The Association Between Aspirin Use and Immune-Related Adverse Events in Specific Cancer Patients Receiving ICIs Therapy: Analysis of the FAERS Database
This study analyzed adverse reaction data associated with the use of ICIs in the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database, from the approval date of each drug until October 1, 2022. Multivariate logistic regression was employed to assess the association of aspirin use with irAEs in patients receiving ICIs.The results indicated that aspirin use was associated with an increased risk of irAEs in a pan-cancer analysis, with a more pronounced association in specific cancer types such as lung cancer, mesothelioma, and pancreatic cancer. However, in lymphoma, aspirin use was associated...
Source: Frontiers in Pharmacology - November 15, 2023 Category: Drugs & Pharmacology Source Type: research
Drug-induced cardiac toxicity and adverse drug reactions, a narrative review
Therapie. 2023 Oct 31:S0040-5957(23)00169-5. doi: 10.1016/j.therap.2023.10.008. Online ahead of print.ABSTRACTDrug-induced cardiotoxicity is a primary concern in both drug development and clinical practice. Although the heart is not a common target for adverse drug reactions, some drugs still cause various adverse cardiac events, with sometimes severe consequences. Direct cardiac toxicity encompasses functional and structural changes of the cardiovascular system due to possible exposure to medicines. This phenomenon extends beyond cardiovascular drugs to include non-cardiovascular drugs including anticancer drugs such as t...
Source: Therapie - November 13, 2023 Category: Psychiatry & Psychology Authors: Alexandre Destere Diane Merino Thibaud Lavrut Fanny Rocher Delphine Viard Milou-Daniel Drici Alexandre O G érard Source Type: research
Drug-induced cardiac toxicity and adverse drug reactions, a narrative review
Therapie. 2023 Oct 31:S0040-5957(23)00169-5. doi: 10.1016/j.therap.2023.10.008. Online ahead of print.ABSTRACTDrug-induced cardiotoxicity is a primary concern in both drug development and clinical practice. Although the heart is not a common target for adverse drug reactions, some drugs still cause various adverse cardiac events, with sometimes severe consequences. Direct cardiac toxicity encompasses functional and structural changes of the cardiovascular system due to possible exposure to medicines. This phenomenon extends beyond cardiovascular drugs to include non-cardiovascular drugs including anticancer drugs such as t...
Source: Therapie - November 13, 2023 Category: Psychiatry & Psychology Authors: Alexandre Destere Diane Merino Thibaud Lavrut Fanny Rocher Delphine Viard Milou-Daniel Drici Alexandre O G érard Source Type: research
Dose escalation for stereotactic arrhythmia radioablation of recurrent ventricular tachyarrhythmia - a phase II clinical trial
DISCUSSION: DEFT-STAR is an innovative prospective phase II trial that aims to evaluate the optimal radiation dose for STAR in patients with therapy-refractory sVA. The trial has obtained IRB approval and focuses on determining the safe and effective radiation dose to be employed in the STAR procedure.TRIAL REGISTRATION: NCT05594368.PMID:37941012 | DOI:10.1186/s13014-023-02361-x (Source: Ann Oncol)
Source: Ann Oncol - November 8, 2023 Category: Cancer & Oncology Authors: Boldizsar Kovacs Michael Mayinger Stefanie Ehrbar Debra Fesslmeier Maiwand Ahmadsei Lorraine Sazgary Robert Manka Hatem Alkadhi Frank Ruschitzka Firat Duru Alexandros Papachristofilou Christian Sticherling Slawomir Blamek Krzysztof S Go łba Matthias Guck Source Type: research
Dose escalation for stereotactic arrhythmia radioablation of recurrent ventricular tachyarrhythmia - a phase II clinical trial
