Polyethylene glycol hypersensitivity, patient outcomes in a seven year retrospective study
CONCLUSION: PEG hypersensitivity is an uncommon cause of drug-induced anaphylaxis. Four index drugs accounted for two-thirds of cases and reactions to these drugs should prompt PEG hypersensitivity investigations. PEG IDT increases diagnostic yield. The role of SPT with higher MW PEGs requires further attention. Further studies are required to understand PEG thresholds and PEG equivalent doses of various administration routes. COVID-19 vaccines were tolerated by all exposed.PMID:38561050 | DOI:10.1016/j.anai.2024.03.022 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Oyindamola Stephanie Kayode Alla Nakonechna Leonard Quok Chean Siew Magdalena Dziadzio Lucinda Kennard Krzysztof Rutkowski Rita Mirakian Annette Wagner Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
