Immune checkpoint inhibitors associated cardiovascular immune-related adverse events
Front Immunol. 2024 Feb 5;15:1340373. doi: 10.3389/fimmu.2024.1340373. eCollection 2024.ABSTRACTImmune checkpoint inhibitors (ICIs) are specialized monoclonal antibodies (mAbs) that target immune checkpoints and their ligands, counteracting cancer cell-induced T-cell suppression. Approved ICIs like cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1), its ligand PD-L1, and lymphocyte activation gene-3 (LAG-3) have improved cancer patient outcomes by enhancing anti-tumor responses. However, some patients are unresponsive, and others experience immune-related adverse events (irAEs), affecting organs like the ...
Source: Atherosclerosis - February 20, 2024 Category: Cardiology Authors: Wonyoung Jo Taejoon Won Abdel Daoud Daniela Čiháková Source Type: research
Immune checkpoint inhibitors associated cardiovascular immune-related adverse events
Front Immunol. 2024 Feb 5;15:1340373. doi: 10.3389/fimmu.2024.1340373. eCollection 2024.ABSTRACTImmune checkpoint inhibitors (ICIs) are specialized monoclonal antibodies (mAbs) that target immune checkpoints and their ligands, counteracting cancer cell-induced T-cell suppression. Approved ICIs like cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1), its ligand PD-L1, and lymphocyte activation gene-3 (LAG-3) have improved cancer patient outcomes by enhancing anti-tumor responses. However, some patients are unresponsive, and others experience immune-related adverse events (irAEs), affecting organs like the ...
Source: Atherosclerosis - February 20, 2024 Category: Cardiology Authors: Wonyoung Jo Taejoon Won Abdel Daoud Daniela Čiháková Source Type: research
An updated analysis on myocarditis and pericarditis cases reported following mRNA SARS-CoV-2 vaccination in Singapore
CONCLUSIONS: The risk of myocarditis/pericarditis with mRNA vaccines was highest in adolescent males following Dose 2, and this was higher than historically observed background rates. Most cases were clinically mild. The risk of myocarditis should be weighed against the benefits of receiving an mRNA vaccine, keeping in mind that SARS-CoV-2 infections carry substantial risks of myocarditis/pericarditis, as well as the evolving landscape of the disease.PMID:38363732 | DOI:10.4103/singaporemedj.SMJ-2023-089 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - February 16, 2024 Category: General Medicine Authors: Mun Yee Tham Cheng Leng Chan Dorothy Toh Jalene Poh Adena Lim Sally Soh Li Fung Peck Belinda Foo Amelia Ng Patricia Ng Pei San Ang Sreemanee Dorajoo Desmond Teo Toon Wei Lim Yean Teng Lim Jonathan Choo Zee Pin Ding Khung Keong Yeo Jonathan Yap Hui Xing Ta Source Type: research
An updated analysis on myocarditis and pericarditis cases reported following mRNA SARS-CoV-2 vaccination in Singapore
CONCLUSIONS: The risk of myocarditis/pericarditis with mRNA vaccines was highest in adolescent males following Dose 2, and this was higher than historically observed background rates. Most cases were clinically mild. The risk of myocarditis should be weighed against the benefits of receiving an mRNA vaccine, keeping in mind that SARS-CoV-2 infections carry substantial risks of myocarditis/pericarditis, as well as the evolving landscape of the disease.PMID:38363732 | DOI:10.4103/singaporemedj.SMJ-2023-089 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - February 16, 2024 Category: General Medicine Authors: Mun Yee Tham Cheng Leng Chan Dorothy Toh Jalene Poh Adena Lim Sally Soh Li Fung Peck Belinda Foo Amelia Ng Patricia Ng Pei San Ang Sreemanee Dorajoo Desmond Teo Toon Wei Lim Yean Teng Lim Jonathan Choo Zee Pin Ding Khung Keong Yeo Jonathan Yap Hui Xing Ta Source Type: research
An updated analysis on myocarditis and pericarditis cases reported following mRNA SARS-CoV-2 vaccination in Singapore
CONCLUSIONS: The risk of myocarditis/pericarditis with mRNA vaccines was highest in adolescent males following Dose 2, and this was higher than historically observed background rates. Most cases were clinically mild. The risk of myocarditis should be weighed against the benefits of receiving an mRNA vaccine, keeping in mind that SARS-CoV-2 infections carry substantial risks of myocarditis/pericarditis, as well as the evolving landscape of the disease.PMID:38363732 | DOI:10.4103/singaporemedj.SMJ-2023-089 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - February 16, 2024 Category: General Medicine Authors: Mun Yee Tham Cheng Leng Chan Dorothy Toh Jalene Poh Adena Lim Sally Soh Li Fung Peck Belinda Foo Amelia Ng Patricia Ng Pei San Ang Sreemanee Dorajoo Desmond Teo Toon Wei Lim Yean Teng Lim Jonathan Choo Zee Pin Ding Khung Keong Yeo Jonathan Yap Hui Xing Ta Source Type: research
