[ASAP] Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine < italic toggle="yes" > O < /italic > -Acetyltransferase Inhibitor
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00627 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 20, 2020 Category: Chemistry Authors: Joana Magalha~es †, Nina Franko‡, Samanta Raboni‡#, Giannamaria Annunziato†, Pa¨ivi Tammela§, Agostino Bruno†?, Stefano Bettati??#, Andrea Mozzarelli‡?#, Marco Pieroni*†?, Barbara Campanini‡, and Gabriele Costantino†?? Source Type: research

[ASAP] Predictive Gene Signature for Pyrazolopyrimidine Derivative c-Src Inhibitor 10a Sensitivity in Melanoma Cells
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00679 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 20, 2020 Category: Chemistry Authors: Baris Kucukkaraduman †, Can Turk‡, Anna L. Fallacara?, Murat Isbilen§, Kerem M. Senses?, Zeynep O. Ayyildiz?, Muhammad W. Akbar†, Michal Lotem#, Maurizio Botta??, and Ali O. Gure*† Source Type: research

[ASAP] Pharmacophore-Based Design of New Chemical Scaffolds as Translational Readthrough-Inducing Drugs (TRIDs)
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00609 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 20, 2020 Category: Chemistry Authors: Marco Tutone* †, Ivana Pibiri*†, Riccardo Perriera†, Ambra Campofelice†, Giulia Culletta†‡, Raffaella Melfi†, Andrea Pace†, Anna Maria Almerico†, and Laura Lentini† Source Type: research

[ASAP] Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00604 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 20, 2020 Category: Chemistry Authors: Alessia Romussi* †#?, Anna Cappa†#?, Paola Vianello†?, Silvia Brambillasca†#, Maria Rosaria Cera†#, Roberto Dal Zuffo†#, Giovanni Faga`†#, Raimondo Fattori†#, Loris Moretti†?, Paolo Trifiro`†#, Manuela Villa†#, Stefania Vultaggio†# Source Type: research

[ASAP] Efficacy and Tolerability of Pyrazolo[1,5- < italic toggle="yes" > a < /italic > ]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00015 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 19, 2020 Category: Chemistry Authors: Casey J. N. Mathison* †, Donatella Chianelli†, Paul V. Rucker†, John Nelson†, Jason Roland†, Zhihong Huang†, Yang Yang†, Jiqing Jiang†, Yun Feng Xie†, Robert Epple†, Badry Bursulaya†, Christian Lee†, Mu-Yun Gao†, Jennifer Shaffer Source Type: research

[ASAP] Development of Pyrazolo[3,4- < italic toggle="yes" > d < /italic > ]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00530 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 19, 2020 Category: Chemistry Authors: Chiara Greco †#, Vincenzo Taresco‡#, Amanda K. Pearce§, Catherine E. Vasey?, Stuart Smith?, Ruman Rahman?, Cameron Alexander?, Robert J. Cavanagh*?, Francesca Musumeci*†, and Silvia Schenone† Source Type: research

[ASAP] Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00611 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 18, 2020 Category: Chemistry Authors: Zhili Xin †, Martin K. Himmelbauer†, J. Howard Jones†, Istvan Enyedy†, Rab Gilfillan†, Thomas Hesson‡, Kristopher King§, Douglas J. Marcotte?, Paramasivam Murugan‡, Joseph C. Santoro‡, and Felix Gonzalez-Lopez de Turiso*† Source Type: research

[ASAP] Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00672 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 18, 2020 Category: Chemistry Authors: Sida Shen †, Peter F. Doubleday‡, Pathum M. Weerawarna†, Wei Zhu†, Neil L. Kelleher†‡, and Richard B. Silverman*†‡§ Source Type: research

