Perioperative Cefazolin for Total Joint Arthroplasty Patients Who Have a Penicillin Allergy: Is it Safe?
Cefazolin is the standard of care for perioperative antibiotic prophylaxis in total joint arthroplasty (TJA) in the United States. The potential allergic cross-reactivity between cefazolin and penicillin causes uncertainty regarding optimal antibiotic choice in patients who have a reported penicillin allergy (rPCNA). The purpose of this study was to determine the safety of perioperative cefazolin in PCNA patients undergoing primary TJA. (Source: The Journal of Arthroplasty)
Source: The Journal of Arthroplasty - April 25, 2024 Category: Orthopaedics Authors: Brandon R. Bukowski, Ricardo J. Torres-Ramirez, Daniel Devine, Yu-Fen Chiu, Alberto V. Carli, Daniel B. Maalouf, Enrique A. Goytizolo, Andy O. Miller, Jose A. Rodriguez Tags: 2023 AAHKS Proceedings Source Type: research
Isolation and Identification of < em > Pasteurella multocida < /em > and < em > Mannheimia haemolytica < /em > from Pneumonic Small Ruminants and Their Antibiotic Susceptibility in Haramaya District, Eastern Ethiopia
CONCLUSION: This study showed that M. haemolytica and P. multocida are the common causes of mannheimiosis and pasteurellosis in small ruminants, respectively, and isolates were resistant to commonly used antibiotics in the study area. Thus, an integrated vaccination strategy, antimicrobial resistance monitoring, and avoidance of stress-inducing factors are recommended.PMID:38655561 | PMC:PMC11039012 | DOI:10.1155/2024/5605552 (Source: The Scientific World Journal)
Source: The Scientific World Journal - April 24, 2024 Category: Science Authors: Mohammed Abdulkadir Taju Nigussie Isayas Asefa Kebede Source Type: research
Genes, Vol. 15, Pages 532: Resistome, Virulome, and Clonal Variation in Methicillin-Resistant Staphylococcus aureus (MRSA) in Healthy Swine Populations: A Cross-Sectional Study
Patricia Poeta
This cross-sectional study investigates the methicillin-resistant Staphylococcus aureus (MRSA): its prevalence, antimicrobial resistance, and molecular characteristics in healthy swine populations in central Portugal. A total of 213 samples were collected from pigs on twelve farms, and MRSA prevalence was assessed using selective agar plates and confirmed via molecular methods. Antimicrobial susceptibility testing and whole genome sequencing (WGS) were performed to characterize resistance profiles and genetic determinants. Among the 107 MRSA-positive samples (83.1% prevalence), fattening pigs and breed...
Source: Genes - April 24, 2024 Category: Genetics & Stem Cells Authors: Vanessa Silva Adriana Silva Raquel Barbero Mario Romero Rosa del Campo Manuela Cani ça Rui Cordeiro Gilberto Igrejas Patricia Poeta Tags: Article Source Type: research
Characterization of Ceftriaxone-Resistant < em > Haemophilus influenzae < /em > Among Korean Children
CONCLUSION: The emergence of ceftriaxone-resistant H. influenzae with ceftriaxone MIC values of up to 0.75 mg/L was observed even in children in South Korea, with most associated with S385T and L389F substitutions. The N526K mutation alone does not significantly impact ceftriaxone resistance. Further large-scale studies are essential to investigate changes in antibiotic resistance patterns and factors influencing antibiotic resistance in H. influenzae isolated from pediatric patients in Korea.PMID:38651222 | DOI:10.3346/jkms.2024.39.e136 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 23, 2024 Category: Biomedical Science Authors: Sanghoon Lee Gahee Kim Jung Hwa Kim Mi-Na Kim Jina Lee Source Type: research
Identification of small molecule inhibitors of penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus for the therapeutics of bacterial infection
In conclusion, the results suggest alpha-mangostin as a promising candidate for inhibiting PBP2a. Further, extensive studies are warranted to explore its clinical applications.PMID:38650157 | DOI:10.14715/cmb/2024.70.3.6 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Anwer Razique Source Type: research
Characterization of Ceftriaxone-Resistant < em > Haemophilus influenzae < /em > Among Korean Children
CONCLUSION: The emergence of ceftriaxone-resistant H. influenzae with ceftriaxone MIC values of up to 0.75 mg/L was observed even in children in South Korea, with most associated with S385T and L389F substitutions. The N526K mutation alone does not significantly impact ceftriaxone resistance. Further large-scale studies are essential to investigate changes in antibiotic resistance patterns and factors influencing antibiotic resistance in H. influenzae isolated from pediatric patients in Korea.PMID:38651222 | DOI:10.3346/jkms.2024.39.e136 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 23, 2024 Category: General Medicine Authors: Sanghoon Lee Gahee Kim Jung Hwa Kim Mi-Na Kim Jina Lee Source Type: research
