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Two decades of research on autoimmune liver disease in Turkey
CONCLUSION: The overall number and quality of AILD-related papers in Turkey are unexpectedly low, although a number of papers have received considerable international recognition. More epidemiologic, prospective, and multicenter research projects are warranted to advance AILD knowledge and to produce high-quality research from Turkey.PMID:33626000 | PMC:PMC7928254 | DOI:10.5152/tjg.2020.19866 (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - February 24, 2021 Category: Gastroenterology Authors: Nurhan Demir Naz ım Ekin Murat Torgutalp Staffan Wahlin Cumali Efe Source Type: research

Antineutrophil cytoplasmic antibody profiles differ according to type of primary sclerosing cholangitis and autoimmune hepatitis
CONCLUSIONS: PSC/IBD+ differed from PSC/IBD- in terms of sex and proteinase 3-ANCA and atypical perinuclear-ANCA reactivity, the latter of which was more frequently detected in type-1 and type-3 AIH than in type-2 AIH. There was no agreement between ANCA patterns and antigenic specificities in IBD and autoimmune liver diseases, which reinforces the need for proteinase-3 and myeloperoxidase antibody testing. (Source: Clinics)
Source: Clinics - February 5, 2021 Category: General Medicine Source Type: research

Primary Biliary Cirrhosis and Granulomatous Hepatitis After Immune Checkpoint Blockade in Patients With Metastatic Melanoma: Report of 2 Cases and Literature Discussion
We present here the case of a 69-year-old man with metastatic melanoma developing a severe primary biliary cirrhosis under pembrolizumab, and of a 52-year-old woman with metastatic melanoma with granulomatous hepatitis in the context of an immune-related multiorgan inflammatory reaction due to ipilimumab and nivolumab. Both cases were in part steroid refractory and required a complex diagnostic assessment and long-term therapeutic management. The liver biopsy was crucial for ensuring a correct diagnosis. Clinicians should be aware of rare liver diseases in the context of increased liver enzymes under immune checkpoint inhi...
Source: Journal of Immunotherapy - February 1, 2021 Category: Allergy & Immunology Tags: Clinical Studies Source Type: research

Hybrid laparoscopic Inokuchi shunt procedure for refractory pleural effusion and ascites associated with primary biliary cirrhosis: a case report
Publication date: Available online 20 January 2021Source: International Journal of Surgery Case ReportsAuthor(s): Ayato Obana, Yoshinobu Sato, Motoi Koyama, Kenta Kitamura, Tatsushi Suwa (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - January 20, 2021 Category: Surgery Source Type: research