[ASAP] Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00553 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 18, 2020 Category: Chemistry Authors: Sylvestre P. J. T. Bachollet †§, Vito Vece†§, Alison N. McCracken‡§, Brendan T. Finicle‡, Elizabeth Selwan‡, Nadine Ben Romdhane‡, Amogha Dahal‡, Cuauhtemoc Ramirez‡, Aimee L. Edinger*‡, and Stephen Hanessian*† Source Type: research

[ASAP] New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00644 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 18, 2020 Category: Chemistry Authors: Rita Meleddu †, Simona Distinto*†, Filippo Cottiglia†, Rossella Angius‡, Pierluigi Caboni†, Andrea Angeli§, Claudia Melis†, Serenella Deplano†, Stefano Alcaro?, Francesco Ortuso?, Claudiu T. Supuran*§, and Elias Maccioni† Source Type: research

[ASAP] Discovery of Membrane-Bound Pyrophosphatase Inhibitors Derived from an Isoxazole Fragment
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00537 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 17, 2020 Category: Chemistry Authors: Niklas G. Johansson †#, Ainoleena Turku†#, Keni Vidilaseris‡#, Loi¨c Dreano†, Ayman Khattab§, Daniel Ayuso Pe´rez†, Aaron Wilkinson?, Yuezhou Zhang†?, Matti Tamminen†, Evgeni Grazhdankin†, Alexandros Kiriazis†, Colin W. G. Fishwick?, Source Type: research

[ASAP] Evaluation of Pan-SSTRs Targeted Radioligand [ < sup > 64 < /sup > Cu]NOTA-PA1 Using Micro-PET Imaging in Xenografted Mice
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00544 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 14, 2020 Category: Chemistry Authors: Fei Liu †‡, Xiaoyi Guo‡, Teli Liu‡, Xiaoxia Xu‡, Nan Li‡, Chiyi Xiong§, Chun Li§, Hua Zhu*‡, and Zhi Yang*‡ Source Type: research

[ASAP] Synthesis and Structure –Activity Relationship of Pyxinol Derivatives as Novel Anti-Inflammatory Agents
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00562 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 14, 2020 Category: Chemistry Authors: Yixiao Sun †§, Xiaojuan Fang†§, Meng Gao†, Conghui Wang†, Hongyan Gao†, Wenjing Bi†, Hanhan Tang†, Yetong Cui†, Leiming Zhang†, Huaying Fan†, Hui Yu*‡, and Gangqiang Yang*† Source Type: research

[ASAP] Direct Comparison of (N)-Methanocarba and Ribose-Containing 2-Arylalkynyladenosine Derivatives as A < sub > 3 < /sub > Receptor Agonists
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00637 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 14, 2020 Category: Chemistry Authors: Dilip K. Tosh †, Veronica Salmaso†, Harsha Rao†, Ryan Campbell†, Amelia Bitant?, Zhan-Guo Gao†, John A. Auchampach?, and Kenneth A. Jacobson*† Source Type: research

[ASAP] Synthesis and Antiproliferative Activity of Nitric Oxide-Donor Largazole Prodrugs
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00643 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 14, 2020 Category: Chemistry Authors: Matteo Borgini †, Claudio Zamperini†‡, Federica Poggialini†, Luca Ferrante?, Vincenzo Summa??, Maurizio Botta?†‡§#, and Romano Di Fabio*??? Source Type: research

[ASAP] Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00621 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 13, 2020 Category: Chemistry Authors: Peter Blomgren †, Jayaraman Chandrasekhar†, Julie A. Di Paolo‡, Wanchi Fung‡, Guoju Geng‡, Carmen Ip‡, Randall Jones†, Jeffrey E. Kropf†, Eric B. Lansdon‡, Seung Lee†, Jennifer R. Lo†, Scott A. Mitchell†, Bernard Murray‡, Chris P Source Type: research

[ASAP] Dethioacylation by Sirtuins 1 –3: Considerations for Drug Design Using Mechanism-Based Sirtuin Inhibition
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00580 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 12, 2020 Category: Chemistry Authors: Nima Rajabi, Alexander L. Nielsen, and Christian A. Olsen* Source Type: research