An updated analysis on myocarditis and pericarditis cases reported following mRNA SARS-CoV-2 vaccination in Singapore
CONCLUSIONS: The risk of myocarditis/pericarditis with mRNA vaccines was highest in adolescent males following Dose 2, and this was higher than historically observed background rates. Most cases were clinically mild. The risk of myocarditis should be weighed against the benefits of receiving an mRNA vaccine, keeping in mind that SARS-CoV-2 infections carry substantial risks of myocarditis/pericarditis, as well as the evolving landscape of the disease.PMID:38363732 | DOI:10.4103/singaporemedj.SMJ-2023-089 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - February 16, 2024 Category: General Medicine Authors: Mun Yee Tham Cheng Leng Chan Dorothy Toh Jalene Poh Adena Lim Sally Soh Li Fung Peck Belinda Foo Amelia Ng Patricia Ng Pei San Ang Sreemanee Dorajoo Desmond Teo Toon Wei Lim Yean Teng Lim Jonathan Choo Zee Pin Ding Khung Keong Yeo Jonathan Yap Hui Xing Ta Source Type: research
An updated analysis on myocarditis and pericarditis cases reported following mRNA SARS-CoV-2 vaccination in Singapore
CONCLUSIONS: The risk of myocarditis/pericarditis with mRNA vaccines was highest in adolescent males following Dose 2, and this was higher than historically observed background rates. Most cases were clinically mild. The risk of myocarditis should be weighed against the benefits of receiving an mRNA vaccine, keeping in mind that SARS-CoV-2 infections carry substantial risks of myocarditis/pericarditis, as well as the evolving landscape of the disease.PMID:38363732 | DOI:10.4103/singaporemedj.SMJ-2023-089 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - February 16, 2024 Category: General Medicine Authors: Mun Yee Tham Cheng Leng Chan Dorothy Toh Jalene Poh Adena Lim Sally Soh Li Fung Peck Belinda Foo Amelia Ng Patricia Ng Pei San Ang Sreemanee Dorajoo Desmond Teo Toon Wei Lim Yean Teng Lim Jonathan Choo Zee Pin Ding Khung Keong Yeo Jonathan Yap Hui Xing Ta Source Type: research
An updated analysis on myocarditis and pericarditis cases reported following mRNA SARS-CoV-2 vaccination in Singapore
CONCLUSIONS: The risk of myocarditis/pericarditis with mRNA vaccines was highest in adolescent males following Dose 2, and this was higher than historically observed background rates. Most cases were clinically mild. The risk of myocarditis should be weighed against the benefits of receiving an mRNA vaccine, keeping in mind that SARS-CoV-2 infections carry substantial risks of myocarditis/pericarditis, as well as the evolving landscape of the disease.PMID:38363732 | DOI:10.4103/singaporemedj.SMJ-2023-089 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - February 16, 2024 Category: General Medicine Authors: Mun Yee Tham Cheng Leng Chan Dorothy Toh Jalene Poh Adena Lim Sally Soh Li Fung Peck Belinda Foo Amelia Ng Patricia Ng Pei San Ang Sreemanee Dorajoo Desmond Teo Toon Wei Lim Yean Teng Lim Jonathan Choo Zee Pin Ding Khung Keong Yeo Jonathan Yap Hui Xing Ta Source Type: research
An updated analysis on myocarditis and pericarditis cases reported following mRNA SARS-CoV-2 vaccination in Singapore
CONCLUSIONS: The risk of myocarditis/pericarditis with mRNA vaccines was highest in adolescent males following Dose 2, and this was higher than historically observed background rates. Most cases were clinically mild. The risk of myocarditis should be weighed against the benefits of receiving an mRNA vaccine, keeping in mind that SARS-CoV-2 infections carry substantial risks of myocarditis/pericarditis, as well as the evolving landscape of the disease.PMID:38363732 | DOI:10.4103/singaporemedj.SMJ-2023-089 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - February 16, 2024 Category: General Medicine Authors: Mun Yee Tham Cheng Leng Chan Dorothy Toh Jalene Poh Adena Lim Sally Soh Li Fung Peck Belinda Foo Amelia Ng Patricia Ng Pei San Ang Sreemanee Dorajoo Desmond Teo Toon Wei Lim Yean Teng Lim Jonathan Choo Zee Pin Ding Khung Keong Yeo Jonathan Yap Hui Xing Ta Source Type: research
An updated analysis on myocarditis and pericarditis cases reported following mRNA SARS-CoV-2 vaccination in Singapore
