Novel microbiota-related gene set enrichment analysis identified osteoporosis associated gut microbiota from autoimmune diseases
ConclusionOur study found that part of the gut microbiota could be novel regulators of BMDs and autoimmune diseases via the effects of its metabolites and may lead to a better understanding of the role played by gut microbiota in the communication of the microbiota-skeletal/immune-gut axis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 2, 2021 Category: Orthopaedics Source Type: research
Real Mentoring: Lessons from The Liver Queen
In 1970 I had the opportunity to spend time at the Royal Free Hospital in London. One of my professors at The University of Cincinnati College of Medicine, the late Leon Schiff, a renowned liver expert, arranged for me to work under Professor Sheila Sherlock. I was placed in a laboratory that was investigating the presumed immune basis of primary biliary cirrhosis. Roy Fox and Frank Dudley, the faculty in the lab, warmly welcomed me and taught me the basics of immunology research. My first scientific paper in Gut, was based on this work. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - August 2, 2021 Category: General Medicine Authors: Martin A. Samuels Tags: COMMENTARY Source Type: research
Real Mentoring: Lessons from ‘The Liver Queen’
In 1970, I had the opportunity to spend time at the Royal Free Hospital in London. One of my professors at the University of Cincinnati College of Medicine, the late Leon Schiff, a renowned liver expert, arranged for me to work under Professor Sheila Sherlock. I was placed in a laboratory that was investigating the presumed immune basis of primary biliary cirrhosis. Roy Fox and Frank Dudley, the faculty in the lab, warmly welcomed me and taught me the basics of immunology research. My first scientific paper in Gut, was based on this work. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - August 2, 2021 Category: General Medicine Authors: Martin A. Samuels Tags: COMMENTARY Source Type: research
Open-label, Multicenter Phase II Study of Combination Therapy of Imatinib Mesylate and Mycophenolate Mofetil in pediatric patients with Steroid-Refractory Sclerotic/fibrotic Type Chronic Graft-versus-host disease
Chronic graft-versus-host disease (cGVHD) is the most common late complication following allogeneic stem cell transplantation (SCT). This disease has variable features resembling autoimmune disorders such as scleroderma, primary biliary cirrhosis, bronchiolitis obliterans, and chronic immunodeficiency1. Thus, cGVHD can lead to debilitating complications such as joint contractures, blindness, and end-stage lung disease, which has a major impact on both survival and quality of life (QOL). (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - July 24, 2021 Category: Hematology Authors: Jung Yoon Choi, Hyery Kim, Hee Jo Baek, Hoon Kook, Jae Min Lee, Bo Kyung Kim, Hong Yul An, Kyung Taek Hong, Hee Young Shin, Hyoung Jin Kang Source Type: research
Myositis with Anti-mitochondrial Antibody Type 2 with Diplopia and Ptosis
Intern Med. 2021 May 7. doi: 10.2169/internalmedicine.7031-21. Online ahead of print.ABSTRACTAnti-mitochondrial antibody type 2 is a diagnostic marker of primary biliary cirrhosis and complicates myositis. Myositis with anti-mitochondrial antibody type 2 is clinically characterized by slowly progressive limb, cardiac, and respiratory muscle weakness as well as serum creatinine kinase elevations. However, there has been few cases with eye symptoms. We herein report a 59-year-old woman with anti-mitochondrial antibody type 2 who presented with diplopia and ptosis. Magnetic resonance imaging revealed bilateral ocular muscle e...
Source: Internal Medicine - May 10, 2021 Category: Internal Medicine Authors: Taichi Nomura Kosuke Iwami Azusa Nagai Kazufumi Tsuzaka Ichiro Yabe Source Type: research
Paricalcitol inhibits oxidative stress-induced cell senescence of the bile duct epithelium dependent on modulating Sirt1 pathway in cholestatic mice
CONCLUSION: Paricalcitol alleviated cholestatic liver injury through promoting the repair of damaged bile ducts and reducing oxidative stress-induced cell senescence of the bile duct via modulating Sirt1 pathway.PMID:33872698 | DOI:10.1016/j.freeradbiomed.2021.04.019 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 19, 2021 Category: Biology Authors: Rongjun Jia Fan Yang Pengfei Yan Liman Ma Longfei Yang Lihua Li Source Type: research
OptBand: optimization-based confidence bands for functions to characterize time-to-event distributions
AbstractClassical simultaneous confidence bands for survival functions (i.e., Hall –Wellner, equal precision, and empirical likelihood bands) are derived from transformations of the asymptotic Brownian nature of the Nelson–Aalen or Kaplan–Meier estimators. Due to the properties of Brownian motion, a theoretical derivation of the highest confidence density region cannot be ob tained in closed form. Instead, we provide confidence bands derived from a related optimization problem with local time processes. These bands can be applied to the one-sample problem regarding both cumulative hazard and survival functions. In ad...
Source: Lifetime Data Analysis - April 13, 2021 Category: Statistics Source Type: research
Human placenta mesenchymal stem cell-derived exosomes delay H2O2-induced aging in mouse cholangioids
Cholangiocyte senescence is an important pathological process in diseases such as primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). Stem cell/induced pluripotent stem cell-derived exoso... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 22, 2021 Category: Stem Cells Authors: Wenyi Chen, Jiaqi Zhu, Feiyan Lin, Yanping Xu, Bing Feng, Xudong Feng, Xinyu Sheng, Xiaowei Shi, Qiaoling Pan, Jinfeng Yang, Jiong Yu, Lanjuan Li and Hongcui Cao Tags: Research Source Type: research
Invited commentary on: Venous outflow reconstruction using polytetrafluoroethylene graft in right lobe living donor liver transplantation: A single center study
In July 1989, the first successful living donor liver transplant (LDLT) was performed by Strong et al and provided an alternative for pediatric patients with end stage liver disease awaiting deceased donor transplantation.1 Approximately 5 years later, at Shinshu University in Japan, the first adult LDLT was performed in a 53-year-old woman with primary biliary cirrhosis using a left lobe graft from the patient’s 25-year-old son.2 To address the issue of graft size, which limited use of the smaller left lobe graft in adults, the first right lobe adult LDLT, was subsequently performed by Lo et al in 1996 at the Univers...
Source: Surgery - March 3, 2021 Category: Surgery Authors: Madhukar S. Patel, Parsia A. Vagefi Source Type: research
