 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2020 Category: General Medicine Authors: Chen SM, Zhang YF, Liu GH, Li L, Zhang HJ, Zhou L Tags: Chin Med J (Engl) Source Type: research
LCAT protects against Lipoprotein ‐X formation in a murine model of drug‐induced intrahepatic cholestasis
AbstractFamilial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) is a rare genetic disease characterized by low HDL ‐C levels, low plasma cholesterol esterification, and the formation of Lipoprotein‐X (Lp‐X), an abnormal cholesterol‐rich lipoprotein particle. LCAT deficiency causes corneal opacities, normochromic normocytic anemia, and progressive renal disease due to Lp‐X deposition in the glomeruli. R ecombinant LCAT is being investigated as a potential therapy for this disorder. Several hepatic disorders, namely primary biliary cirrhosis, primary sclerosing cholangitis, cholestatic liver disease, ...
Source: Pharmacology Research and Perspectives - December 28, 2019 Category: Drugs & Pharmacology Authors: Marcelo J. A. Amar,
Lita A. Freeman,
Takafumi Nishida,
Maureen L. Sampson,
Milton Pryor,
Boris L. Vaisman,
Edward B. Neufeld,
Sotirios K. Karathanasis,
Alan T. Remaley Tags: ORIGINAL ARTICLE Source Type: research
Hepatopathy of unknown etiology - is liver biopsy a good tool in differential diagnosis?
Conclusions: Liver biopsy - despite the increasing access to new, non-invasive methods - remains a useful method in the differential diagnosis of liver diseases.
PMID: 31749874 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research
The MHC II-CD4 Immunologic Synapse in Alcoholic Hepatitis and Autoimmune Liver Pathology: The Role of Aberrant MHC II in Hepatocytes.
Abstract
The major histocompatibility complex class II (MHC II) - CD4 immunologic synapse is classically described between the T cell receptor of CD4 positive lymphocytes and MHC II on antigen presenting cells. This interaction and others between surrounding costimulatory and checkpoint molecules promotes differentiation of naïve CD4 T lymphocytes into helper T cells subtypes including Th1, Th2, and Th17 that have more tailored immunologic responses. Although MHC II is mainly produced by professional antigen presenting cells, it can be aberrantly produced by other cell types, including hepatocytes in vari...
Source: Am J Pathol - October 24, 2019 Category: Pathology Authors: Lu JG, Ji P, French SW Tags: Am J Pathol Source Type: research
Autoimmunity in women: An eXamination of eXisting models.
Abstract
In Western countries, about 5% of the population is affected by an autoimmune disease; in the United States, up to 23.5 million Americans suffer from autoimmune disorders [1]. Women comprise over 80% of the affected individuals for many autoimmune conditions, including Sjögren's syndrome, systemic sclerosis, Addison's disease, primary biliary cirrhosis, systemic lupus erythematosus (SLE), and autoimmune thyroid diseases like Grave's disease and Hashimoto's thyroiditis [2]. Additionally, the prevalence of rheumatoid arthritis, multiple sclerosis, and Sjögren's syndrome is also skewed towards wome...
Source: Clinical Immunology - October 23, 2019 Category: Allergy & Immunology Authors: Yuen GJ Tags: Clin Immunol Source Type: research
Slit2 signaling contributes to cholestatic fibrosis in mice by activation of hepatic stellate cells.
In conclusion, Slit2 is involved in the activation of HSCs and liver fibrogenesis, highlighting Slit2 as a potential therapeutic target for liver fibrosis.
PMID: 31545977 [PubMed - as supplied by publisher] (Source: Experimental Cell Research)
Source: Experimental Cell Research - September 19, 2019 Category: Cytology Authors: Li C, Yang G, Lin L, Xuan Y, Yan S, Ji X, Song F, Lu M, Lan T Tags: Exp Cell Res Source Type: research
Severe anemia caused by hereditary hemorrhagic telangiectasia in a patient with Sj ögren's syndrome and primary biliary cirrhosis.
Severe anemia caused by hereditary hemorrhagic telangiectasia in a patient with Sjögren's syndrome and primary biliary cirrhosis.
Chin Med J (Engl). 2019 Sep 06;:
Authors: Qin Y, Yin G, Xie QB
PMID: 31503060 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - September 5, 2019 Category: General Medicine Authors: Qin Y, Yin G, Xie QB Tags: Chin Med J (Engl) Source Type: research
A case of hepatic pseudolymphoma in a patient with primary biliary cirrhosis
Hepatic pseudolymphoma is a very rare benign reactive lymphoid hyperplasia associated with autoimmunity and chronic inflammatory liver diseases such as primary biliary cirrhosis and may mimic hepatocellular carcinoma. This diagnosis should be suspected in female with a suspicious single tumor. Close monitoring is needed in view of its premalignant nature. AbstractHepatic pseudolymphoma is a very rare benign reactive lymphoid hyperplasia associated with autoimmunity and chronic inflammatory liver diseases such as primary biliary cirrhosis and may mimic hepatocellular carcinoma. This diagnosis should be suspected in female w...
Source: Clinical Case Reports - August 19, 2019 Category: General Medicine Authors: Masashi Inoue,
Masahiro Tanemura,
Tomio Yuba,
Tatsuya Miyamoto,
Megumi Yamaguchi,
Toshimitsu Irei,
Shingo Seo,
Toshihiro Misumi,
Wataru Shimizu,
Takahisa Suzuki,
Takashi Onoe,
Takeshi Sudo,
Yosuke Shimizu,
Takao Hinoi,
Hirotaka Tashiro Tags: CASE REPORT Source Type: research
Amyotrophic Lateral Sclerosis and Primary Biliary Cirrhosis Overlap Syndrome: Two Cases Report
We present two cases of ALS with PBC to explore the relationship between the two diseases from the immunological and mitochondrial aspects. Further attention should be given to immune-modulating therapy in ALS patients. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - August 13, 2019 Category: Neurology Source Type: research