CONCLUSIONS: The risk of myocarditis/pericarditis with mRNA vaccines was highest in adolescent males following Dose 2, and this was higher than historically observed background rates. Most cases were clinically mild. The risk of myocarditis should be weighed against the benefits of receiving an mRNA vaccine, keeping in mind that SARS-CoV-2 infections carry substantial risks of myocarditis/pericarditis, as well as the evolving landscape of the disease.PMID:38363732 | DOI:10.4103/singaporemedj.SMJ-2023-089 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - February 16, 2024 Category: General Medicine Authors: Mun Yee Tham Cheng Leng Chan Dorothy Toh Jalene Poh Adena Lim Sally Soh Li Fung Peck Belinda Foo Amelia Ng Patricia Ng Pei San Ang Sreemanee Dorajoo Desmond Teo Toon Wei Lim Yean Teng Lim Jonathan Choo Zee Pin Ding Khung Keong Yeo Jonathan Yap Hui Xing Ta Source Type: research
COVID-19 vaccines and adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals
CONCLUSION: This multi-country analysis confirmed pre-established safety signals for myocarditis, pericarditis, Guillain-Barré syndrome, and cerebral venous sinus thrombosis. Other potential safety signals that require further investigation were identified.PMID:38350768 | DOI:10.1016/j.vaccine.2024.01.100 (Source: Vaccine)
Source: Vaccine - February 13, 2024 Category: Allergy & Immunology Authors: K Faksova D Walsh Y Jiang J Griffin A Phillips A Gentile J C Kwong K Macartney M Naus Z Grange S Escolano G Sepulveda A Shetty A Pillsbury C Sullivan Z Naveed N Z Janjua N Giglio J Per älä S Nasreen H Gidding P Hovi T Vo F Cui L Deng L Cullen M Artama E Source Type: research
Assessing the temporal and cause-effect relationship between myocarditis and mRNA COVID-19 vaccines. A retrospective observational study.
Myocarditis is an inflammation of the heart muscle, and if it is accompanied by pericarditis, it is referred to as myopericarditis; in both cases, the body's immune system is causing inflammation in response to an infection or some other trigger. According to the US Centers for Disease Control and Prevention (CDC), the term “myocarditis” refers to myocarditis, pericarditis, or myopericarditis [1]. Myocarditis typically occurs more commonly in males than females, and the incidence is highest among infants, adolescents, and young adults [2–4]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 13, 2024 Category: Infectious Diseases Authors: Francesco Paolo Bianchi, Donato Rizzi, Antonio Daleno, Pasquale Stefanizzi, Giovanni Migliore, Silvio Tafuri Source Type: research
The clinical value of P-wave terminal force in lead V1 in evaluating pericardial thickness in tuberculous constrictive pericarditis
To investigate the relationship between p wave terminal force (Ptfv1) and pericardial thickness in patients with tuberculous constrictive pericarditis. (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - February 12, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Yanhong Ren Tags: Research Source Type: research
Pericardiectomy and Mechanical Mitro-Aortic Valve Replacement in a Young Patient With Erdheim-Chester Disease
This report presents the case of a young patient with constrictive pericarditis and mitral valve regurgitation resulting from Erdheim-Chester disease.PMID:38321789 | DOI:10.14503/THIJ-23-8201 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - February 7, 2024 Category: Cardiology Authors: Nerea Lopez Perez Mathieu van Steenberghe J örg D Seebach Philippe Meyer Johannes Alexander Lobrinus Christoph Huber Mustafa Cikirikcioglu Source Type: research
Persistent convex ST ‐segment elevation in a patient with a history of prior intracerebral haemorrhage
AbstractManagement of patients with acute chest pain poses a significant challenge in identifying those requiring urgent coronary reperfusion. Electrocardiogram (ECG) constitutes the cornerstone in making prompt clinical decisions by identifying ST-segment elevation, commonly associated with ST-segment elevation myocardial infarction. It is important to note that ST-segment elevation can also be a manifestation of various cardiac and non-cardiac conditions, from acute myocarditis, early repolarization syndrome, acute pericarditis, and left bundle branch block to unknown origins. The similarity of ECG changes among these co...
Source: ESC Heart Failure - February 7, 2024 Category: Cardiology Authors: Jian Jiang,
Chengjiang Jin,
Shuo Yu,
Yunxian Cheng,
Yinggang Wu,
Hong Ma Tags: Case Report Source Type: research
