Prevalence and clinical characteristics of autoimmune liver disease in hospitalized patients with cirrhosis and acute decompensation in China
CONCLUSION: AILD was not rare in hospitalized patients with cirrhosis and AD in China, among which PBC was the most common etiology. 90-d LT-free mortality were independently associated with TB, HE and BUN.PMID:36159019 | PMC:PMC9453760 | DOI:10.3748/wjg.v28.i31.4417 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - September 26, 2022 Category: Gastroenterology Authors: Zi-Xuan Shen Dan-Dan Wu Jie Xia Xian-Bo Wang Xin Zheng Yan Huang Bei-Ling Li Zhong-Ji Meng Yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Jia Shang Hua-Dong Yan Yu-Bao Zheng Wen-Yi Gu Yan Zhang Jian-Yi Wei Wen-Ting Tan Yi-Xin Hou Qun Zhang Yan Xiong Cong- Source Type: research
Prevalence and clinical characteristics of autoimmune liver disease in hospitalized patients with cirrhosis and acute decompensation in China
CONCLUSION: AILD was not rare in hospitalized patients with cirrhosis and AD in China, among which PBC was the most common etiology. 90-d LT-free mortality were independently associated with TB, HE and BUN.PMID:36159019 | PMC:PMC9453760 | DOI:10.3748/wjg.v28.i31.4417 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 26, 2022 Category: Gastroenterology Authors: Zi-Xuan Shen Dan-Dan Wu Jie Xia Xian-Bo Wang Xin Zheng Yan Huang Bei-Ling Li Zhong-Ji Meng Yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Jia Shang Hua-Dong Yan Yu-Bao Zheng Wen-Yi Gu Yan Zhang Jian-Yi Wei Wen-Ting Tan Yi-Xin Hou Qun Zhang Yan Xiong Cong- Source Type: research
Prevalence and clinical characteristics of autoimmune liver disease in hospitalized patients with cirrhosis and acute decompensation in China
CONCLUSION: AILD was not rare in hospitalized patients with cirrhosis and AD in China, among which PBC was the most common etiology. 90-d LT-free mortality were independently associated with TB, HE and BUN.PMID:36159019 | PMC:PMC9453760 | DOI:10.3748/wjg.v28.i31.4417 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - September 26, 2022 Category: Gastroenterology Authors: Zi-Xuan Shen Dan-Dan Wu Jie Xia Xian-Bo Wang Xin Zheng Yan Huang Bei-Ling Li Zhong-Ji Meng Yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Jia Shang Hua-Dong Yan Yu-Bao Zheng Wen-Yi Gu Yan Zhang Jian-Yi Wei Wen-Ting Tan Yi-Xin Hou Qun Zhang Yan Xiong Cong- Source Type: research
Long-Term Outcome of a Series of Patients With Narcolepsy Type 1 and Comorbidity With Immunopathological and Autoimmune Diseases
CONCLUSIONS: The prevalence of AD/ID is high in our series, suggesting that NT1 might arise on a background of generalized susceptibility to immune-mediated processes. The occurrence of an ID can in turn influence the development of others in genetically predisposed individuals, which explains the increased associations observed in this long-term study.PMID:36128006 | PMC:PMC9451554 | DOI:10.14740/jocmr4758 (Source: Clin Med Res)
Source: Clin Med Res - September 21, 2022 Category: Research Authors: Francisco J Martinez-Orozco Miguel Fernandez-Arquero Jose L Vicario Laura Lillo-Triguero Elena Ameyugo Rosa Peraita-Adrados Source Type: research
Long-Term Outcome of a Series of Patients With Narcolepsy Type 1 and Comorbidity With Immunopathological and Autoimmune Diseases
CONCLUSIONS: The prevalence of AD/ID is high in our series, suggesting that NT1 might arise on a background of generalized susceptibility to immune-mediated processes. The occurrence of an ID can in turn influence the development of others in genetically predisposed individuals, which explains the increased associations observed in this long-term study.PMID:36128006 | PMC:PMC9451554 | DOI:10.14740/jocmr4758 (Source: Clin Med Res)