[ASAP] Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00656 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 12, 2020 Category: Chemistry Authors: Marco Catto* †, Leonardo Pisani†, Eugenio de la Mora‡, Benny Danilo Belviso§, Giuseppe Felice Mangiatordi§, Andrea Pinto?, Annalisa De Palma?, Nunzio Denora†, Rocco Caliandro§, Jacques-Philippe Colletier‡, Israel Silman#, Orazio Nicolotti†, Source Type: research

[ASAP] Pyridine Derivative of the Natural Alkaloid Berberine as Human Telomeric G < sub > 4 < /sub > -DNA Binder: A Solution and Solid-State Study
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00516 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 12, 2020 Category: Chemistry Authors: Francesco Papi †, Carla Bazzicalupi*†, Marta Ferraroni†, Giulia Ciolli†, Paolo Lombardi‡, Asma Yasmeen Khan§?, Gopinatha Suresh Kumar§, and Paola Gratteri*? Source Type: research

[ASAP] From PARP1 to TNKS2 Inhibition: A Structure-Based Approach
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00654 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 11, 2020 Category: Chemistry Authors: Stefano Tomassi ¥, Julian Pfahler?, Nicola Mautone§, Annarita Rovere§, Chiara Esposito?, Daniela Passeri+, Roberto Pellicciari+, Ettore Novellino¥, Martin Pannek?, Clemens Steegborn*?, Alessandro Paiardini*?, Antonello Mai*§, and Dante Rotili*§ Source Type: research

[ASAP] Structure-Guided Identification of DNMT3B Inhibitors
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00011 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 11, 2020 Category: Chemistry Authors: Ana S. Newton †, John C. Faver†, Goran Micevic§, Viswanathan Muthusamy?, Shalley N. Kudalkar‡, Nicole Bertoletti‡, Karen S. Anderson‡, Marcus W. Bosenberg§??, and William L. Jorgensen*† Source Type: research

[ASAP] New 8-Nitroquinolinone Derivative Displaying Submicromolar < italic toggle="yes" > in Vitro < /italic > Activities against Both < italic toggle="yes" > Trypanosoma brucei < /italic > and < italic toggle="yes" > cruzi < /italic >
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00566 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 11, 2020 Category: Chemistry Authors: Julien Pedron †+, Clotilde Boudot‡+, Jean-Yves Brossas§, Emilie Pinault?, Sandra Bourgeade-Delmas?, Alix Sournia-Saquet†, Elisa Boutet-Robinet#, Alexandre Destere?, Antoine Tronnet†, Justine Berge´†, Colin Bonduelle†, Ce´line Deraeve†, Ge Source Type: research

[ASAP] Azole Based Acetohydrazide Derivatives of Cinnamaldehyde Target and Kill < italic toggle="yes" > Candida albicans < /italic > by Causing Cellular Apoptosis
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00030 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 10, 2020 Category: Chemistry Authors: Mohmmad Younus Wani* †, Aijaz Ahmad#§, Faisal Mohammed Aqlan†, and Abdullah Saad Al-Bogami† Source Type: research

[ASAP] Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00658 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 7, 2020 Category: Chemistry Authors: Jiaqian Xu †‡, Zhang Zhang†, Ligen Lin§, Hongyan Sun‡, Lorenzo V. White†, Ke Ding*†, and Zhengqiu Li*† Source Type: research

[ASAP] Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00509 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 6, 2020 Category: Chemistry Authors: Zenon Konteatis †, Erin Artin†‡, Brandon Nicolay†, Kimberly Straley†§, Anil K. Padyana†, Lei Jin†, Yue Chen†, Rohini Narayaraswamy†, Shuilong Tong?, Feng Wang?, Ding Zhou?=, Dawei Cui??, Zhenwei Cai?, Zhiyong Luo8, Cheng Fang8, Huachun Source Type: research