Identification of small molecule inhibitors of penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus for the therapeutics of bacterial infection
In conclusion, the results suggest alpha-mangostin as a promising candidate for inhibiting PBP2a. Further, extensive studies are warranted to explore its clinical applications.PMID:38650157 | DOI:10.14715/cmb/2024.70.3.6 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 23, 2024 Category: Molecular Biology Authors: Anwer Razique Source Type: research
Characterization of Ceftriaxone-Resistant < em > Haemophilus influenzae < /em > Among Korean Children
CONCLUSION: The emergence of ceftriaxone-resistant H. influenzae with ceftriaxone MIC values of up to 0.75 mg/L was observed even in children in South Korea, with most associated with S385T and L389F substitutions. The N526K mutation alone does not significantly impact ceftriaxone resistance. Further large-scale studies are essential to investigate changes in antibiotic resistance patterns and factors influencing antibiotic resistance in H. influenzae isolated from pediatric patients in Korea.PMID:38651222 | DOI:10.3346/jkms.2024.39.e136 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 23, 2024 Category: Biomedical Science Authors: Sanghoon Lee Gahee Kim Jung Hwa Kim Mi-Na Kim Jina Lee Source Type: research
Identification of small molecule inhibitors of penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus for the therapeutics of bacterial infection
In conclusion, the results suggest alpha-mangostin as a promising candidate for inhibiting PBP2a. Further, extensive studies are warranted to explore its clinical applications.PMID:38650157 | DOI:10.14715/cmb/2024.70.3.6 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Anwer Razique Source Type: research
Characterization of Ceftriaxone-Resistant < em > Haemophilus influenzae < /em > Among Korean Children
CONCLUSION: The emergence of ceftriaxone-resistant H. influenzae with ceftriaxone MIC values of up to 0.75 mg/L was observed even in children in South Korea, with most associated with S385T and L389F substitutions. The N526K mutation alone does not significantly impact ceftriaxone resistance. Further large-scale studies are essential to investigate changes in antibiotic resistance patterns and factors influencing antibiotic resistance in H. influenzae isolated from pediatric patients in Korea.PMID:38651222 | DOI:10.3346/jkms.2024.39.e136 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 23, 2024 Category: General Medicine Authors: Sanghoon Lee Gahee Kim Jung Hwa Kim Mi-Na Kim Jina Lee Source Type: research
Low Back Pain in Children, CVD and Obstetric History, Sarcoidosis, Penicillin Allergies, Myocardial Infarction, Venous Ulcers
Am Fam Physician. 2024 Apr;109(4):312.NO ABSTRACTPMID:38648827 (Source: Pain Physician)
Source: Pain Physician - April 22, 2024 Category: Anesthesiology Source Type: research
Streptococcal Pharyngitis: Rapid Evidence Review
Am Fam Physician. 2024 Apr;109(4):343-349.ABSTRACTGroup A beta-hemolytic streptococcal pharyngitis is a common infection responsible for more than 6 million office visits in the United States annually. Only 10% of adults seeking care for a sore throat have group A beta-hemolytic streptococcal pharyngitis; however, 60% or more are prescribed antibiotics. Guidelines recommend using clinical decision rules to assess the risk of group A beta-hemolytic streptococcal infection, followed by rapid antigen testing if a diagnosis is unclear, before prescribing antibiotics. Fever, tonsillar exudate, cervical lymphadenitis, and patien...
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Jennifer L Hamilton Leon McCrea Ii Source Type: research
Low Back Pain in Children, CVD and Obstetric History, Sarcoidosis, Penicillin Allergies, Myocardial Infarction, Venous Ulcers
Am Fam Physician. 2024 Apr;109(4):312.NO ABSTRACTPMID:38648827 (Source: American Family Physician)
Source: American Family Physician - April 22, 2024 Category: Primary Care Source Type: research
Streptococcal Pharyngitis: Rapid Evidence Review
Am Fam Physician. 2024 Apr;109(4):343-349.ABSTRACTGroup A beta-hemolytic streptococcal pharyngitis is a common infection responsible for more than 6 million office visits in the United States annually. Only 10% of adults seeking care for a sore throat have group A beta-hemolytic streptococcal pharyngitis; however, 60% or more are prescribed antibiotics. Guidelines recommend using clinical decision rules to assess the risk of group A beta-hemolytic streptococcal infection, followed by rapid antigen testing if a diagnosis is unclear, before prescribing antibiotics. Fever, tonsillar exudate, cervical lymphadenitis, and patien...
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Jennifer L Hamilton Leon McCrea Ii Source Type: research
