The coronavirus disease 2019 and effect on liver function: a hidden and vital interaction beyond the respiratory system
This study reviews the liver's markers’ characteristics in patients with COVID-19 to achieve novel insights in improving clinical treatment. Liver disease and chronic kidney disease patients are susceptible to COVID-19. There is limited information about the effects of SARS-COV-2 on patients with preexisting liver associated disorders, including chronic hepatitis B virus or hepatitis C virus, primary biliary cirrhosis, nonalcoholic fatty liver disease, and more are yet to be understood. By considering conducted studies in this manner since ACE2 receptors, which are the primary receptors for SRAS-CoV-2, exist on the liver...
Source: Reviews in Medical Microbiology - December 25, 2021 Category: Microbiology Tags: FOCUS ON COVID-19 Source Type: research
Ocular tuberculosis - a case series
Conclusion: We underline the importance of TB suspicion. We report that the majority of treated OTB patients had at least clinical stabilization with antituberculostatic with scarce side effects. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Lopes Figueiredo, C., Silva, M., Fabiano, A., Maia, D., Carvalho, J., Carreira, S., Mourato, T., Nogueira, F., Miguel, A., Cardoso, J., Gomes, C. Tags: Tuberculosis and non-tuberculous mycobacterial diseases Source Type: research
Early histopathologic changes in primary biliary cholangitis: does ‘minimal change’ primary biliary cholangitis exist? A pathologist’s view
Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is an autoimmune, slowly progressive, cholestatic liver disease characterized by nonsuppurative destructive cholangitis, and interlobular bile duct destruction. Necroinflammatory activities of the hepatic parenchyma and limiting plates of milder form along with late liver fibrosis may develop. Serum liver tests include elevated serum alkaline phosphatase along with a positive antimitochondrial antibody (AMA) in nearly 95% of patients. Liver biopsies are an important confirmatory and staging tool and are additionally very helpful when AMA is neg...
Source: European Journal of Gastroenterology and Hepatology - November 5, 2021 Category: Gastroenterology Tags: Reviews Source Type: research
Overlap autoimmune syndrome: primary progressive multiple sclerosis, primary biliary cirrhosis, Raynaud phenomena with digital necrosis
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - November 1, 2021 Category: Neurology Source Type: research
Primary biliary cirrhosis associated with myasthenia gravis after postpartum: a case report
ConclusionsThis case exhibits a rare condition of myasthenia gravis combined with primary biliary cirrhosis postpartum. Given the fluctuation of the immune status during the postpartum period, combined autoimmune diseases need to be taken into account when patients develop clinical symptoms of an autoimmune disease. Therefore, detailed physical and laboratory examination can help to prevent the missed diagnosis of these diseases. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - October 10, 2021 Category: General Medicine Source Type: research
Joint Analysis of Genetic Correlation, Mendelian Randomization and Colocalization Highlights the Bi-Directional Causal Association Between Hypothyroidism and Primary Biliary Cirrhosis
Conclusion: Our results suggest evidence for the bi-directional causal association between hypothyroidism and PBC, which may provide insights into the etiology of hypothyroidism and PBC as well as inform prevention and intervention strategies directed toward both diseases. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - October 4, 2021 Category: Genetics & Stem Cells Source Type: research
Molecules, Vol. 26, Pages 5966: Glyceric Prodrug of Ursodeoxycholic Acid (UDCA): Novozym 435-Catalyzed Synthesis of UDCA-Monoglyceride
ena Tamburini
Bile acids (BAs) are a family of steroids synthesized from cholesterol in the liver. Among bile acids, ursodeoxycholic acid (UDCA) is the drug of choice for treating primary biliary cirrhosis and dissolving cholesterol gallstones. The clinical effectiveness of UDCA includes its choleretic activity, the capability to inhibit hydrophobic bile acid absorption by the intestine under cholestatic conditions, reducing cholangiocyte injury, stimulation of impaired biliary output, and inhibition of hepatocyte apoptosis. Despite its clinical effectiveness, UDCA is poorly soluble in the gastro-duodeno-jejunal conten...
Source: Molecules - October 1, 2021 Category: Chemistry Authors: Federico Zappaterra Stefania Costa Daniela Summa Bruno Semeraro Virginia Cristofori Claudio Trapella Elena Tamburini Tags: Article Source Type: research
Potential Therapeutic Effects of Ursodeoxycholic Acid in Comparison to Ramipril in a Rat model of Diabetic Nephropathy
ConclusionParticipation of ER stressmediated apoptosis in the pathophysiology of diabetic nephropathy make the UDCA a potential therapeutic option or add-on therapy due to its anti-apoptotic property apart from classic metabolic and hemodynamic aspects. (Source: QJM)
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research
Programmed Death-Ligand 1 (PD-L1) Gene Polymorphisms as Predictive Markers for Development of Hepatocellular Carcinoma in Chronic Hepatitis C Virus Patients
ConclusionThe present study demonstrated that the functional polymorphisms (rs4143815) (CG) of the PD-L1 gene were associated with HCC risk as it is expressed in (53.3%) of HCC, (25.6%) of cirrhosis and (23.1) % of control group. There is significant increase in rs4143815 (CG) with age as 95% of gene positive patients more than 50 years with no significance in gender smoking and DM. rs4143815 (CG) show significant increase in Child C patients as (75%) Child C vs. (10%) Child A and (45%) of patients was MELD/NA (20-29) vs. (10%)<9 and (70%) of patients were stage D in BCLC. (Source: QJM)
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research
Glycan biomarkers of autoimmunity and bile acid-associated alterations of the human glycome: Primary biliary cirrhosis and primary sclerosing cholangitis-specific glycans
Clin Immunol. 2021 Aug 14:108825. doi: 10.1016/j.clim.2021.108825. Online ahead of print.ABSTRACTWe have recently introduced multiple reaction monitoring (MRM) mass spectrometry as a novel tool for glycan biomarker research and discovery. Herein, we employ this technique to characterize the site-specific glycan alterations associated with primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). Glycopeptides associated with disease severity were also identified. Multinomial regression modelling was employed to construct and validate multi-analyte diagnostic models capable of accurately distinguishing PBC, ...
