Novel microbiota-related gene set enrichment analysis identified osteoporosis associated gut microbiota from autoimmune diseases

AbstractIntroductionGut microbiota is now considered to be a hidden organ that interacts bidirectionally with cellular responses in numerous organs belonged to the immune, bone, and nervous systems. Here, we aimed to investigate the relationships between gut microbiota and complex diseases by utilizing multiple publicly available genome-wide association.Materials and methodsWe applied a novel microbiota-related gene set enrichment analysis approach to detect the associations between gut microbiota and complex diseases by processing genome-wide association studies (GWASs) data sets of six autoimmune diseases (including celiac disease (CeD), inflammatory bowel diseases (IBD), multiple sclerosis (MS), primary biliary cirrhosis (PBC), type 1 diabetes (T1D) and primary sclerosing cholangitis (PSC)) and osteoporosis (OP).ResultsThe familyOxalobacteraceae and genusCandidatus_Soleaferrea were found to be correlated with all of the six autoimmune diseases (FDR  adjusted P 
Source: Journal of Bone and Mineral Metabolism - Category: Orthopaedics Source Type: research

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Today's materials from the Intraclear Biologics team may be of interest to those following the development of senolytic therapies. Since the Mayo Clinic has yet to publish results from their clinical trials of fisetin as a senolytic therapy, and may not do so for a few years yet, it is good to see even preliminary data from other sources. Senolytic therapies selectively destroy senescent cells, though only one approach (the combination of dasatinib and quercetin) has been definitely shown to destroy significant numbers of senescent cells in humans. Data has yet to be published on whether fisetin performs as well in humans ...
Source: Fight Aging! - Category: Research Authors: Tags: Self-Experimentation Source Type: blogs
The antibiotic-free formulation shows potential as a targeted treatment for antimicrobial-resistant bacteria in chronic wounds such as diabetic foot ulcers, as well as a potential therapy for SARS-CoV-2.Medscape Medical News
Source: Medscape Dermatology Headlines - Category: Dermatology Tags: Infectious Diseases News Source Type: news
Parathyroidectomy is associated with a lower risk of fracture compared with nonsurgical management among older adults with primary hyperparathyroidism, a new study indicates.Reuters Health Information
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Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Consanguineous families have often played a role in the discovery of novel genes, especially in paediatric endocrinology. At this time, it has been estimated that over 8.5% of all children worldwide have consanguineous parents. Consanguinity is linked to demographic, cultural and religious practises and is more common in some areas around the world than others. In children with endocrine conditions from consanguineous families, there is a greater probability that a single gene condition with autosomal recessive inheritance is causative. From 1966 and the first description of Laron syndrome, through the discovery of the f...
Source: Hormone Research in Paediatrics - Category: Endocrinology Source Type: research
SAN DIEGO, Nov. 30, 2021 -- (Healthcare Sales &Marketing Network) -- ViaCyte, Inc., a clinical-stage regenerative medicine company developing novel cell replacement therapies to address diseases with significant unmet needs, today announced the appointme... Regenerative Medicine, Personnel ViaCyte, cell therapy, diabetes
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We present the case of a 76-year-old woman who had a recurrence of pemphigus vulgaris limited to the irradiation field after exposure to an adjuvant radiotherapy treatment for a bilateral triple-negative breast cancer. The onset was bilateral limited to the irradiation area and was treated effectively with local and systemic corticosteroids. After a rigorous review of the literature, only 16 cases of breast cancer radiation-induced pemphigus appeared. In contrast to several cases, the rash was limited to the irradiated area and improved with systemic corticosteroids. For more than three-quarters of the described cases in t...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
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OBJECTIVE: To explore the association between frailty and history of falls in people living with multiple sclerosis (MS). DESIGN: Secondary analysis. SETTING: University research laboratories in the United States and Israel. PARTICIPANTS: 118 peopl...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
AbstractDiabetic kidney disease (DKD) is a highly prevalent complication of Diabetes Mellitus (DM) and the leading cause of end-stage kidney disease (ESKD). Inflammation is recognized as an important driver of progression of DKD. Activation of the immune response promotes a pro-inflammatory milieu and subsequently renal fibrosis and a progressive loss of renal function. While the role of the innate immune system in diabetic renal disease has been well characterised, the potential contribution of the adaptive immune system remains poorly defined. Emerging evidence in experimental models of DKD indicates an increase in the n...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: REVIEW ARTICLE Source Type: research
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