[ASAP] BOPC1 Enantiomers Preparation and HuR Interaction Study. From Molecular Modeling to a Curious DEEP-STD NMR Application
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00659 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 4, 2020 Category: Chemistry Authors: Serena Della Volpe †¶, Roberta Listro†, Michela Parafioriti†, Marcello Di Giacomo†, Daniela Rossi†, Francesca Alessandra Ambrosio?, Giosue` Costa*?#, Stefano Alcaro?#, Francesco Ortuso?#, Anna K. H. Hirsch§?, Francesca Vasile*¶, and Simona Co Source Type: research

[ASAP] Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGF ßR1 Inhibitor as an Immuno-oncology Agent
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00552 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 4, 2020 Category: Chemistry Authors: Upender Velaparthi* †, Chetan Padmakar Darne†, Jayakumar Warrier‡, Peiying Liu†, Hasibur Rahaman‡, Karen Augustine-Rauch†, Karen Parrish†, Zheng Yang†, Jesse Swanson†, Jennifer Brown†, Gopal Dhar‡, Aravind Anandam‡, Vinay K. Holena Source Type: research

[ASAP] Utility of Physicochemical Properties for the Prediction of Toxicological Outcomes: Takeda Perspective
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00536 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 3, 2020 Category: Chemistry Authors: Tomoya Yukawa* and Russell Naven Source Type: research

[ASAP] Synthesis and SAR Studies of 1 < italic toggle="yes" > H < /italic > -Pyrrolo[2,3- < italic toggle="yes" > b < /italic > ]pyridine-2-carboxamides as Phosphodiesterase 4B (PDE4B) Inhibitors
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00369 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - February 3, 2020 Category: Chemistry Authors: Anish K. Vadukoot †, Swagat Sharma†, Christopher D. Aretz†, Sushil Kumar†, Nagsen Gautam†, Yazen Alnouti†, Amy L. Aldrich‡, Cortney E. Heim‡, Tammy Kielian‡, and Corey R. Hopkins*† Source Type: research

[ASAP] Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00578 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 31, 2020 Category: Chemistry Authors: Toshio Kawanami ‡?, Rajeshri G. Karki*‡?, Emma Cody‡, Qian Liu‡, Guiqing Liang‡, Gary M. Ksander‡†, Dean F. Rigel?#, Nikolaus Schiering§, Yongjin Gong‡¥, Gary M. Coppola‡, Yuki Iwaki‡¶, Robert Sun‡?, Alan Neubert‡, Li Fan‡, Sa Source Type: research

[ASAP] Novel < italic toggle="yes" > N < /italic > -Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00549 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 31, 2020 Category: Chemistry Authors: Lorella Pasquinucci †, Carmela Parenti*‡, M. Carmen Ruiz-Cantero§?, Zafiroula Georgoussi?, Paschalina Pallaki?, Enrique J. Cobos§?, Emanuele Amata†, Agostino Marrazzo†, Orazio Prezzavento†, Emanuela Arena†, Maria Dichiara†, Loredana Salern Source Type: research

[ASAP] A Class of Potent Inhibitors of the HIV-1 Nucleocapsid Protein Based on Aminopyrrolic Scaffolds
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00558 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 31, 2020 Category: Chemistry Authors: Stefano Ciaco †?#, Nicolas Humbert†#, Ele´onore Real†#, Christian Boudier†, Oscar Francesconi‡, Stefano Roelens‡, Cristina Nativi‡, Carole Seguin-Devaux§, Mattia Mori*?, and Yves Me´ly*† Source Type: research

[ASAP] Simple FRET Electrophoresis Method for Precise and Dynamic Evaluation of Serum siRNA Stability
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00472 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 30, 2020 Category: Chemistry Authors: Martina Tuttolomondo* † and Henrik J. Ditzel*†‡ Source Type: research