Source: Clin Med Res - September 21, 2022 Category: Research Authors: Francisco J Martinez-Orozco Miguel Fernandez-Arquero Jose L Vicario Laura Lillo-Triguero Elena Ameyugo Rosa Peraita-Adrados Source Type: research
Long-Term Outcome of a Series of Patients With Narcolepsy Type 1 and Comorbidity With Immunopathological and Autoimmune Diseases
CONCLUSIONS: The prevalence of AD/ID is high in our series, suggesting that NT1 might arise on a background of generalized susceptibility to immune-mediated processes. The occurrence of an ID can in turn influence the development of others in genetically predisposed individuals, which explains the increased associations observed in this long-term study.PMID:36128006 | PMC:PMC9451554 | DOI:10.14740/jocmr4758 (Source: Clin Med Res)
Source: Clin Med Res - September 21, 2022 Category: Research Authors: Francisco J Martinez-Orozco Miguel Fernandez-Arquero Jose L Vicario Laura Lillo-Triguero Elena Ameyugo Rosa Peraita-Adrados Source Type: research
Long-Term Outcome of a Series of Patients With Narcolepsy Type 1 and Comorbidity With Immunopathological and Autoimmune Diseases
CONCLUSIONS: The prevalence of AD/ID is high in our series, suggesting that NT1 might arise on a background of generalized susceptibility to immune-mediated processes. The occurrence of an ID can in turn influence the development of others in genetically predisposed individuals, which explains the increased associations observed in this long-term study.PMID:36128006 | PMC:PMC9451554 | DOI:10.14740/jocmr4758 (Source: Clin Med Res)
Source: Clin Med Res - September 21, 2022 Category: Research Authors: Francisco J Martinez-Orozco Miguel Fernandez-Arquero Jose L Vicario Laura Lillo-Triguero Elena Ameyugo Rosa Peraita-Adrados Source Type: research
Long-Term Outcome of a Series of Patients With Narcolepsy Type 1 and Comorbidity With Immunopathological and Autoimmune Diseases
CONCLUSIONS: The prevalence of AD/ID is high in our series, suggesting that NT1 might arise on a background of generalized susceptibility to immune-mediated processes. The occurrence of an ID can in turn influence the development of others in genetically predisposed individuals, which explains the increased associations observed in this long-term study.PMID:36128006 | PMC:PMC9451554 | DOI:10.14740/jocmr4758 (Source: Clin Med Res)
Source: Clin Med Res - September 21, 2022 Category: Research Authors: Francisco J Martinez-Orozco Miguel Fernandez-Arquero Jose L Vicario Laura Lillo-Triguero Elena Ameyugo Rosa Peraita-Adrados Source Type: research
Role of TL1A in Inflammatory Autoimmune Diseases: A Comprehensive Review
In this study, we comprehensively discussed the complex immunological function of TL1A and focused on recent findings of the pleiotropic activity conducted by TL1A in inflammatory autoimmune disease. Finish of the study will provide new ideas for developing therapeutic strategies for these diseases by targeting TL1A. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - July 14, 2022 Category: Allergy & Immunology Source Type: research
The Role of Gut Microbiota in Some Liver Diseases: From an Immunological Perspective
Gut microbiota is a microecosystem composed of various microorganisms. It plays an important role in human metabolism, and its metabolites affect different tissues and organs. Intestinal flora maintains the intestinal mucosal barrier and interacts with the immune system. The liver is closely linked to the intestine by the gut-liver axis. As the first organ that comes into contact with blood from the intestine, the liver will be deeply influenced by the gut microbiota and its metabolites, and the intestinal leakage and the imbalance of the flora are the trigger of the pathological reaction of the liver. In this paper, we di...
