The proportion of CD161 on CD56+ NK cells in peripheral circulation associates with clinical features and disease activity of primary Sj ögren's syndrome
ConclusionThis study suggested that the proportion of CD56+ NK cells and CD161+CD56+ NK cells decreased significantly in pSS patients, and the proportion of CD161+CD56+ NK cells negatively associated with the clinical features and disease activity of pSS patients. CD161 expression inhibited the function of CD56+ NK cells in peripheral blood of pSS patients. The CD161+CD56+ NK cells may present as a potential target for therapy and a biomarker of disease activity in pSS. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 5, 2024 Category: Allergy & Immunology Authors: Ping Zhao,
Yanhong Yang,
Saizhe Song,
Wei Cheng,
Cheng Peng,
Xin Chang,
Jian Wu,
Cuiping Liu Tags: ORIGINAL ARTICLE Source Type: research
The casual relationship between autoimmune diseases and multiple myeloma: a Mendelian randomization study
AbstractObservational studies showed possible associations between systemic lupus erythematosus and multiple myeloma. However, whether there is a casual relationship between different types of autoimmune diseases (type 1 diabetes mellitus, rheumatoid arthritis, systemic lupus erythematosus, psoriasis, multiple sclerosis, primary sclerosing cholangitis, primary biliary cirrhosis, and juvenile idiopathic arthritis) and multiple myeloma (MM) is not well known. We performed a two-sample Mendelian randomization (MR) study to estimate the casual relationship. Summary-level data of autoimmune diseases were gained from published g...
Source: Clinical and Experimental Medicine - April 2, 2024 Category: Research Source Type: research
Impact of liver diseases and pharmacological interactions on the transportome involved in hepatic drug disposition
Biochem Pharmacol. 2024 Mar 23:116166. doi: 10.1016/j.bcp.2024.116166. Online ahead of print.ABSTRACTThe liver plays a pivotal role in drug disposition owing to the expression of transporters accounting for the uptake at the sinusoidal membrane and the efflux across the basolateral and canalicular membranes of hepatocytes of many different compounds. Moreover, intracellular mechanisms of phases I and II biotransformation generate, in general, inactive compounds that are more polar and easier to eliminate into bile or refluxed back toward the blood for their elimination by the kidneys, which becomes crucial when the biliary...
Source: Biochemical Pharmacology - March 25, 2024 Category: Drugs & Pharmacology Authors: Jose J G Marin Candela Cives-Losada Rocio I R Macias Marta R Romero Rebeca P Marijuan Nazaret Hortelano-Hernandez Kevin Delgado-Calvo Carmen Villar Jesus M Gonzalez-Santiago Maria J Monte Maitane Asensio Source Type: research
Impact of liver diseases and pharmacological interactions on the transportome involved in hepatic drug disposition
Biochem Pharmacol. 2024 Mar 23:116166. doi: 10.1016/j.bcp.2024.116166. Online ahead of print.ABSTRACTThe liver plays a pivotal role in drug disposition owing to the expression of transporters accounting for the uptake at the sinusoidal membrane and the efflux across the basolateral and canalicular membranes of hepatocytes of many different compounds. Moreover, intracellular mechanisms of phases I and II biotransformation generate, in general, inactive compounds that are more polar and easier to eliminate into bile or refluxed back toward the blood for their elimination by the kidneys, which becomes crucial when the biliary...
Source: Biochemical Pharmacology - March 25, 2024 Category: Drugs & Pharmacology Authors: Jose J G Marin Candela Cives-Losada Rocio I R Macias Marta R Romero Rebeca P Marijuan Nazaret Hortelano-Hernandez Kevin Delgado-Calvo Carmen Villar Jesus M Gonzalez-Santiago Maria J Monte Maitane Asensio Source Type: research
Primary biliary cholangitis presenting with granulomatous lung disease misdiagnosed as lung cancer: A case report
CONCLUSION: Diagnosis of pulmonary nodules requires integrating various clinical data to avoid unnecessary pulmonary lobectomy.PMID:38313637 | PMC:PMC10835678 | DOI:10.12998/wjcc.v12.i2.354 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - February 5, 2024 Category: Cancer & Oncology Authors: Shan-Li Feng Jun-Yao Li Chun-Ling Dong Source Type: research
Potential clinical implications of molecular mimicry ‐induced autoimmunity
ConclusionsMolecular mimicry plausibly explains initial stages of autoimmune pathogenesis induced by infection or microbiota disturbances. Understanding mimicry antigens and pathways could enable improved prediction, monitoring, and antigen-specific immunotherapy for autoimmune disorders. However, definitive proof of causation in humans remains limited. Further research should focus on establishing clinical evidence and utility. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 1, 2024 Category: Allergy & Immunology Authors: Bandar A Suliman Tags: REVIEW ARTICLE Source Type: research
Mitigation of intrahepatic cholestasis induced by 17 α-ethinylestradiol via nanoformulation of Silybum marianum L.