[ASAP] Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00480 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 30, 2020 Category: Chemistry Authors: Jean-Marc M. Grandjean †, Alexander Y. Jiu†, John W. West†, Atsushi Aoyagi‡, Daniel G. Droege†, Manuel Elepano†, Makoto Hirasawa‡, Masakazu Hirouchi‡, Ryo Murakami‡, Joanne Lee†, Koji Sasaki‡, Shimpei Hirano‡, Takao Ohyama‡, Benj Source Type: research

[ASAP] Synthesis, Antiproliferative Effect, and Topoisomerase II Inhibitory Activity of 3-Methyl-2-phenyl-1 < italic toggle="yes" > H < /italic > -indoles
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00557 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 29, 2020 Category: Chemistry Authors: Nace Zidar †, Daniela Secci†, Tihomir Tomas?ic?†, Lucija Peterlin Mas?ic?†, Danijel Kikelj†, Daniele Passarella‡, Aida Nelly Garcia Argaez§, Mariafrancesca Hyeraci§, and Lisa Dalla Via*§ Source Type: research

[ASAP] Peptides Mimicking the ß7/ß8 Loop of HIV-1 Reverse Transcriptase p51 as “Hotspot-Targeted” Dimerization Inhibitors
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00623 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 28, 2020 Category: Chemistry Authors: Pedro A. Sa ´nchez-Murcia†?, Sonia de Castro†, Carlos Garci´a-Aparicio†, M. Angeles Jime´nez‡, Angela Corona§, Enzo Tramontano§, Nicolas Sluis-Cremer?, Luis Mene´ndez-Arias?, Sonsoles Vela´zquez†, Federico Gago*#, and Mari´a-Jose´ Camar Source Type: research

[ASAP] Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00572 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 27, 2020 Category: Chemistry Authors: Christoph Steeneck*, Olaf Kinzel, Simon Anderhub, Martin Hornberger, Sheena Pinto, Barbara Morschhaeuser, Floriane Braun, Gerald Kleymann, and Thomas Hoffmann Source Type: research

[ASAP] BRM Targeting Compounds for the Potential Treatment of Cancer
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00007 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 24, 2020 Category: Chemistry Authors: Robert B. Kargbo* Source Type: research

[ASAP] Do We Build Similar Molecules for Comorbid Diseases? < italic toggle="yes" > Tevarud < /italic > in Drug Design, an Analysis for Depression and Inflammation
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00519 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 22, 2020 Category: Chemistry Authors: F. Esra O ¨nen Bayram*†, Sarah A. A. Alradhwani†, Gulcin Tugcu‡, and Hande Sipahi‡ Source Type: research

[ASAP] Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00453 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 22, 2020 Category: Chemistry Authors: Baljinder Singh †, Jean A. Bernatchez‡, Laura-Isobel McCall‡, Claudia M. Calvet‡, Jasmin Ackermann‡, Julia M. Souza‡, Diane Thomas‡, Everton M. Silva‡, Kelly A. Bachovchin†, Dana M. Klug†, Hitesh B. Jalani†, Seema Bag†, Melissa J. Source Type: research

[ASAP] Structure –Bioactivity Relationships of Lapatinib Derived Analogs against < italic toggle="yes" > Schistosoma mansoni < /italic >
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00455 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 22, 2020 Category: Chemistry Authors: Melissa J. Buskes †, Monica Clements†?, Kelly A. Bachovchin†, Hitesh B. Jalani†, Allison Leonard†, Seema Bag†, Dana M. Klug†, Baljinder Singh†, Robert F. Campbell‡, Richard J. Sciotti‡, Nelly El-Sakkary§, Conor R. Caffrey*§, Michael Source Type: research

