Design, synthesis and antibacterial evaluation of low toxicity amphiphilic-cephalosporin derivatives
In this study, two series of amphiphilic-cephalosporins were designed and synthesized, several of which showed good antibacterial activity against both Gram-positive and Gram-negative bacteria. Structure-activity relationships indicated that the length of the hydrophobic alkyl chain significantly affects the antibacterial activity against Gram-negative bacteria. The best compound 2d showed high activity against drug-susceptible Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) with MICs of 0.5 and 2-4 μg/mL, respectively. Furthermore, 2d remained active in complex mammalian body fluids and had a...
Source: European Journal of Medicinal Chemistry - March 6, 2024 Category: Chemistry Authors: Shengcong Chen Shangshang Qin Ruirui Li Ye Qu Maxwell Ampomah-Wireko Lauraine Nininahazwe Meng Wang Chen Gao En Zhang Source Type: research
Plasmid-free cheater cells commonly evolve during laboratory growth
Appl Environ Microbiol. 2024 Mar 6:e0231123. doi: 10.1128/aem.02311-23. Online ahead of print.ABSTRACTIt has been nearly a century since the isolation and use of penicillin, heralding the discovery of a wide range of different antibiotics. In addition to clinical applications, such antibiotics have been essential laboratory tools, allowing for selection and maintenance of laboratory plasmids that encode cognate resistance genes. However, antibiotic resistance mechanisms can additionally function as public goods. For example, extracellular beta-lactamases produced by resistant cells that subsequently degrade penicillin and ...
Source: Applied and Environmental Microbiology - March 6, 2024 Category: Microbiology Authors: Amber M Bedore Christopher M Waters Source Type: research
Design, synthesis and antibacterial evaluation of low toxicity amphiphilic-cephalosporin derivatives
In this study, two series of amphiphilic-cephalosporins were designed and synthesized, several of which showed good antibacterial activity against both Gram-positive and Gram-negative bacteria. Structure-activity relationships indicated that the length of the hydrophobic alkyl chain significantly affects the antibacterial activity against Gram-negative bacteria. The best compound 2d showed high activity against drug-susceptible Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) with MICs of 0.5 and 2-4 μg/mL, respectively. Furthermore, 2d remained active in complex mammalian body fluids and had a...
Source: European Journal of Medicinal Chemistry - March 6, 2024 Category: Chemistry Authors: Shengcong Chen Shangshang Qin Ruirui Li Ye Qu Maxwell Ampomah-Wireko Lauraine Nininahazwe Meng Wang Chen Gao En Zhang Source Type: research
Plasmid-free cheater cells commonly evolve during laboratory growth
Appl Environ Microbiol. 2024 Mar 6:e0231123. doi: 10.1128/aem.02311-23. Online ahead of print.ABSTRACTIt has been nearly a century since the isolation and use of penicillin, heralding the discovery of a wide range of different antibiotics. In addition to clinical applications, such antibiotics have been essential laboratory tools, allowing for selection and maintenance of laboratory plasmids that encode cognate resistance genes. However, antibiotic resistance mechanisms can additionally function as public goods. For example, extracellular beta-lactamases produced by resistant cells that subsequently degrade penicillin and ...
Source: Applied and Environmental Microbiology - March 6, 2024 Category: Microbiology Authors: Amber M Bedore Christopher M Waters Source Type: research
Antimicrobial resistance and public and animal health risks associated with pathogenic Escherichia coli isolated from calves
Comp Immunol Microbiol Infect Dis. 2024 Feb 19;107:102149. doi: 10.1016/j.cimid.2024.102149. Online ahead of print.ABSTRACTWe aimed to determine the antimicrobial susceptibility profile of pathogenic Escherichia coli strains isolated from fecal samples of calves and buffalo calves (2008-2013), in Minas Gerais, Brazil, as well as the frequency of O157 gene and strains carrying extended-spectrum beta-lactamases (ESBL) and mobile colistin resistance (mcr) genes. E. coli strains (n=518) were tested for susceptibility against ten antimicrobials. Tetracycline was the antimicrobial with the highest resistance rate (382/518), foll...
Source: Comparative immunology, microbiology and infectious diseases. - March 5, 2024 Category: Allergy & Immunology Authors: Dirc éia Aparecida da Costa Custódio Carine Rodrigues Pereira Maysa Serpa Gon çalves Anna Cec ília Trolesi Reis Borges Costa Pedro Felipe Rodrigues de Oliveira Bruna Henrique Pinto da Silva Giovanna Botelho Carneiro Fernanda Morcatti Coura Andrey Pere Source Type: research
Antimicrobial resistance and public and animal health risks associated with pathogenic Escherichia coli isolated from calves
Comp Immunol Microbiol Infect Dis. 2024 Feb 19;107:102149. doi: 10.1016/j.cimid.2024.102149. Online ahead of print.ABSTRACTWe aimed to determine the antimicrobial susceptibility profile of pathogenic Escherichia coli strains isolated from fecal samples of calves and buffalo calves (2008-2013), in Minas Gerais, Brazil, as well as the frequency of O157 gene and strains carrying extended-spectrum beta-lactamases (ESBL) and mobile colistin resistance (mcr) genes. E. coli strains (n=518) were tested for susceptibility against ten antimicrobials. Tetracycline was the antimicrobial with the highest resistance rate (382/518), foll...
Source: Comparative immunology, microbiology and infectious diseases. - March 5, 2024 Category: Allergy & Immunology Authors: Dirc éia Aparecida da Costa Custódio Carine Rodrigues Pereira Maysa Serpa Gon çalves Anna Cec ília Trolesi Reis Borges Costa Pedro Felipe Rodrigues de Oliveira Bruna Henrique Pinto da Silva Giovanna Botelho Carneiro Fernanda Morcatti Coura Andrey Pere Source Type: research
Introduction of a penicillin allergy de-labelling program with direct oral challenge and its effects on utilization of beta-lactam antimicrobials: a multicenter retrospective parallel cohort study
Self-reported penicillin allergy labels are common and often inaccurate after assessment. These labels can lead to reduced use of first-line beta-lactam antibiotics and worse outcomes. We measured the impact o... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - March 5, 2024 Category: Allergy & Immunology Authors: Adhora Mir, Derek Lanoue, Veronica Zanichelli, Carl van Walraven, Timothy Olynych, Caroline Nott and Derek MacFadden Tags: Research Source Type: research
Pancytopenia following adjuvant therapy with interferon gamma (IFN- γ) in a patient with disseminated nocardiosis
We report a case of pancytopenia following treatment with recombinant interferon gamma (IFN- γ) in a patient with disseminated nocardiosis. A 78-year-old woman presented with non-specific symptoms of general weakness, cough, fever, right-hand paresis, unsteady gait, and vision deterioration. Her medical record revealed multiple allergic reactions, notably to salicylates (including aspirin) , histamines, penicillin, ciprofloxacin, erythromycin, bisoprolol, and iodide. She reported having Henoch–Schönlein purpura, asthma, and arterial hypertension. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - March 5, 2024 Category: Infectious Diseases Authors: Thomas Derungs, Denis Poddubnyy, Thomas Schneider Tags: Case Report Source Type: research