Cholestasis is an important predisposing factor for hepatocyte damage, liver fibrosis, primary biliary cirrhosis, and even liver failure. Silybum marianum L. (SM) plant is used in teas or eaten in some countries ... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - January 23, 2024 Category: Complementary Medicine Authors: Maha B. Salem, Dina Mostafa Mohammed, Olfat A. Hammam and Mohamed Elzallat Tags: Research Source Type: research
Primary biliary cirrhosis and osteoporosis: a bidirectional two-sample Mendelian randomization study
ConclusionThis study establishes a positive causal relationship between PBC and the risk of osteoporosis, while no definitive causal link was found from osteoporosis to PBC. These findings offer new insights and guidance for managing bone health in PBC patients. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - December 14, 2023 Category: Allergy & Immunology Source Type: research
Human Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASC42, a Novel Farnesoid X Receptor Agonist
ConclusionASC42 was well tolerated with a pharmacokinetic profile suitable for QD dosing, and demonstrated dose-dependent targets engagement without altering plasma cholesterol in healthy subjects.Trial registration numberNCT04679129. (Source: Drugs in R&D)
Source: Drugs in R&D - November 2, 2023 Category: Drugs & Pharmacology Source Type: research
P333 Clinical, pathological heterogeneity and mitochondrial dysfunction in patients with anti-mitochondrial antibodies related myositis
Inflammatory myopathies are a heterogeneous group of rare, acquired autoimmune diseases involving skeletal muscle and other organs and/or tissue. Myositis specific or associated antibodies are commonly correlated with distinct clinical phenotypes of inflammatory myopathies and have helped to refine the classification. Anti-mitochondrial antibodies (AMAs), the hallmark of primary biliary cirrhosis, have been reported in patients with inflammatory myopathies. We aimed to reveal the clinical and histopathological characteristics and explore the mitochondrial dysfunction in patients with AMAs related myopathies. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - October 1, 2023 Category: Neurology Authors: W. Zhang, Y. Wang, Y. Zhao, Y. Yuan Source Type: research
Genes, Vol. 14, Pages 1844: Association between Gastric Cancer and 12 Autoimmune Diseases: A Mendelian Randomization Study
Conclusion: Our study did not find a genetic causal relationship between susceptibility to these autoimmune diseases and GC, which suggests that unmeasured confounders (e.g., inflammatory processes) or shared genetic architecture may be responsible for the reported epidemiologic associations. Further studies of ancestral diversity are warranted to validate such causal associations. (Source: Genes)
Source: Genes - September 23, 2023 Category: Genetics & Stem Cells Authors: Qi Wei Ziyu Wang Xuanyu Liu Haibin Liang Lei Chen Tags: Article Source Type: research
Bile acids as signaling molecules: Role of ursodeoxycholic acid in cholestatic liver disease
The objective of this work seeks to describe the main molecular mechanisms by which UDCA acts in the human body, emphasizing the interaction in other tissues than the liver.PMID:37594109 | DOI:10.2174/1389203724666230818092800 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - August 18, 2023 Category: Biochemistry Authors: Eduardo Cifuentes-Silva Claudio Cabello-Verrugio Source Type: research
Bile acids as signaling molecules: Role of ursodeoxycholic acid in cholestatic liver disease
The objective of this work seeks to describe the main molecular mechanisms by which UDCA acts in the human body, emphasizing the interaction in other tissues than the liver.PMID:37594109 | DOI:10.2174/1389203724666230818092800 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - August 18, 2023 Category: Biochemistry Authors: Eduardo Cifuentes-Silva Claudio Cabello-Verrugio Source Type: research
Bile acids as signaling molecules: Role of ursodeoxycholic acid in cholestatic liver disease
The objective of this work seeks to describe the main molecular mechanisms by which UDCA acts in the human body, emphasizing the interaction in other tissues than the liver.PMID:37594109 | DOI:10.2174/1389203724666230818092800 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - August 18, 2023 Category: Biochemistry Authors: Eduardo Cifuentes-Silva Claudio Cabello-Verrugio Source Type: research
Bile acids as signaling molecules: Role of ursodeoxycholic acid in cholestatic liver disease
The objective of this work seeks to describe the main molecular mechanisms by which UDCA acts in the human body, emphasizing the interaction in other tissues than the liver.PMID:37594109 | DOI:10.2174/1389203724666230818092800 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - August 18, 2023 Category: Biochemistry Authors: Eduardo Cifuentes-Silva Claudio Cabello-Verrugio Source Type: research