DISCUSSION: DEFT-STAR is an innovative prospective phase II trial that aims to evaluate the optimal radiation dose for STAR in patients with therapy-refractory sVA. The trial has obtained IRB approval and focuses on determining the safe and effective radiation dose to be employed in the STAR procedure.TRIAL REGISTRATION: NCT05594368.PMID:37941012 | PMC:PMC10634182 | DOI:10.1186/s13014-023-02361-x (Source: Ann Oncol)
Source: Ann Oncol - November 8, 2023 Category: Cancer & Oncology Authors: Boldizsar Kovacs Michael Mayinger Stefanie Ehrbar Debra Fesslmeier Maiwand Ahmadsei Lorraine Sazgary Robert Manka Hatem Alkadhi Frank Ruschitzka Firat Duru Alexandros Papachristofilou Christian Sticherling Slawomir Blamek Krzysztof S Go łba Matthias Guck Source Type: research
Ocular Whipple Disease: Cases Diagnosed Over Four Decades
CONCLUSIONS: WD is uncommon and ocular involvement is even more rare. However, WD should be considered in the differential for all patients with chronic recalcitrant uveitis, especially in the setting of polyarthralgias and/or gastrointestinal symptoms. Vitreous biopsy is a reliable method to diagnose ocular WD.Abbreviations and Acronyms: Whipple's disease (WD), intestinal lipodystrophy (IL), polymerase-chain reaction (PCR), periodic acid-Schiff (PAS), trimethoprim/sulfamethoxazole (TMP/SMX).PMID:37917881 | DOI:10.1080/09273948.2023.2271995 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - November 2, 2023 Category: Allergy & Immunology Authors: Ali R Salman Diva R Salomao Lauren A Dalvin Timothy W Olsen Wendy M Smith Source Type: research
Molecular Imaging Biomarkers in Cardiooncology: A View on Established Technologies and Future Perspectives
Novel therapeutic options have significantly improved survival and long-term outcomes in many cancer entities. Unfortunately, this improvement in outcome is often accompanied by new and increasingly relevant therapy-related cardiovascular toxicity. In this context, cardiooncology has emerged as a new field of interdisciplinary individual patient care. Important tasks are pretherapeutic risk stratification and early detection and treatment of cardiotoxicity, which comprises cardiac damage in relation to cardiovascular comorbidities, the tumor disease, and cancer treatment. Clinical manifestations can cover a broad spectrum,...
Source: Journal of Nuclear Medicine - November 2, 2023 Category: Nuclear Medicine Authors: Kersting, D., Mavroeidi, I.-A., Settelmeier, S., Seifert, R., Schuler, M., Herrmann, K., Rassaf, T., Rischpler, C. Tags: Clinical Investigations Source Type: research
Further Analysis Needed or Was It Lead Reversal?
To the Editor I read the interesting case report by Xiao and Zhou. It is very unusual for the intense inflammation of acute pericarditis to resolve in 1 area in a few minutes, contrary to what is suggested by Xiao and Zhou. Rather, the inflammation may spread to other areas as mentioned in the case report. As correctly reported by the authors, stage 1 of ST-segment elevation in acute pericarditis persists for at least a few hours. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - October 30, 2023 Category: Internal Medicine Source Type: research
Further Analysis Needed or Was It Lead Reversal —Reply
In Reply We appreciate the letters from Kawji and Chang et al regarding our report of migrating localized ST-segment elevation in the setting of acute pericarditis. In response to Kawji ’s comments, we agree that the ST-segment dynamic change in this case was fast. This was seen on the repeated electrocardiogram (ECG) in the emergency department (Figure, B), obtained 25 minutes after the first ECG by emergency medical services (Figure, A). It continued to evolve with migrating ST -segment elevation in localization as seen on the third ECG (Figure, C) obtained 88 minutes after the first ECG, and was followed by diffuse ST...
Source: JAMA Internal Medicine - October 30, 2023 Category: Internal Medicine Source Type: research
Adjunctive Corticosteroid Therapy for severe tuberculosis: Risk factors for poor outcomes?