[ASAP] Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00560 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 21, 2020 Category: Chemistry Authors: Sida Shen ‡?, Michal Svoboda§, Guangming Zhang?, Maria A. Cavasin?#, Lucia Motlova§, Timothy A. McKinsey?#, James H. Eubanks?, Cyril Bar?inka§, and Alan P. Kozikowski*† Source Type: research

[ASAP] Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8 < italic toggle="yes" > S < /italic > Configuration
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00302 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 21, 2020 Category: Chemistry Authors: Tyler A. Johnson* †‡, Joseph D. Morris†?, David A. Coppage‡?, Colon V. Cook†?, Lauren N. Persi†, Marcos A. Ogarrio†, Taylor C. Garcia†, Nicole L. McIntosh†, Erin P. McCauley‡, Joseph Media§, Mani Maheshwari§, Frederick A. Valeriote§ Source Type: research

[ASAP] Discovery of Zika Virus NS2B/NS3 Inhibitors That Prevent Mice from Life-Threatening Infection and Brain Damage
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00405 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 21, 2020 Category: Chemistry Authors: Antonio Coluccia ‡, Michela Puxeddu‡, Marianna Nalli‡, Chih-Ku Wei†, Yu-Hsuan Wufi, Eloise Mastrangelo§8, Tasneem Elamin8, Delia Tarantino§8#, Joachim Jakob Bugert?, Benno Schreiner?, Juliane Nolte?, Frank Schwarze?, Giuseppe La Regina‡, Jin-C Source Type: research

[ASAP] Drug Synergism: Studies of Combination of RK-52 and Curcumin against Rhodesain of < italic toggle="yes" > Trypanosoma brucei rhodesiense < /italic >
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00635 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 17, 2020 Category: Chemistry Authors: Roberta Ettari* †, Santo Previti†, Carla Di Chio†, Santina Maiorana†, Alessandro Allegra‡, Tanja Schirmeister§, and Maria Zappala`† Source Type: research

[ASAP] Discovery of a New Sulfonamide Hepatitis B Capsid Assembly Modulator
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00550 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 15, 2020 Category: Chemistry Authors: Hyo Gyeong Na †‡, Ali Imran†, Kyuneun Kim†‡, Hong Sik Han†‡, Young Jin Lee†‡, Myung-Jin Kim#, Chang-Soo Yun†, Young-Sik Jung†‡, Joo-Youn Lee§, and Soo Bong Han*†‡ Source Type: research

[ASAP] New Chemical Modalities and Strategic Thinking in Early Drug Discovery
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00582 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 14, 2020 Category: Chemistry Authors: Maria-Jesus Blanco* † and Kevin M. Gardinier*‡ Source Type: research

[ASAP] Discovery of < italic toggle="yes" > N < /italic > -(Indazol-3-yl)piperidine-4-carboxylic Acids as ROR?t Allosteric Inhibitors for Autoimmune Diseases
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00431 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 14, 2020 Category: Chemistry Authors: Hongjun Zhang* †, Blair T. Lapointe†, Neville Anthony†, Rita Azevedo?, Jos Cals?, Craig C. Correll‡, Matthew Daniels§, Sujal Deshmukh?, Hans van Eenenaam¶, Heidi Ferguson?, Laxminarayan G. Hegde?, Willem Jan Karstens?, John Maclean#, J. Richard Source Type: research

[ASAP] Structure –Functional–Selectivity Relationship Studies of Novel Apomorphine Analogs to Develop D1R/D2R Biased Ligands
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00575 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 13, 2020 Category: Chemistry Authors: Hyejin Park+ §, Aarti N. Urs‡§, Joseph Zimmerman‡, Chuan Liu+, Qiu Wang*+, and Nikhil M. Urs*‡ Source Type: research

[ASAP] Methyl Scanning and Revised Binding Mode of 2-Pralidoxime, an Antidote for Nerve Agent Poisoning
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00586 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - January 10, 2020 Category: Chemistry Authors: Adriana Gambino, James C. Burnett, and Kazunori Koide* Source Type: research