Source: Frontiers in Immunology - July 13, 2022 Category: Allergy & Immunology Source Type: research
Reactive lymphoid hyperplasia (RLH) of the liver: An illustrative case
Reactive lymphoid hyperplasia (RLH) of the liver, also known as pseudolymphoma, is a rare benign entity usually discovered in radiological work-up resembling a malignant neoplasia. RLH has been associated with autoimmune diseases, chronic liver disease, and primary biliary cirrhosis. At microscopy, RLH is characterized by a nodular proliferation of mature-appearing lymphocytes without atypias and lymphoid follicles. Surgical excision is suggested both for diagnosis and treatment of liver RLH, since it is difficult to diagnose low grade lymphomas in liver biopsy [1]. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 22, 2022 Category: Gastroenterology Authors: Eduardo Cambruzzi, Jo ão Pedro Pattussi Bertinatti Tags: Image of the Month Source Type: research
GSE186399 Transcriptome sequencing of CD8 αα T cells and CD8αβ T cells in liver of dnTGFβRII mice.
Contributors : Zhen-Hua Bian ; Yi-Chen HanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe characterized the tcr repertoire diversity of CD8 αα T cells and CD8αβ T cells in liver microenvironment of in dnTGFβRII mice, a classical Primary Biliary Cirrhosis mouse model . (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 22, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Liquid chromatography coupled to tandem mass spectrometry methods for the selective and sensitive determination of 24S ‐hydroxycholesterol, its sulphate and/or glucuronide conjugates in plasma
Abstract24S-hydroxycholesterol (i.e cerebrosterol, 24S-OH-Chol) is the main form of cholesterol elimination from the brain. Liquid chromatography-tandem mass spectrometry methods were developed for the quantification of the total and unesterified/unbound fractions of 24S-OH-Chol, its monosulfate, monoglucuronide and diconjugate derivatives (24S-OH-Chol-3sulfate [3S], 24S-OH-Chol-24glucuronide [24G] and 24S-OH-Chol-3S, 24G, respectively) in human plasma. Linearity, precision, accuracy and extraction recovery were validated within the typical physiological and pathological ranges of concentrations for each compound. The lowe...
Source: Journal of Mass Spectrometry - April 7, 2022 Category: Chemistry Authors: Val érie Brousseau,
Patrick Caron,
Jocelyn Trottier,
Thérèse Di Paolo,
Piotr Milkiewicz,
Olivier Barbier Tags: RESEARCH ARTICLE Source Type: research
A molecular mechanism of UDCA engagement with GPBAR and subsequent G protein interaction revealed by scattered alanine scanning
In this study, we delineated the interaction of UDCA with GPBAR and activation mechanism of GPBAR by scattered alanine scanning and molecular docking. Our results indicated that transmembrane helix 2 (TM2), TM3, TM5 and TM6 of GPBAR contribute to the interaction of UDCA in GPBAR binding pocket. Moreover, we predicted that the engagement of the 3-OH of UDCA with phenolic oxygen of Y2406.51 in GPBAR plays a key role in GPBAR activation. Unexpectedly, in addition to the well-known roles of intracellular loop2 (ICL2) residues, we identified that ICL3 residues play an important role in G protein coupling to GPBAR in response to...
Source: Biochemical and Biophysical Research communications - February 19, 2022 Category: Biochemistry Authors: Ruirui Lu Xu Yan Guoxing Fang Yuming Zhuang Lulu Guo Chao Zhang Xiang Wu Peng Xiao Yiwen Cao Fan Yang Xiao Yu Jin-Peng Sun Jiu-Yao Zhou Source Type: research
The gut-liver axis in cholangiopathies: focus on bile acid based pharmacological treatment
Purpose of review
This review analyses the main features of primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) and provides an overview of the currently available (bile acid) bile acid related treatments.
Recent findings
In PBC, biliary injury is the consequence of a dysregulated intrahepatic and systemic immune response. Given the close association between PSC and inflammatory bowel disease (IBD), the microbiota represents an important factor in the development of PSC. Bile acid based pharmacological treatments could represent promising therapeutic strategies in the management of cholangio...
Source: Current Opinion in Gastroenterology - February 3, 2022 Category: Gastroenterology Tags: BILIARY TRACT: Edited by Chantal Housset Source Type: research