Conclusion: Adjunctive corticosteroid therapy appears to offer significant short-term but (other than for tuberculous meningitis and effusive pericarditis) minimal long-term benefit for patients with tuberculosis. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Nour Lahbib, J., Amani, B. M., Azza, S., Soumaya, B. S., Hafaoua, D., Fatma, T. Tags: Tuberculosis and non-tuberculous mycobacterial diseases Source Type: research
ST-Segment Elevation Myocardial Infarction and Bleeding Complications in JAK2-Negative Polycythemia
Tex Heart Inst J. 2023 Oct 20;50(5):e238148. doi: 10.14503/THIJ-23-8148.ABSTRACTThrombotic and bleeding complications are major causes of morbidity and mortality in patients with polycythemia vera, who predominantly present with an alteration in the JAK2 gene. Because of their hypercoagulable state and risk of hemorrhage, patients with polycythemia vera who present with an acute myocardial infarction pose a challenge to physicians. This case report describes the presentation and treatment of a Hispanic patient with JAK2 V617F-negative primary polycythemia who developed cardiac arrest and ST-segment elevation myocardial inf...
Source: Texas Heart Institute Journal - October 24, 2023 Category: Cardiology Authors: Priscilla Duran Luciano Vanessa Sabella-Jim énez Source Type: research
ST-Segment Elevation Myocardial Infarction and Bleeding Complications in JAK2-Negative Polycythemia
Tex Heart Inst J. 2023 Oct 20;50(5):e238148. doi: 10.14503/THIJ-23-8148.ABSTRACTThrombotic and bleeding complications are major causes of morbidity and mortality in patients with polycythemia vera, who predominantly present with an alteration in the JAK2 gene. Because of their hypercoagulable state and risk of hemorrhage, patients with polycythemia vera who present with an acute myocardial infarction pose a challenge to physicians. This case report describes the presentation and treatment of a Hispanic patient with JAK2 V617F-negative primary polycythemia who developed cardiac arrest and ST-segment elevation myocardial inf...
Source: Texas Heart Institute Journal - October 24, 2023 Category: Cardiology Authors: Priscilla Duran Luciano Vanessa Sabella-Jim énez Source Type: research
Safety and Efficacy of Colchicine for the Prevention of Pericarditis in Patients Who Underwent Catheter Ablation for Atrial Fibrillation
Acute pericarditis is common in patients who underwent catheter ablation for atrial fibrillation (AF) with a reported incidence of 0.5% to 10.2%.1 The underlying mechanism is believed to be an inflammatory reaction triggered by injury to the pericardial tissue during the ablation.2 Colchicine is an anti-inflammatory drug that has been evaluated in different studies for the prevention of pericarditis in patients who underwent catheter ablation for AF.2 –5 However, these studies have shown inconsistent and conflicting results likely related to small sample size and heterogeneous study end points. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - October 18, 2023 Category: Cardiology Authors: Siddharth Agarwal, Laila Hashim, Sunny Po, Zain Ul Abideen Asad Tags: Brief report Source Type: research
Pyothorax and Constrictive Pericarditis after Chemoradiotherapy for Esophageal Cancer: A Case Report
Intern Med. 2023 Oct 13. doi: 10.2169/internalmedicine.2502-23. Online ahead of print.ABSTRACTA 75-year-old man underwent chemoradiotherapy for advanced esophageal cancer. After nine years, he was hospitalized for left pyothorax. Consequently, the patient underwent drainage and window opening surgery. He experienced cardiopulmonary arrest but was resuscitated. Based on cardiac catheterization data, the patient was diagnosed with constrictive pericarditis. Unfortunately, extracorporeal circulation did not improve his condition, and he ultimately died. An autopsy revealed adhesion between the pericardium and pleura, especial...
Source: Internal Medicine - October 15, 2023 Category: Internal Medicine Authors: Yohei Ishibashi Noriaki Takama Yoichi Ohtaki Norimichi Koitabashi Masahiko Kurabayashi Hideki Ishii Source Type: research
