Red cell distribution width to platelet ratio for liver fibrosis: A systematic review and meta-analysis of diagnostic accuracy.
Authors: Milas GP, Karageorgiou V, Cholongitas E
Abstract
Introduction: Red cell distribution width to platelet ratio (RPR) may be a useful marker for the evaluation of liver fibrosis in chronic liver disease (CLD). We sought to investigate its value in fibrosis-related outcomes in a meta-analysis of diagnostic accuracy. Areas covered: We searched MEDLINE (1966-2019), Clinicaltrials.gov (2008-2019), Cochrane Central Register of Controlled Trials (CENTRAL) (1999-2019), Google Scholar (2004-2019) and WHO (International Clinical Trials Register Platform) databases using a structured algorithm. The articles we...
Source: Expert Review of Gastroenterology and Hepatology - August 9, 2019 Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Reactive lymphoid hyperplasia of the liver: A case report
Rationale:
Reactive lymphoid hyperplasia (RLH) of the liver is an uncommon benign lesion. It is usually difficult to differentiate from hepatocellular carcinoma (HCC), peripheral-type cholangiocellular carcinoma (CCC), combined HCC-CCC, and liver metastases. On account of its rarity and controversial issues, we report a case report and review the literature to discuss its clinical features, treatments, radiological, and immunohistochemical characteristics.
Patient concerns:
A 54-year-old woman had a history of primary biliary cirrhosis and chronic cholecystitis. She complained of finding a lesion in the right liver du...
Source: Medicine - July 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
[ASAP] Discovery of a Novel Selective Dual Peroxisome Proliferator-Activated Receptor a/d Agonist for the Treatment of Primary Biliary Cirrhosis
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00189 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - June 26, 2019 Category: Chemistry Authors: Zhigan Jiang †, Xing Liu‡, Zhiliang Yuan†, Haiying He*†, Jing Wang†, Xiao Zhang†, Zhen Gong†, Lijuan Hou†, Liang Shen†, Fengxun Guo†, Jiliang Zhang†, Jianhua Wang†, Deming Xu†, Zhuowei Liu‡§, Haijun Li‡§, Xiaoxin Chen*‡§ Source Type: research
Th17/Treg cell level and clinical characteristics of peripheral blood of patients with Sjogren's syndrome complicated with primary biliary cirrhosis
This study aims at analyzing the Th17/Treg cell level and clinical characteristics of the peripheral blood of patients with Sjogren's syndrome (SS) complicated with primary biliary cirrhosis (PBC) so as to deepen the understanding of this disease and seek for its possible onset mechanism.
A retrospective analysis was conducted on the clinical data of 24 patients [8 (33%) males and 16 (67%) females] with SS complicated with primary biliary cirrhosis, 50 patients with primary SS and 93 healthy volunteers. These patients were divided into 3 groups: experimental group (SS+PBC), control group (SS) and healthy group. Then, peri...
Source: Medicine - June 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Polyphenols in the treatment of autoimmune diseases
Publication date: Available online 3 May 2019Source: Autoimmunity ReviewsAuthor(s): Haroon Khan, Antoni Sureda, Tarun Belwal, Sümeyra Çetinkaya, İpek Süntar, Silvia Tejada, Hari Prasad Devkota, Hammad Ullah, Michael AschnerAbstractIn addition to protecting body from infections and diseases, the immune system produces auto-antibodies that can cause complex autoimmune disorders, such as Type I diabetes, primary biliary cirrhosis, rheumatoid arthritis, and multiple sclerosis, to name a few. In such cases, the immune system fails to recognize between foreign agents and its own body cells. Different factors, such as genetic...
Source: Autoimmunity Reviews - May 4, 2019 Category: Allergy & Immunology Source Type: research