Source: Clinical Immunology - August 17, 2021 Category: Allergy & Immunology Authors: Emanual Maverakis Alexander A Merleev Dayoung Park Muchena J Kailemia Gege Xu L Renee Ruhaak Kyoungmi Kim Qiuting Hong Qiongyu Li Patrick Leung William Liakos Yu-Jui Yvonne Wan Christopher L Bowlus Alina I Marusina Nelvish N Lal Yixuan Xie Guillaume Luxar Source Type: research
Glycan biomarkers of autoimmunity and bile acid-associated alterations of the human glycome: Primary biliary cirrhosis and primary sclerosing cholangitis-specific glycans
Clin Immunol. 2021 Aug 14:108825. doi: 10.1016/j.clim.2021.108825. Online ahead of print.ABSTRACTWe have recently introduced multiple reaction monitoring (MRM) mass spectrometry as a novel tool for glycan biomarker research and discovery. Herein, we employ this technique to characterize the site-specific glycan alterations associated with primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). Glycopeptides associated with disease severity were also identified. Multinomial regression modelling was employed to construct and validate multi-analyte diagnostic models capable of accurately distinguishing PBC, ...
Source: Clinical Immunology - August 17, 2021 Category: Allergy & Immunology Authors: Emanual Maverakis Alexander A Merleev Dayoung Park Muchena J Kailemia Gege Xu L Renee Ruhaak Kyoungmi Kim Qiuting Hong Qiongyu Li Patrick Leung William Liakos Yu-Jui Yvonne Wan Christopher L Bowlus Alina I Marusina Nelvish N Lal Yixuan Xie Guillaume Luxar Source Type: research
Glycan biomarkers of autoimmunity and bile acid-associated alterations of the human glycome: Primary biliary cirrhosis and primary sclerosing cholangitis-specific glycans
Clin Immunol. 2021 Aug 14;230:108825. doi: 10.1016/j.clim.2021.108825. Online ahead of print.ABSTRACTWe have recently introduced multiple reaction monitoring (MRM) mass spectrometry as a novel tool for glycan biomarker research and discovery. Herein, we employ this technique to characterize the site-specific glycan alterations associated with primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). Glycopeptides associated with disease severity were also identified. Multinomial regression modelling was employed to construct and validate multi-analyte diagnostic models capable of accurately distinguishing P...
Source: Clinical Immunology - August 17, 2021 Category: Allergy & Immunology Authors: Emanual Maverakis Alexander A Merleev Dayoung Park Muchena J Kailemia Gege Xu L Renee Ruhaak Kyoungmi Kim Qiuting Hong Qiongyu Li Patrick Leung William Liakos Yu-Jui Yvonne Wan Christopher L Bowlus Alina I Marusina Nelvish N Lal Yixuan Xie Guillaume Luxar Source Type: research
Glycan biomarkers of autoimmunity and bile acid-associated alterations of the human glycome: Primary biliary cirrhosis and primary sclerosing cholangitis-specific glycans
Clin Immunol. 2021 Aug 14;230:108825. doi: 10.1016/j.clim.2021.108825. Online ahead of print.ABSTRACTWe have recently introduced multiple reaction monitoring (MRM) mass spectrometry as a novel tool for glycan biomarker research and discovery. Herein, we employ this technique to characterize the site-specific glycan alterations associated with primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). Glycopeptides associated with disease severity were also identified. Multinomial regression modelling was employed to construct and validate multi-analyte diagnostic models capable of accurately distinguishing P...
Source: Clinical Immunology - August 17, 2021 Category: Allergy & Immunology Authors: Emanual Maverakis Alexander A Merleev Dayoung Park Muchena J Kailemia Gege Xu L Renee Ruhaak Kyoungmi Kim Qiuting Hong Qiongyu Li Patrick Leung William Liakos Yu-Jui Yvonne Wan Christopher L Bowlus Alina I Marusina Nelvish N Lal Yixuan Xie Guillaume Luxar Source Type: research
Obeticholic acid ameliorates obesity and hepatic steatosis by activating brown fat
Exp Ther Med. 2021 Sep;22(3):991. doi: 10.3892/etm.2021.10423. Epub 2021 Jul 14.ABSTRACTObeticholic acid (OCA) is exemplified as a potent drug for treating primary biliary cirrhosis and nonalcoholic fatty liver disease by inhibiting bile acid synthesis. However, it remains unclear whether the effect of OCA is mediated by the function of brown adipose tissue (BAT). In the present study, brown adipogenesis differentiation in vitro and db/db mouse model treated with OCA were used to assess the anti-obesity function by body weight tracking, O2 consumption, food intake, physical activity, glucose tolerance tests. In addition, u...
Source: Experimental and Therapeutic Medicine - August 4, 2021 Category: General Medicine Authors: Hanlin Zhang Meng Dong Xiaomeng Liu Source Type: research
